Wondering if anyone has strong perspective on the benefits of 18 vs 24 months of ADT + Zytiga after locally advanced PCa? My original diagnosis at 53yo was Gleason 4+3, and post RALP surgery T2CN0M0 with 15 clear lymph nodes biopsied. However, persistent PSA and Axumin scan identified 2 avid lymph nodes not identified during surgery. EBRT radiation and ADT+Zytiga brought the PSA to <0.05 right away.
I'm soon approaching the 18 month mark (well, in 4 months still) and had been counting on that being the end. Tired of the fatigue and loss of energy and fitness. However, I've often seen people recommending 24 months. Wondering if the different duration is due to a) different diagnosis or b) different views on the optimal duration of ADT+Zytiga. I haven't been able to find any studies as a guide.