After my husband's PSA did not respond to zytiga, after rising post docetaxel while on Lupron and Casodex, he was switched to Enzalutamide. His PSA went from 6 to 1.0 ( August to September 12) in a month, now a month later( September 12-October 28) it's already back up to 1.6. Is he really already resistant?
Enzalutamide Resistant already? - Advanced Prostate...
I would suggest that I have seen many cases including mine where the psa will go up a little and than down again, especially with a .6 rise I would give it a while. It is important that we get the most out of the limited therapies that we have, I say stay the course. I am not a Dr. just long time patient who has read many post and been through all therapies
Need to know more. I'm not a doctor. I have stage 4 prostate cancer, M1, 5 month doubling time , Gleason 9, PSA 31 at diagnosis. Currently I've been on Lupron close to 7 years, 2.5 on Lupron alone. Currently I've been 3.9 years on Xtandi and Lupron. PSA has been .02 for 3.5 years. So, how old is he? Does he smoke? How long has he been diagnosed? Does he still work? Did they keep him on Lupron while they tried Zytiga then Xtandi. Does he take supplement? PSA at diagnosis? Things like that would be helpful.
As already mentioned by Tall_Allen if he is resistant to Zytiga he will be more likely also be resistant, or develop resistance more quickly to Xtandi. The best way we currently have to monitor and confirm resistance is with a genetic blood test call the AR-V7 test.
This test should be paid for by Medicare after December 10, 2018.
There might be a way to reverse resistance to Xtandi. This is totally "off label," unproven and out side of the envelop.