Can I do Provenge with Zytiga?

[Peterd110]

Been on zytiga for a little over a year. PSA rose from undetectable to 2.26 on oct 14. On oct 24 I had an appt with dr and he said to come back today ( oct 31) to discuss next treatment option ( Provenge, xofigo, Xtandi or PROSTAR trial using Xtandi) He did recheck my PSA on the oct 24 appt

So , backing up a little .... when I got my results from the PSA text on October 14 that shot up from 0.99 to 2.26 I switched from prednisone to dexamethasone. The PSA after that , 10 days later was 1.84. So is this significant?? Do I ditch zytiga or give it a little more time with dexamethasone? Could I do Provenge with zytiga??? I want to do all I can to beat back this cancer, but at the same time I want to get as much use out of each treatment as I can before giving up on it.

[Tall_Allen]

I think Provenge has maximum benefit when used with radiation or chemo.

Look for signs of radiographic progression before ditching Zytiga.

Why didn't you mention docetaxel as your next therapy?

[NOCanceros in reply to Tall_Allen]

Hello Tall_Allen

I would like to know provenge what it does mean.Thanks

Happy Hallaween

[Tall_Allen in reply to NOCanceros]

I don't understand what you are asking.

[Peterd110 in reply to Tall_Allen]

He didn’t say not to, but it has more side effects than the others, so he favors saving it for later.

[Tall_Allen in reply to Peterd110]

It has the same degree of side effects as abiraterone when used early (although different in kind). The idea of "saving for later" has no basis in medical evidence.

[Peterd110 in reply to Tall_Allen]

Well I don’t mind it. I just don’t want to give up on zytiga too soon.

[tango65]

It can not be administered because Zytiga is given with steroids. Steroids have potent immune-suppressive and anti-inflammatory effects.

archive.constantcontact.com...

[podsart in reply to tango65]

So can the Zytiga be replaced with Xtandi which doesn’t use prednisone?

[nobaday in reply to tango65]

What a GREAT informative article tango65. Thanks!

[leo2634]

Been on Zytiga, Prednisone , Xgeva for 21 months PSA 0.1 from start of treatments. I was administered Provenge in late June never stopped Zytiga before, during, or after Provenge infusions. So far so good and still undetectable. I guess it's ultimately the medical professionals decision as to the outcome of treatment and the patient individual Cancer. Never give up never surrender. Leo

[abmicro]

WHen I did it I had to NOT take zytiga. Just got a bottle of it and did not use it.

[Lynsi13]

We were told no.

[DrWrite]

Most of what I learned about Provenge is that it's effectiveness is minimal--extending life 3 to 6 months. Is it worth the cost? Well, of course we can't put a dollar amount on our lives, but at some point we have to weigh the advantages against the disadvantages and, for me at least, it wasn't worth it.

[Mazdaguy]

I realize this thread is a few months old...but this recent study showed significant benefit when Provenge was added to Xtandi or Zytiga:

ASCO GU: Real World Study Finds Adding Immunotherapy Reduces Death by 45% in Advanced Prostate Cancer

San Francisco, CA (UroToday.com) -- Dendreon Pharmaceuticals, a commercial-stage biopharmaceutical company and pioneer in the development of immunotherapy, released results of a first-of-its-kind study examining survival outcomes in men with metastatic castrate-resistant prostate cancer (mCRPC) who were treated with PROVENGE® (sipuleucel-T) and oral agents in a real-world treatment setting.

According to a retrospective analysis of medical and pharmacy claims data from more than 6,000 Medicare Fee for Service beneficiaries, the addition of PROVENGE to either Zytiga® (abiraterone acetate) or Xtandi® (enzalutamide), at any point in a patient’s mCRPC treatment regimen, reduced the risk of death by 45% and extended median overall survival (OS) by 14.5 months.1 These findings were presented in a poster session at the 2020 ASCO Genitourinary (GU) Cancers Symposium in San Francisco (abstract #42, Poster Session A, 11:30 a.m. PST).

urotoday.com/conference-hig...

[Peterd110 in reply to Mazdaguy]

Thank you!