Is this PSA drop good enough? from around 600 to 80 in 3 month on Zytiga for CRPC.

[Zhyravlik]

Father dx 2017, Gl 9, T4N1M1, PSA 944. ADT till summer 2020 when PSA got to 175 and scan showed SUPERSCAN. Then 4 rounds of Docetaxcel in aug- dec 2020. PSA droped from 202 to 42, then up again to 250. In 1 week it`s was already 305. So doctors decided to change therapy. But because of burrocracy more than 1 month he was whithout any treatment. Then Dec 2020 started Zytiga.

Is this drop good enough? In begining of Dec he was in pretty bad shape and on painkillers. But now he feels pretty good, started to excersice and in positive mood.

But his ALP is very high 336, T 0,090, CRP 1,5

[Hidden]

I'd say that's an excellent response and he could easily continue to improve. Zytiga has worked very well for me for over 2 years now.

The most important thing is that he is feeling better and has a positive mood. Wishing the best for him.

[Zhyravlik in reply to Hidden]

Yes, thank you mood is very important, because few monthes before i thought he would give up. And that is why he didn`t make any PSA testing. And doctors just asked after 3rd month.

[LearnAll]

You need to sing the following song to your Dad....in melodious voice..

"Its falling..its falling..Its falling like a rock. .And Best is yet to come. "

[AlanMeyer]

Hello Zhyravlik,

I suspect that a durable, long lasting response to Zytiga is only likely to occur if the PSA goes well below the level of the last reading of PSA = 80. Still, it is clear that your father has gotten significant benefit from the drug. Whatever remission he achieves, I hope that he is able to enjoy it. His exercise and positive mood are good.

I wish him the best of luck.

Alan

[Zhyravlik in reply to AlanMeyer]

thank you. I was hoping to see something near 40, but maybe we eill se slow but steady decline.

Katya

[Tall_Allen]

Looks good to me.

[j-o-h-n]

Nice drop..... keep up the good work....How old is Dad....

SORRY, I JUST CHECKED AND HE'S 71 YEARS OLD...

Give him my regards.............

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 03/22/2021 7:15 PM DST

[Zhyravlik in reply to j-o-h-n]

he turned 75 . 71 was when at dx

[j-o-h-n]

Thank you, I stand corrected....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 03/23/2021 7:09 AM DST

[j-o-h-n]

Kerplunk!!!....thanks....

That's exactly what they told me when I was a stand up comic.....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 03/23/2021 9:48 PM DST