Advanced Prostate Cancer
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Tlow up from my last posting

I saw my oncologist yesterday and my next standard of care options.

Cabazitaxel (Jevatna), Enzalutamide (Xtnadi), Radium223

Clinical trial

Olaparib, Olaparib+Cendirinib

Enzalutamide+Atezolizumab

If you gents read my last posting, you'll know where I left off. Also can anyone give me any personal experience on these other options.

Thank you, Ralph

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I guess the good news is you have a lot of options, and the bad news is you have a lot of options. What are your thoughts about each after talking to your MO? One of the nice things about the Olaparib ± Cediranib is you get a tumor biopsy with it that might yield some useful treatment info. In the Enzalutamide ± Atezolizumab you will at least get Xtandi and you might get immunotherapy with it. You said you had a hard time with docetaxel although it was effective - are the side effects you had expected to be better or worse with Jevtana? An advantage of Xofigo is it might help with the pain.

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Thanks for your reply. You seem to be exceptionally knowledgeable on any and all treatment options. Right now I will be starting on Monday, 15 days of radiation (might extend longer) This is along with my daily Zytiga, Prednisone. If this doesn't work out. The other options are available to me. I'm also getting a lot of feedback on this site to try alternative natural treatments. But that starts to really confuse and scares me too. Do I start trying these other over the counter (supplements, powders, organics) while going through the medical options? Or just stick with my mo"s recommendations. Or do both at the same time, if it's safe to do so. I definitely want to avoid another round of infusions. I would appreciate your feedback.

Thanks, Ralph

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I'm not sure what kind of radiation you will be getting - 15 days is not what's typically given for anything. Do not take any supplements while you are receiving radiation - it may block what the radiation is trying to accomplish. From my POV, supplements are drugs, just as any FDA-approved medication is, and the patient is taking a risk in taking any without efficacy and safety testing, or knowing what is really in the bottle.

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They have just about put the Kitchen Sink in front of you---I see many options--and there are about another dozen PARP's in the works[Between the Lab and Phase 1 trials]. MY MO, Head of Pca Research at a Center of Excellence---when with him last week---said what is working its way to the front, in targeted drug therapy are certain combinations of a PARP, with a Checkpoint Inhibitor---and of course there is the work at J. Hopkins on BAT. You should be curious, as your MO should be as to any Gene Mutations, you may have, that can better direct all the options you have.

Nalakrats

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Thank you for this info. I just don't understand any of them. I wish I can be directed to a program that will work. Instead of trying everything under the sun that aren't as yet working for me.

Ralph

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Ralphie every one is different. Have you been Gene mapped--knowing any mutations you may have allows for best treatment selections--also I understand from Tall_Allen---here--that there is a newer AR-V7 blood test. This also determines the efficacy of Zytiga and Xtandi---and can itself call for Chemo, to not only kill Pca cells in the body but to also reverse the action of the AR-V7 Gene Splice variant, to resensitize the reuse of the earlier drugs. Sorry if this is all confusing. We here do not have Magic Bullets---just educated suggestions--and we are not Doctors. Make sure you have a Great MO, who specializes in Pca.

Nalakrats

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I hope I have a great MO. If you go into my past bio and posts you'll know what my treatments have been.

Thanks for your reply,

Ralph

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