Foods/Supplements-Vitamins: Conjugated Linoleic Acid (2)

[pjoshea13]

Conjugated Linoleic Acid [CLA] is actually a large group of isomers, but the c9,t11 & t10,c12 are the most studied, owing to greater presence.

By the time that I was using CLA over ten years ago, interest seemed already to be fading on the PCa sites I visited. Tonalin was the hyped product - from safflower oil. More promising supplements came along & I dropped CLA.

Only 13 PubMed hits for PCa-CLA in 15 years, and most are almost not worth mentioning, IMO. Very little U.S. research.

Most recent first:

[1] (2015 - Turkey)

"In vitro synergistic efficacy of conjugated linoleic acid, oleic acid, safflower oil and taxol cytotoxicity on PC3 cells."

"Cytotoxic synergy between Tax, OLA and CLA shows enhanced cytotoxicity on PC3 which might be used in the therapy of prostate cancer."

[2] (2013 - U.K.)

"Conjugated linoleic acid reduced cell proliferation and viability in all prostate cancer cell lines"

[3] (2011 - Argentina - Review)

[4] (2010 - Canada)

"Our results suggest that downregulation of FAS by 10,12 CLA, but not by the 9,11 isomer, as well as inhibition of FAS enzyme activity by both isomers, may contribute to growth inhibition of cancer cells but only at relatively high concentrations."

[5] (2008 - U.S. - Button Mushrooms contain CLA)

[6] (2007 - U.S. - Review)

[7] (2006 - Korea)

"trans-10,cis-12 conjugated linoleic acid inhibits the G1-S cell cycle progression in DU145 human prostate carcinoma cells."

[8] (2006 - U.K.)

"Induction of apoptosis and inhibition of NF-kappaB activation in human prostate cancer cells by the cis-9, trans-11 but not the trans-10, cis-12 isomer of conjugated linoleic acid."

[9] (2005 - France)

"Conjugated linoleic acid isomers and their conjugated derivatives inhibit growth of human cancer cell lines."

"Intensity of response of each tumor cell line to fatty acids. The intensities of response of the tumor cell lines to FA were different (Tables I to IV). Indeed, the lung (A-549), colon (DLD-1) and breast (T47D and MCF7) tumor cell lines were relatively sensitive, whereas the prostatic (PC3) and melanoma (M4Beu) tumor cell lines were more resistant to FA treatment."

[10] (2004 - U.K.)

"Conjugated linoleic acid inhibits proliferation and modulates protein kinase C isoforms in human prostate cancer cells."

[11] (2003 - Canada)

"Conjugated linoleic acid inhibits mutagenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the prostate of Big Blue rats."

[12] (2003 - U.S.)

"Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors."

"The results of this study indicate that neither an isoflavone-rich soy protein isolate (SPI), nor CLA inhibit the in vivo growth and development of prostate tumor cells when administered in the diet either singly or in combination. Moreover, at the highest concentrations SPI and CLA (i.e., 20% SPI, 1% CLA), there was a statistically significant increase in tumors volume over controls. Administration of SPI at 10% in the diet also enhanced tumor growth, whereas at 5%, SPI exerted no measurable effect. CLA administration alone had no observable effects on AT-1 tumor growth."

[13] (2002 - U.S.)

"The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells."

"The t10,c12-CLA isomer exhibited the greatest potency against colorectal cancer proliferation, and the c9,t11 and t10,c12 isomers were moderately effective against prostate cancer."

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/251...

[2] ncbi.nlm.nih.gov/pubmed/241...

[3] ncbi.nlm.nih.gov/pubmed/217...

[4] ncbi.nlm.nih.gov/pubmed/200...

[5] ncbi.nlm.nih.gov/pubmed/190...

[6] ncbi.nlm.nih.gov/pubmed/180...

[7] ncbi.nlm.nih.gov/pubmed/170...

[8] ncbi.nlm.nih.gov/pubmed/164...

[9] ncbi.nlm.nih.gov/pubmed/163...

[10] ncbi.nlm.nih.gov/pubmed/154...

[11] ncbi.nlm.nih.gov/pubmed/126...

[12] ncbi.nlm.nih.gov/pubmed/125...

[13] ncbi.nlm.nih.gov/pubmed/118...

[Hidden]

Thanks, Patrick. Did ya hear? Neanderthals didn't really bonk their women over the head, and drag them around. All this time, and it was just discovered, it was a cartoon. How about that?!?

Joe

[j-o-h-n in reply to Hidden]

LOL and all this time I was bonking my wife over the head for nuttin?

j-o-h-n Sunday 10/29/2017 4:36 PM EST

[pjoshea13]

Nala,

(CLA is a fat, of course.) Perhaps they will add it back to no-fat yogurt? LOL

-Patrick

[pjoshea13]

Nala,

I put that comment in () for those who might not realise that CLA is a fatty acid.

Linoleic acid [LA] is interesting, in that those who know about the inflammatory effects of corn oil, etc, think of it as the evil polyunsaturated omega-6. In fact, LA is an essential fatty acid. The metabolic pathway of interest is LA-->GLA-->DGLA-->AA, where AA is arachidonic acid. (LA can also convert to CLA.)

From a PCa perspective, AA is a problem because cells have too much of it & too little of balancing omega-3 EPA/DHA. But high amounts of LA in the diet do not translate to unlimited AA. Again, lack of EPA/DHA is the issue.

In the epidemiological studies, high ALA (alpha-linolenic acid) is associated with aggressive PCa. But the men who fared worse were those with very little LA. That was me for a while. Before diagnosis I ate little fat, but I did have a tablespoon of Barleans flaxseed oil every day. Shot myself in the foot.

I have been wary of oleic acid for the following reason - in many cancers, the ratio of oleic:stearic acid goes up with aggressive disease. Why? & why make the probem worse by using olive oil in the diet?

The struture of the two fats are as close as they can be, & the body can readily convert one to the other. But how can cancers control that from a distance? & what is the advantage?

I had an expensive organic roast chicken recently that would have benefit from a chicken flavor injection. Since the bird flu hit locally two years ago, pastured birds are a thing of the past.

-Patrick

[Neal-Snyder in reply to pjoshea13]

Hi Patrick,

I'll have to look back in your posts, as I think you've discussed olive oil. Apparently, I didn't digest it properly. My wife has been cooking with olive oil, being careful not to overheat it. So what we thought was good all this time is bad, huh? How sad. I did learn from you that coconut oil is bad, after I fell in love with it.

Thank you,

Neal

[pjoshea13 in reply to Neal-Snyder]

Neal,

Olive oil is a good choice when there is no cancer. & maybe even when there is? But why does cancer want oleic acid to go up & stearic acid to go down? This happens regardless of intake.

People worry about fat intake, but the body makes fat:

"Excess carbohydrates in the body are converted to palmitic acid. Palmitic acid is the first fatty acid produced during fatty acid synthesis and is the precursor to longer fatty acids. As a consequence, palmitic acid is a major body component of animals. In humans, one analysis found it to make up 21–30% (molar) of human depot fat ..." [1]

Palmitic acid is 16 carbons (saturated). It's a small step to stearic acid - 18 carbons (saturated) - & then to oleic acid 18 carbons (monounsaturated midway - it's an omega-9). From either, other & longer carbon-chain fatty acids can be built. The body makes what it needs, but cancer interferes with that.

I like to avoid excess carbohydrates, so that limits production. Meanwhile, excess dietary fats are used for fuel.

I limit olive oil intake & opt for butter instead. Is that smart? I don't know.

But I do believe that the Med diet (40% fat) can improve survival odds - & Dr. Myers seems to have done well on it.

-Patrick

[1] en.wikipedia.org/wiki/Palmi...

[Neal-Snyder]

Patrick,

Thank you very much for your thoughtful, informative reply.

Butter? Really? You don't avoid dairy?

[pjoshea13 in reply to Neal-Snyder]

Neal,

I don't avoid the fat, but I do avoid the rest, with its IFG-I & calcium.

-Patrick

[Neal-Snyder]

Aha! Thanks, Patrick. Fat is not my issue either. I've lost weight that I really didn't need to lose during the time I've been trying to eat an anti-PCa diet. My wife wants me to fatten up, because I'm too skinny, but I'm having a hard time doing that. I did start eating pork again, because we were in Luang Prabang, Laos, & the pork dishes she ordered were delicious. (My seafood dishes were not; we were far inland.) Same for our local Vietnamese restaurant, back home. I'm still staying away from the carbs that might let me gain weight, but at too much risk.

Neal