Is it possible to have PSA rising during Chemo while ALP keeps dropping? And what could be the cause of it?
My father who's been dxed stage 4 with numerous bone mets back in July 2017. He started ADT early August and started Chemo Sep 25, just finished chemo #6(last one) on Jan15.
His intial PSA was 700 and ALP 578. Since the start of ADT, his ALP initially rose to close to 1000 than started dropping drastically. PSA has been quickly dropping too until Dec. It was 2.21 on Dec 8 and now 2.26 on Jan 23. While his recent scans showed improvments both on bone mets and lymph nodes, I am a bit discouraged by the slight rise on PSA. His ALP is still dropping steadily, from 77 in Dec to 61.6 now.
Should I be concerned with the slight PSA rise? Do these tests fluctruate some times? Or is he heading to CRPC?
Any input or personal experience is greatly appreciated.