Hello I'm a newbie.. Here's my story. My father was diagnosed with prostate cancer in 1994, very little treatment available at that time. We started out with 38 treatments of radiation, opted out of removing the prostate since Dr. said, "cancer was detected in lymph nodes". Started taking Lupron months later. PSA was down 0.002 for years. Moving along the timeline, PSA started rising and then came Casodex, few years later Lupron was added every three months. 2012 was introduced to Zytiga with Lupron every three months. My father has maintained a very active lifestyle, (hunting, fishing, gardening and etc). PSA remained under 2 for years. Now the story begins.. we went in for a checkup in October, had his CT, Bone Scans, no changes. PSA was up to 3.5 and we were told that Xtandi was next option. Jan 9th, 2018 he had a knee replacement nothing to with cancer, Feb 2018 went in for his 3 month checkup and PSA had risen to 7 and started on Xtandi (4 pills daily), within week and a half had swelling in joints and left foot was swollen. Went to Dr, they done a ultrasound and found a blood clot behind left knee. ( surgery done on right knee) he was introduced to 150mg Enoxaparin injection daily and reduced his dosage to 2 pills a day. Currently he has no desire or energy. THIS IS THE WORST PAIN HE HAS BEEN IN!!! Told me last night that he has had enough..my father is a christian, always upbeat and through all of this he has very positive. His nickname is FANTASTIC!! That was his response that he gave others when they asked how he was doing.