A victim of success?

New study below [1].

Seems that when we manage to kill a lot of metastatic PCa cells, the process of cleaning up the mess causes a protein to be produced that actually stimulates growth in remaining cells.

{In normal circumstances, the body doesn't like a massive die-off of cells. There are mechanisms that support homeostasis. Perhaps no surprise that such a protein exists & would be triggered by a successful killing spree. IMO}

In another new study [2], the protein, CXCL5, is shown to have a a Protective Role in Coronary Artery Disease. Makes sense. But bad news in cancer.

A 2008 paper [3] reported that "CXCL5 promotes prostate cancer progression", so it should have been on a target list for almost 10 years.

CXCL5 is an "inflammatory mediator" [3].

"The challenge for the future is to understand how to treat these patients to avoid this pro-inflammatory and tumor promoting response, while still preserving the essential function of cell removal." [1]

Once again, a reminder that cancer is an inflammatory disease, & that control of inflammation may be key to survival.


[1] medicalxpress.com/news/2017...

[2] ncbi.nlm.nih.gov/pubmed/291...

[3] ncbi.nlm.nih.gov/pubmed/183...

17 Replies

  • Patrick,

    It never stops. I have hypertension, A-Fib, diabetes, kidney disease, and PCa. They are all trying to kill me. I am working at keeping them at bey. I believe, I can get other 5 or 10 years. With all the trails and tribulations. I am still enjoying life.

    I believe, I am blessed.


    PS: I have been fighting PCa for 19 years and counting.

  • Your secret is in humility believing that you are blessed, so you are blessed with gratitude .Sorry for your battles but thanks for the helpful words.

  • Lulu700,

    Thank you for your encouragement. I plan to die with the disease, not from it. In the meantime we have to enjoy the beauty of life.


  • That’s the spirit!

  • Rich,

    The way I would put it is that you're doing a an excellent job, you have the right attitude & are causing cancer-fighting endorphins by enjoying life, & you are fortunate in some ways. Congratulations & keep fighting & enjoying!


  • Rich,

    If only you could figure out why you have reached 19 years.

    When I was diagnosed, I had my eye on the 10-year survivors. Perhaps they knew the secret? When I hit 10 years myself, I knew that I couldn't adequately explain how I got there.

    But you are getting close to 20 years. You are a rare bird! Look out - a team from Johns Hopkins is on the way! Someone has to get to the bottom of this.

    Best, -Patrick

  • Patrick,

    When I was first diagnosed, the doctor said I am going to work hard to get you five years. I told my wife no, I am not going to accept that, and I began doing research. A few years later when I volunteered for the hospital PSA drive; I was taking lunch in the doctor's lounge and read an article that with my profile, said 10% make 10 years. I said to myself I am going to make 10 years. When I accomplished that, I put my sights on 20 years. Now, I want to achieve, 26 years. I am blessed, I am going to make it.

    I hope someday you will share that longevity with me.


  • Neal,

    Thank you for your support. I believe, I am blessed. I am enjoying life to the fullest. I hope, you too will have good outcomes.


  • That would be too bad if that protein exists---as I feel I have killed a lot of the bastards.

    Still keeping though, my C-Reactive Protein, at zero---WHO KNOWS!


  • Just a while ago I read about this damned truth about CXCL 5 on a link provided by another friend. When it is told by Patrick it really burns! GREAT is not the word! due to BigRich for his excellent attitude. Long live the King! BigRich! It is all in your self fulfilling prophesy.


  • I spoke to my oncologist about this inflammatory connection with cancer of which you speak. My C-Reactive Protein is very low, in the negligible range. Obviously, as a member of this forum, there is something that this test is not picking up. So, how does one know, as a fact, that this connection exists? Today, I also had my IGF-1 taken. Perhaps this may offer a clue.

  • As with Nalakrats, you might be taking enough polyphenols to counter inflammation.


  • In all humility, I don't think so. I asked my oncologist about this. His reply showed that he wasn't sure of what was going on. His answer was, well you'd probably be in worse shape had your CRP level been higher! I have been off any Pca medication, with the exception of Avodart, for two years this month (December).. During that period I received Provenge after which they radiated a small spot on a rib. I have forgotten the term, but this radiation following Provenge has been known to help kick-start the immune system. I am of the Nalakrats philosophy: everything including the kitchen sink. Except my "sink" has nowhere the number of dishes, pots and pans, etc., than his does (is that a scrambled metaphor?). As I mentioned, I had an IGF-1 test added to my lab work, yesterday. Maybe that will provide more information. Of course, my lab results could also come back with an elevated PSA and that would end further discussion.

  • Sisira,

    You know the power of faith and belief. I believe after 19 years, I am going to be a marathon man, 26 years. I hope, you too have a long life.


  • Hi pjoshea13

    I still have problem getting those terminology correctly. Any way in an environment of lots of dead cancer cells which then promote other cells to turn cancerous if not removed fast enough. There was and article using omega 3 with SPM.

    That is why I am using something close like omega 3 yo enhanced my treatment. After using this for the second time I can sense some relief. What I hope to achieve is to use this as an aid but letting my immune system deal with the waste disposal. Just my theory.

  • Roland,

    The problem seems to be the death rate - not clearance.

    We need to kill cancer less fast. A stealth approach. That way the tumor doesn't notice what is going on, & doesn't trigger the growth mechanism.


  • Hi Pjoshea13

    Thanks for the advise. I will remember this and try to incorporate this in my treatment.

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