My husband is going to have ADT + Zytiga +radiation (prostate +lymph nodes pelvis + metastasis) in an aggressive approach to oligometastatic cancer (T3b, N1 M1, Gleason 9). He is fit but has atheroscleroses and will need stents.
Now for ADT I thought Degarelix would be the best choice regarding CVD.
They propose Zoladex + Casodex instead.
And adding Zytiga could be even more dangerous for CVD, so I am not sure we should begin with it, since he is getting "curative" radiation.
No - but there is no question that Xofigo is a better first step. There is actual data proving it works whereas met-directed therapy is anyone's guess.
Did you see the links I posted in one of your other posts? The PRONOUNCE study is still in progress, I think?? we wish we had stayed with an antagonist that seems to carry less of a burden.
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Can you really end all ADT?
Zytiga and ADT 
Back to ADT
Importance of ADT
ADT + Docetaxel
