Do not take Hesperetin with Taxanes!

[pjoshea13]

New study from Estonia.

"Cytotoxicity of different flavonoids and their effects on the efficacy of docetaxel and cabazitaxel were studied in the human metastatic prostate cancer cell line PPC-1"

"Simultaneous treatment of cells with taxanes and flavonoids baicalein, chrysin, luteolin, fisetin, quercetin, genistein or daidzein did not lead to any change in chemotherapy-induced cytotoxicity. However, simultaneous exposure of cells to hesperetin and taxanes resulted in 9.8- and 13.1-fold reduction in cytotoxicity of docetaxel and cabazitaxel, respectively."

***

Hesperetin in juice? [2]

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/303...

[2] ncbi.nlm.nih.gov/pubmed/111...

[kmack57]

Great, just finished my fourth dose of docetaxel and I have been taking quercetin the whole time. I have two more infusions so I guess I can stop the quercetin today! I am being treated at Hopkins and they did a review of my supplements and had no issue with any of them. I also take NOW Circubrain, Vitacost modified citrus pectin, Bioresponse DIM and Bronson K2 D3, see any issues with the rest of these Patrick?

[pjoshea13 in reply to kmack57]

Quercetin was OK! No harm done. Only Hesperetin was counterproductive.

The others look OK to me, but will be on the lookout for papers from Estonia. LOL

-Patrick

[kmack57 in reply to pjoshea13]

Thanks!

[kmack57 in reply to pjoshea13]

I read that article wrong! Jumped to a bad conclusion!

[cesanon in reply to pjoshea13]

"Quercetin was OK! No harm done. Only Hesperetin was counterproductive."

Patrick, if you think about it, we don't really know that. That is not what the study investigated.

The effective supplements are all powerful medications in their own right. Many of them are protective of all cells.

Most of them have unknown interactions with anti-cancer medications.

It would seem to me anyone undergoing any kind of potent anti- cancer treatment might be wise to temporarily suspend the supplement.

This would also be consistent with the James Watson paper I posted a while back.

Don't you think?

[pjoshea13 in reply to cesanon]

"Many of them are protective of all cells."

I have mentioned numerous times that we take these supplements at pro-oxidant doses to induce ROS in cancer cells. Nothing protective about it at all. Pointless to use low doses.

I responded to the Watson paper some time ago. I have no problem with it - only with your use of it.

[cesanon in reply to pjoshea13]

Patrick

1. Watson was only about anti-oxidents. I was attempting to be a bit broader.

2. Even with anti-oxidents, it is hard for most of us to know what dose is sufficient to induce ROS in cancer... and what is the actual dose we are getting from our chosen source.

You would know far better than me, but I would expect the studies to determine what these super critical does are few and far between... and even then available only for the more common supplements.

No?

[pjoshea13 in reply to cesanon]

IVC seems to be a relatively common CAM therapy for men with PCa (or I have met a disproportionate number of men online who have used it.) It is used because the doses are pro-oxidant & oral doses are generally not. It isn't cheap.

I have never used it (although I could get infusions locally), because all but one of the men eventually stopped the therapy before any benefit was seen, often because of financial considerations. The problem, as I saw it, was their expectation that IVC alone was sufficient to make a big difference.

Some say that we should shun antioxidant supplements, yet many claim to eat a "healthy" diet containing foods known for their antioxidants. Makes no sense at all if on a ROS-creating therapy.

I am not interested in a diet designed for healthy cells that might also benefit the cancer. I am not looking to convert anyone, but it should be clear from a number of my posts, that the polyphenols that kill PCa cells in the lab do so by inducing ROS - & you can't do that at physiological doses obtained from diet or low-dose supplements.

-Patrick

[Hidden]

Just a quick comment. When I did a six month chemo trial, absolutely zero supplementals My MO did not want anything to get in the way of cell apoptosis.

GD