Effects of Curcumin and Lactoferrin to Inhibit the Growth and Migration of Prostatic Cancer Cells

[85745]

Prostate cancer remains one of the main causes of death for men worldwide. Despite recent advances in cancer treatment, patients develop resistance after an initial period of optimal efficacy. Nowadays, it is accepted that natural compounds can result in health benefits with a preventive or adjuvant effect. The purpose of this study was to evaluate the effects of curcumin (CU), a bioactive compound in the spice turmeric, and lactoferrin (LF), a natural glycoprotein with immunomodulatory properties, on DU145 and PC3. Prostate cancer cells were cultured with and without LF (175 μM) and CU (2.5 μg/mL and 5 μg/mL), alone and in combination. Cell viability, migration ability, death receptors (DRs), and integrins (α3, β1) gene expression were evaluated, as well as human annexin V quantification and Akt phosphorylation. Differences among cells group, defined according to the treatment used, were assessed with ANOVA. The results showed that the effects of CU and LF are different between the two prostatic cell lines analyzed. In DU145, a reduction in cell proliferation and migration is reported both in the presence of single and combined treatments. In PC3 cells, there is a significant reduction in proliferation in the presence of CU alone, while the inhibition of migration is mainly related to the LF treatment and its combination with CU, compared to untreated cells. Moreover, the reduction in gene expression of integrins and Akt pathway activation were observed mostly in the presence of the CU and LF combination, including the upregulation of DR and annexin V levels, with greater significance for the DU145 cells. In conclusion, our results suggest that CU and LF may have a potentially beneficial effect, mainly when administered in combination, leading to a reduction in cancer cells’ aggressiveness

[mrscruffy]

Interesting, but wonder how it works in humans

[MateoBeach in reply to mrscruffy]

sciencedirect.com/topics/fo...

[Nfler in reply to mrscruffy]

Why don’t you try it n find out, it’s sold over the counter…😁

[mrscruffy in reply to Nfler]

I have gotten Lactoferrin in my whey protein for years. No positive changes in PSA

[Nfler in reply to mrscruffy]

Did you try it w the curcurmin, that’s when it seems to b most effective…

[SimMartin]

Interesting but as always is this effective in vivo and not just isolated cells

The other confusing issue is that lactoferrin used in supplements is typically sourced from genetically modified rice, it can also come from cow's milk. So is this contrary to those who suggest that dairy (casein in particular) is to be minimise for us the PCa ( though I slightly sceptical about how much impact).

Also doesn’t curcumin mess with PSA yeses and give Lower misleading readings ?

My brain gets to overload on what to do and not do as they can often be contradictory

[85745 in reply to SimMartin]

Curcumin has been used and shown to lower inflamation. In my opinion if CU lowers psa it's because it is a positive. likely due to CU therapeutic effects. I consider the source of both sides of the contradictions and try to make a evidence based decision. or just pass on it. Yes I read dairy is not good, but a lactoferrin taken from bovine ? I don't think it's the same effect. maybe research LF . All tho I did wonder about that myself with LF.

[Graham49]

Int. J. Environ. Res. Public Health 2022, 19(23), 16193; doi.org/10.3390/ijerph19231...

Received: 27 October 2022 / Revised: 25 November 2022 / Accepted: 1 December 2022 / Published: 3 December 2022

[gsun]

If CU messes with PSA numbers, should it be stopped before a blood test?

[MateoBeach]

I am convinced that curcumin is beneficial for multiple reasons. So I take it every day. Since I am mostly interested in changes in PSA rather than the exact value, so any small effect on measuring is not of consequence to me. I do not stop it for testing.

[MateoBeach]

Lactoferrin is a nutritional glycoprotein in the whey portion of milk. Interesting actions include anti bacterial antiviral and anti inflammatory. It is very resistant to digestive enzymes so can be absorbed to some degree. Any PCa effects notwithstanding it looks like a positive on balance. I take 30 grams of whey protein blended in water. So protein supplement with whey also provides lactoferrin. Does a body good.

[85745 in reply to MateoBeach]

Thank you for the feedback, good to hear. I just now started taking the Lactoferrin/ curcumin.

[garyjp9 in reply to MateoBeach]

Glad to hear that it works for you, but I see lots of cheers and jeers about whey protein among the brothers on this site.

[MateoBeach]

sciencedirect.com/topics/fo...

[FMOH_N]

Green tea and specially Matcha tea

[85745 in reply to FMOH_N]

Thanks , I take decafe green tea capsules, will try matcha. What a journey

[Redgold]

ncbi.nlm.nih.gov/pmc/articl...