Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

[jrodrig]

Hello,

I am a participant in the clinical trial NCT04221542, in the Vall d'Hebron Hospital in Barcelona.

Next week I begin the images exploration (TC, RM, Gammagrafia).

I will recieve the first shot of cytokines soon.

It is a very promising new drug AMG 509, but is the first phase of the essay, they are are going to test the security and I will be in observation consantly.

I will inform you how my trial is going.

[Maxone73]

hola, muchas gracias and keep us posted please. You can find others in that trial here. There were one or two guys.

[jrodrig in reply to Maxone73]

Thank you Maxone73. It would be great to interchange experiencies.

[Maxone73 in reply to jrodrig]

healthunlocked.com/advanced...

[street-air]

an earlier study showed some good results in terms of psa reduction

but watch out for cytokine release syndrome

annalsofoncology.org/articl...

[traxcavator in reply to street-air]

There is a significant chance that cytokine release syndrome correlates to immune response. Hopefully they're keeping track of this. As someone famous, whose name I forget, said: "Fever hates cancer."

John

[jrodrig in reply to traxcavator]

My oncologists told me thar probably I will the symptoms of a mild flu. I trust all the team of health workers and rechearches who will monitor me.

If this treatment works and my health improves I will be very proud of helping with my grain of sand medecine and sciencie.

[Voodoo33993]

I wish you all the best & yes, please keep us posted.

[j-o-h-n]

Con Dios....

Good Luck, Good Health and Good Humor.

j-o-h-n

[Steel67]

suerte hermano!!

[garyjp9]

You can be proud just for participating in the trial, whether it works or not. It does seem promising.

[jrodrig]

Hello, again

My doctors are gathering all the necessary information to start the immunotherapy. Blood test, images, biopsy... and if everything is correct on August 7th I will receive the first injection of immunotherapy.

For those of you who are curious about what the clinical trial is all about, I found a link with a drawing that shows very clearly what this immunotherapy is all about.

x.com/FabioSchutz78/status/...

I am very proud to be a pioneer in this treatment, only 90 men worldwide have received it so far.

[Maxone73 in reply to jrodrig]

I say suerte! And buona fortuna in italian! Keep us posted please!

[jrodrig]

I took my first infusion last wednesday. By the moment any secondary effect. Every wednesday I will have an infusion. Completetly monitored. I will publish first results when available.

[Tyson53]

I too was enrolled in the Amgen 509 trial. This took place in Pittsburgh. Started Jan ‘22. The first four infusions required a two day hospital stay for observation. I was given the lowest dose (0.1). Fever and aches right after first infusion but nothing bad and symptoms quickly disappeared. After one year in the trial, I developed a form of vasculitis (giant cell arteritis). The pain from this in my head and jaw was excruciating. Fortunately the Dr figured it out pretty fast and I was successfully treated with steroids. They were suspicious that the Amgen either caused or contributed to this problem so I was removed from the trial in March ‘23. The good news is that it appears to still be working 1 1/2 years after I was removed. Had scans and bloodwork last week. Scans looked good and PSA is still undetectable. Only treatment I’m getting is a Lupron shot (for testosterone reduction). During the trial, I was treated so well that I didn’t mind getting an infusion every week. Great staff at the Univ of Pittsburgh Medical Center. Faith has become a huge part of my life since I started this journey. Good luck!!!

[jrodrig in reply to Tyson53]

Hello , Tyson53.Are you still on undetectable PSA?

[Tyson53 in reply to jrodrig]

yes