Well, first of all the sign in should be EZGoin', EZGoi, because my husband is the easiest going person in the whole world. Long story short, diagnosed 27 years ago (at the age of 52) PSA 53, Gleason 7. RP surgery, followed 2 years later by 36 treatments Radiation, Shortly after began Casadex, Lupron for many years. 4 years ago spread to spine, 4 mets ... 10 radiation treatments on spine, and on Zytiga/Prednisone since 3/15 .... never had ANY side effects from any treatment ... Lucky, I know. PSA started climbing over the last few months, so when at 11 MO put him on Xtandi. This has been devastating with every bone and muscle hurting so bad. Had to come home early from vacation he was so uncomfortable (that together with his need for a knee replacement in the next couple of month.) I think the Xtandi also made the knee worse. MO took him off the Xtandi (4 pills) for two weeks and said go to 3 pills after two weeks. It has been 11 days, very little improvement. Thinking of having him stay off for at least 3 weeks or at least until no side effects before restarting. For anyone who is taking Xtandi, would love your input regarding side effects, dosage, any and all info. After 11 days off he feels a little better today, but only a little and still very difficult and has absolutely no energy at all. HOW ABOUT ANY OF YOU GUYS?