Decisions

[Peterd110]

Zytiga has run its course, apparently. Psa 2.26 now Doctor says we have choice of 1) Xtandi 2) Provenge 3) Xofigo or 4) PROSTAR trial with Xtandi plus CPI-1205. Bone Mets only

[Tall_Allen]

Do you have high EZH2 expression?

Provenge+Xofigo may be a good combination and may take less time than Xtandi.

[Peterd110 in reply to Tall_Allen]

So 10 days ago I had my psa tested and it was 2.26 so I changed prednisone to decadron. I just got psa results from yesterday’s appt and it was 1.84.

[Peterd110]

I don’t know. The doctor thinks more on the lines of “ treat and see if it works” instead of testing for traits.

[Hidden]

What about Docetaxel chemotherapy?

[Peterd110 in reply to Hidden]

He wants to save that for later

[tango65]

When an anti androgen fails the sequence with chemo (docetaxel or cabazitaxel) could be more effective than using another anti androgen.

ascopost.com/news/october-2...

ncbi.nlm.nih.gov/pubmed/302...

One option could be to study the possibility of a clinical trial with modified niclosamide which could resensitize the cancer to abiraterone or enzalutamide:

clinicaltrials.gov/ct2/resu...

[Peterd110 in reply to tango65]

Thank you for the info!

[tango65 in reply to Peterd110]

Best of luck on this journey, your fellow traveler,

Tan Go

[Fairwind]

The Xtandi is quick, easy painless...Try it and see if it works and then go from there.. If you have bone mets only, the R-223 might be a good next choice..Combining it with Provenge could be productive if you can get that done..

[rhbishop2]

If the bone mets are limited in number, what about SBRT if your insurance will cover it?

[Hidden]

He failed to offer you low-dose Xtandi and sodium ascorbate. The latter actually kills Pca, and the Xtandi makes it kill even more. It is a very gentle solution that could buy you a few years with very low side effects.

[rassusukumaran in reply to Hidden]

Please show us the evidence, if indeed this works,

[Hidden in reply to rassusukumaran]

If you have not done enough reading and research to know that Ascorbate (Vit C) via IV is in common use in many countries and many oncology practices, then I cannot help you. I am not paid to lie about this, but many are paid to lie that it does not work. It is commonly used in combination with traditional treatments, but those are cut by 75-90%. It makes them affordable and far less side effects for the same results - actually better outcomes as patients are less damaged. The truth is very bad for business! It will cost you very little to find out what the truth is by testing it yourself. My docs figured I would die 2 years ago (and I nearly did). The Xtandi/Vit C combo had my PSA down to almost nothing in 4 weeks and saved my life. That is my evidence. I am not going to stop now and die to give the final proof of what happens to the "control" in this experiment, but you can take my place and see what happens without it. Don't forget to let the Forum know the result.

[rassusukumaran in reply to Hidden]

David, Firstly I thank you for the response. Maybe you are right that I am not as well informed. Sorry if I did not explain myself clearly I have come across many reports about IV Vit C and also many reports disclaiming and rejecting it. As a layman we are confused and uncertain about many things we see on the internet. Now that you have a positive personal experience, with Vit C, it is a personal testimony and I definitely believe you and would be grateful to know more about your experience. I have to convince my Oncos and any documentation or published report would help in this respect. That is what I meant. I am sorry if I offended you. Was on Zytiga that has failed for last 5 months with psa doubling every month and bone mets. Am desperately looking to control PSA.

[Hidden in reply to rassusukumaran]

When I was on my back with the PSA doubling every 10 days or so, I started taking Xtandi and added ascorbate drip as well. Within a month, my PSA was down 96% and heading lower. Xtandi on its own may have got the PSA down as well, but not nearly as fast. Then I used just 1 Xtandi capsule a week the night before a weekly 25 grams of ascorbate, and that kept my PSA <0.1 (undetectable) for a long time. Now 2 years and counting. Obviously it is the Vit C and not the Xtandi that is doing the work, but the Xtandi triples the Vit C kill.

Vit C on its own is not a potent killer (about 5% each drip) and will not kill enough fast growing cancer to keep it under control with reasonable dosages. Adding some Xtandi makes all the difference to survival.

[larry_dammit in reply to rassusukumaran]

Stage 4 here since August of 16, 6 rounds of chemo taxotere and started Xtandi with lupron after the chemo. 34 months at 0.05. PSA

[nobaday]

I switched to Dexamethasone from prednisone. The research shows you can get extended use of Zytiga this way. Search dexamethasone on the site to get the info. Particularly in your case as PSA not skyrocketed yet.

I switched to give my body a change but with the hope of increasing time of Zytiga effectiveness. At 20 months now of Zytiga and PSA at 0.01/ undetectable.

[Survivor1965]

I failed zytiga and have now been on xtandi for 32 months. PSA undetectable. Good scans. Xtandi is crazy expensive but lifesaving (or extending)

[Peterd110 in reply to Survivor1965]

How long were you on zytiga? I have been since initial diagnosis August ‘18. Now I’m worrying myself sick because it didn’t last no longer than that.

[Survivor1965]

It lasted less than a year

[Peterd110 in reply to Survivor1965]

Thank you I hope I do well on Xtandi like you.

[SPEEDYX]

I would try xtandi next myself...easy transition and let's see if it works...prayerfully it does👍

[Sxrxrnr1]

Have an AR-V7 test. If positive, almost certainly Xtandi will fail. If negative you should have perhaps a 15 to 20 percent chance that Xtandi will work. Both are AR inhibitors from somewhat similar families,,,hence failing one may leave you exposed to failing others of the family.

Advice on niclosamide for reset is good, however is almost impossible to obtain. UC Davis is running a trial on it. The drug original use was/is an anti-tapeworm pharmaceutical.

Indomethicine is another purported reset medication that may have clinical significance. ‘Tis a gout pharmaceutical.

I was on it for 90 days after failing Xtandi, preparing myself for release of Nubeqa(Darolutimide). My AR-v7 test was negative. Nubeqa too is of AR inhibitor family.

[Lt036]

Have only been on Xtandi for three months along with Lupron shots after Lupron stopped working by itself. Xtandi is helping but side effects have been terrible. Feel terrible, tired all the time, vertigo something terrible. Other than that not bad. If you get on Xtandi I hope you have better luck. I guess it’s better than the alternative. Good luck and God bless