Phase 2 Trial of Irofulven to Treat M... - Advanced Prostate...

Advanced Prostate Cancer

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Phase 2 Trial of Irofulven to Treat Metastatic Castration-Resistant Prostate Cancer Opens in Denmark

JLS1
JLS1

prostatecancernewstoday.com...

Is anyone familiar with irofluven, which comes from jack o' lanern mushrooms?

This news today sparked my curiosity, so I did a couple quick searches on irofluven and discovered it isn't new, and was even fast tracked over 15 years ago:

Lots of info, so I'm hoping someone here who can decipher all this medical terminology may find irofuven to be very promising:

duckduckgo.com/?q=%2Biroful...

oncologyventure.com/pipelin...

"Irofulven has been evaluated in 19 clinical trials, predominantly in refractory prostate and ovarian cancer patients and all conducted without DRP-guided patient selection. Results were positive, including a 10% response rate in patients with prostate cancer previously treated with docetaxel and 13% in ovarian cancer patients relapsing between 6 and 12 months after standard treatment with carboplatin and paclitaxel, but were not deemed sufficient for regulatory approval by the previous owner of the drug.

*****The ongoing and planned studies using the Irofulven DRP are expected to significantly improve response rates seen in prior studies.*****"

2 Replies

There is a previous phase 2 trial:

ncbi.nlm.nih.gov/pubmed/156...

JLS1
JLS1 in reply to tango65

A belated Thank You!

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