Increased PSA with Taxotere

[Molman]

Hi all, I have had 2 sessions of 3 treatments with Taxotere, and my PSA has gone up in the past 2 weeks from 260 to 290 to 300. My oncologist Hope's that the next blood check will see a decrease. What is the likelihood? I was diagnosed in June 2015 with T4 and Gleason 9.

[Tall_Allen]

Stick with it. PSA goes up as cancer cells die.

[tallguy2 in reply to Tall_Allen]

Not always...my PSA decreased during chemo, but...and it's a big but...I also restarted Eligard (ADT) a month before starting chemo.

[Hidden]

Mine held steady for two sessions and then crept up until it was notably higher on the last reading. I finished my sixth session January 23rd and it doubled a month later and today that number doubled again. So, you are not alone and I know that is no comfort for you but I hold positive thoughts for good news for you. I was diagnosed 4/18, less than a year ago. Hoping to kick it back down with Xtandi and Cabazitaxel which I begin very soon as part of a trial.

[Molman in reply to Hidden]

Thanks, for your reply. I was on Xtandi for a few months only, before the efficacy were off. I hope that together with jetvana it will be more potent

[Metungboy]

It can be evidence of cancer cell death. Sometimes the PSA climbs a bit then declines.

If it does thats good.

If it doesn't it suggests that the Taxotere is not working on your particular cancer cells.

[whatsinaname in reply to Metungboy]

I think the odds that the Taxotere is not working is 90% +

[Molman in reply to Metungboy]

Thanks, Metungboy. I hope that this will be the case. I am also taking a supplement which seems to help stabilize my blood. It's called Protectival, and produced by Life Biotic, a small Israeli company. Perhaps worth a try?

[podsart in reply to Molman]

Protectival looks interesting

Looks like manufacturing and distribution located in Netherlands with R&D in Tel Aviv, with prices in Euros.

Do you live in US?

[Molman in reply to podsart]

I live in Belgium

[podsart in reply to Molman]

Makes sense ; I didn’t check shipping to USA cost

Thanks

[Chubby42]

My PSA went up after the first cycle then steadied /remaind the same after the 2nd before dropping for the remainder of the other cycles until it got too .01.

Good luck hope it starts to come down.

[whatsinaname]

My considered opinion is for you to go with Nalakrats' advice.

Take a PSMA PET-CT scan and check whether your mets have increased in size and qty. If they have, stop chemo immediately and start on Abiraterone as a prelude to starting on Lu-177, especially if you are found to be PSMA avid. Take this seriously. I am talking from personal experience.

[Molman in reply to whatsinaname]

Thanks, will take this to my oncologist

[whatsinaname in reply to Molman]

Most welcome, Molman. All the very best to you.

[Molman]

Thanks, very helpful. I will discuss this with my oncologist

[podsart]

Nalakrats

Have you studied protectival mentioned by Moleman?

[j-o-h-n]

Greetings Molman. Sorry I don't speak Belgiumese. You've come to the right place for info and camaraderie. Could you tell us your age please. Thank you.

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 03/21/2019 6:10 PM DST

[Hidden]

You are taking Lupron injections during chemo, right?

GD

[Molman]

No, not taking Lupron at this moment, but will ask my oncologist about it. Thanks for thus

[Molman]

Hi John, I am 70 years old

[Kevinski65]

I'm 7 years out, Xtandi , Lupron and Zyflamend for prostate. ( Zyflamend Whole body is being studied for PCa.) I was PSA 31, stage 4, M1, Gleason 9, 3 bone mets, 5 months doubling time. Currently I'm PSA .02 , mets dormant or resolved...2 lymph nodes down to normal. Nothing doing on the PET, bone scan, or cat scan. I drink pom and green tea. I'm not giving medical advice but the doctors are pleased...I battle depression and fatigue. For pain I took a lot of aspirin but that screwed up my sinuses. I now take Aleve. I'd like to find a doctor to give me celebrex and metformin, so far nothing doing. If you ask u don't get with a lot of physicians. Good luck, pray , spoil the grandkids...oh yeah I'm 66 now.

[Molman in reply to Kevinski65]

Thanks Kevin. That sounds great. Continue the good work. I am 70 but no grandchildren yet. Will I see them? I hope so, I have a lot of bone tumors. Oh, I love green tea. I drink it every day. I go to Japan twice a year, to go shopping and see friends and family of my wife.