First off, a huge 'Thank-you' to all who replied to my posting a few days ago. We met with a nurse practitioner and the regular MO on Monday to discuss 'what's next' for Mike. It's clear that something else needs to be done -- the Lupron and Casodex are no longer keeping his PSA at a reasonable level. A few months ago it was at 3 -- now at 21.48. His MRI scans from last Thursday were reviewed and there were no real surprises there: his femur (I believe the left side) is not in good shape and there appear to be some small spots in the spinal area that may be impinging on some nerves (hence the back pain), but the MO was extremely concerned with his right hip. There is 'something' approximately 2.5 cm in diameter - he couldn't say whether it was a solid mass or erosion of bone due to metastasis - but Dr. stated that this is definitely at risk for breakage. I asked about chemo and he said that was his first choice. However, with the possibility of breakage to bones and Mike's pain levels, he wants radiation to these areas to help knock back the cancer and reduce his daily discomfort which even the morphine can't seem to help. Additionally, he said that Taxotere can't be administered at the same time as any radiation. (I didn't know that - always learning something new). MO stated that chemo is more of 50/50 proposition as opposed to a 90 percent chance of success (cancer and pain) with the radiation. He is also going to start Mike on Zytiga and Prednisone. When I told Mike pre-visit that I thought he might be put on Zytiga and the cost of the drug, his response was 'OH, COME ON'! We do have fairly decent insurance and were told that 'there are ways around it.' What ways? We have BCBS/TX (weird, since we live in WI), and I'm curious to know about the out-of-pocket expense. Moreover, though, I'd really like to know what others may have experienced with this drug combo symptom-wise. You may have already figured this out, but my husband is a fairly private person (he doesn't mind my writing here and has said he appreciates the research), but he does not like to talk about his cancer. The oldest of eight siblings, he is one of FOUR dx with cancer in recent years - two with kidney, two prostate - and lost his younger brother to metastatic kidney cancer in 2014. While he doesn't say so, I believe he's convinced that the same fate awaits him sooner rather than later. And when someone is in pain, I can understand not being optimistic or enthusiastic. Any thoughts about these treatments? I think he really wants to fight the cancer, but the physical pain makes it difficult. Any input is appreciated.