What follows Lupron and Zytiga?

[jfoesq]

Hi- I am 10+ years on Lupron and Zytiga (aberaterone), which included 3 vacations during first 5 years.

Left hip was radiated (a 2nd time) last June when PSA started to rise (to low numbers) after scan showed my largest tumor, located in my left acetabulum, was “active”.

PSA returned to <.05 once again following the radiation.

But- it was measurable at .05 one month ago and now .06 today.

I assume the next step is another scan.

If the scan shows my tumor(s) are “active” again, what’s the next step?

Olaparib? Chemo? Possibly more radiation of tumor(s)? DOCETAXEL

Thank you for your responses

[Tall_Allen]

Possibly. It depends on your metastatic activity.Possibly Xofigo too.

[jfoesq in reply to Tall_Allen]

Thank you for your response. I didn't realize til just now that all my HealthUnlcked emails were going to SPAM and just found them.

[tango65]

The cancer is mCRPC having failed lupron and zytiga, The other anti androgens have cross resistant with zytiga. The preference is to have chemotherapy with docetaxel.

Other possibility is to have Lu 177 PSMA treatment (pluvicto) if you could get it without having chemo.

There are clinical trials:

clinicaltrials.gov/ct2/show...

[Seasid in reply to tango65]

Maybe Zytiga is still working. He could have PET scans to see what is really happening. I work milk Zytiga up to failure. Only my idea.

[jfoesq in reply to tango65]

Thank you. Late response by me because my emails were going to SPAM and I just found them

[Hidden]

.05 to .06 could be the variation in accuracy of the test.

[Ramp7]

Lupron / Zytiga, LuPSMA177, BAT, responding well.

[jfoesq in reply to Ramp7]

Happy for you. My response is late because I just found all of my Health emails were going to SPAM. Thx and Good luck

[gsun]

My largest tumour is in the same spot. I need a hip replacement but because of the cancer it's risky.

[jfoesq in reply to gsun]

That's tough Good luck with whatever you decide to do

[j-o-h-n]

For me it's Lupron and Nubeq/a (/ = no u)...

j-o-h-n <===<<< Senior management is about to spike my spikes....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 04/19/2023 10:18 PM DST

[jfoesq in reply to j-o-h-n]

Thx for your response

[Seasid]

Could you just add Olaparib to Zytiga? And see if it helps? That is only my idea. Check with your team.

Your PSA is still very low. I would be happy with it.

If you have still bone pain than do the psma PET scan and see if you have a visible bone met.

I believe Zytiga is still working. I would not be to concerned. Milk Zytiga up to failure.

[jfoesq in reply to Seasid]

Thx.

[jfoesq]

Thx for your response. It seems as though my MO thinks there are may be at least 3 other hormone deprivation drugs to try, along with the possibility of additional radiation depending upon what scans eventually show. For now, we are continuing with the Lupron and Aberaterone until next set of labs 3 months from now. It's too early for scnas right now as PSA is too low.

[Seasid in reply to jfoesq]

Keep safe.