Rising PSA after Hormone & Chemo Update

[Ian54]

Choline PET CT show mCRPC to Pelvic Lymph nodes. Radiotherapy not seen as option due to number of nodes affected and danger of damage to bladder and bowel.

Entered into Clinical Trial - Olaparib and Abiraterone in mCRPC. This is a world wide 20 countries phase 3 trial, 720 participants 50/50 placebo double blind trial. Olaparib is used in ovarian and breast cancer to stop the cancer dividing and spreading.

All participants receive Abiraterone. Ian

[j-o-h-n]

Thank you for the info....

75 years ago today those brave men saved our freedom, now don't let it dwindle away from us.

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 06/06/2019 6:19 PM DST

[HopingForTheBest1]

I am also BRCA2+, based on genetic tests from Color and Foundation Medicine. Also have PTEN, ATR and TMPRSS2 alterations.

I was on Zytiga and Prednisone for just six months before it started to fail, as my PSA rose from 0.12 to 055 in 3 months. My initial PSA at diagnosis in June 2018 was 20. Was switched to Olaparib, and my PSA is now at <0.01 after 3 months. I did have Provenge treatment in March/April, which I have been told does not affect PSA. Also on ongoing Lupron and Xgeva (for bone strength).

Since you are on a double blind trial, I assume you don't know if you are actually getting Olaparib. Wish you luck.