Lupron/Eligard and Atrial Fibrillation Meds

My urologist is suggesting an eligard shot before I start radiation treatment. I've seen warnings about interactions with heart arythmia medications, in my case propafenone. Has anyone experienced serious interactions between eligard/lupron and these heart meds? My cancer isn't advanced. Maybe I should just get the radiation and forget the chemical castration fun prior to the radiation?

9 Replies

  • No, go for it ...

  • WSOPeddie---There are so many protocols, and combo's---that it is really up to your Doc. You could also get a second opinion. If you have a non-aggressive cancer, and a low PSA, he may be trying to wipe the cancer out in combo with the radiation.

    Myself after surgery--6o days post---My PSA was so high you would think that I did not have surgery. And it was very aggressive--4+5=9. I COULD NOT HAVE RADIATION--as all my Docs. determined that my cancer was out of the prostate bed and on the move. Anyway for your info at my Cancer Clinic--they use Lupron, and Casodex before radiation!!!!!

    So with radiation out we discussed all options--they were all drug options + what I could do with supplements; some in Clinical Phase Trial Testing. We almost went straight to Xtandi--which you kind of hold back on until much later on your prostate cancer travels. We discussed Eligard--and even though I am 72 and in excellent shape--weight lifting and body building--for 45 years, My Urologist said he had some good success in the past with a Vantas[Lupron] Implant. It gets implanted under the inner upper arm. A 3 Minute procedure. So we opted to see what would happen--as the Doc. figured we had time to experiment. We did the standard Casodex addition, and Proscar to prevent the formation of Dihydroxytestosterone, from Testosterone from the Adrenals, as the Implant would take care of the testes production. The DHT is Prostate Cancer food. By the way the implant is good for at least a year. Some of his patients kept the same implant in for 2 years before changing it out. Nice thing no injections--and I had no menopause flare-ups. A little feeling warm for a few minutes some nights.

    So when adding my supplements to the drugs--I went from a Pre-Op PSA of 20.2 to a Post-Op 60 day out PSA of 7.4. In 4 months I went with my multiple very active surveillance PSA's as such: [7.4->.75->.41->.11->.03->undetectable this week]. We discussed all options, yesterday, which included Eligard. And my Urologist, wants to stay the course for a long time. He wants me to continue my supplement program[He kind of knows what I am doing---but leaves it to me], continue my high protein diet program and my weight lifting program. He said we may take a vacation from the drugs in a year, or two--if I stay undetectable--to see if the Cancer awakens---and if it does we whack it again with the same protocol. If that fails we move to Xtandi. That is above what I am doing. Prayed thanks and glory to God for the Undetectable PSA this week. Was introduced to a patient who my Doc. wanted me to meet--a retired Cancer Biochemist from Bayer, who got very aggressive prostate cancer himself. He went 4 years with the same Vantas Lupron implants. Stopped all drugs 6 years ago--and just uses supplements. He has been 0.3 as to his PSA for those 6 years. Does a PSA every 6 months and lives a normal life. We met to compare supplemental programs, as he believes it is his supplements now keeping him in remission.

    So I tell you all this as we are dealing with over a dozen cancers, and each man has a different DNA and T cell activity, as well as different eating habits, and etc. So what works for me may work for you, or it may not. Who knows I might wind up on Eligard as an in-between step to Xtandi. Or as I pray there will be the next discovery which will provide us men with prostate cancer a very long life. Also remember, not all Docs. follow the same protocols. Who is to say what is best, for any one patient at anyone time on the journey, with the many different forms of the cancer, and many different make-ups of the physical nature of the patient!



  • Thanks for the quick replies guys. 5 of 12 cores positive: a 6 a few 7's and an 8, so Gleason 8 it is -- aggressive. I am leaning toward radiation but will be getting a 2nd opinion on whether surgery is possible after prior TURP surgery 10 years ago. I wish there were a way to test my reaction to lupron/eligard before getting a 6 month shot. I'll be asking the 2nd urologist his opinion on all of these options too. Anxious to get going on treatment. The CT and bone scans were negative but I've heard of disappointing findings after that. This is a nice active board.

  • Nalakrats ,

    What type of supplement program are you on?

  • Wayne it is extensive. It is divided into general health, bone health, cardiovascular system, work out, and NOW prostate cancer attack.

    I started supplementing in 1967--when you could buy Vitamin C and a somewhat Multivitamin. I assume you are looking for those things I designate for Prostate Cancer. Before giving the specific list, let me say that everything I do is to affect positive health--so all these things are good against cancer, by supporting general health.

    Below are the materials/supplements I am Using against my Ductal Cribriform:

    1] Pectasol-C--to tie up Galectin-3--which when expressed with cancer, aids and abets metastasizes, by angiogenesis. 15 grams a day, in divided 3 equal doses as done in the current clinical trials in Israel and the USA

    2] Vitamin D3, 5,000 IU's 2 times a day. Now in Clinical Trial. Trial at MD Anderson, currently injecting the Vitamin D3--I have to take it orally, Plus I sunbathe 4 times a week--morning Rays only from 10am-11am

    3] Glutathione/N-acetyl cysteine--NAC--is converted to Glutathione in the body, and I am also adding straight Glutathione. G-500 mgs 3 times a day. NAC-600 mg 2 times a day. The Glutathione is the mother of all antioxidants, that attach themselves to, or react with free radicals. Some consider cancer cells to be free radicals. Glutathione is or has been in Clinical Trial Tests.

    4] Vitamin K1-K2 super complex. K1 Kills prostate cancer cells that have metastasized--but not landed in bone, by Ocosis[type of cell death]. K2 transports Calcium to the bones which one needs to keep bone density when on ADT. I take twice a day[forgot the dose--but it is like 1,000 times RDU. You cannot take if on blood thinners.

    5] Pygeum--This is the bark extract of the Chinese Plum Tree. Used I Germany and France to halt cancer spread. They have had some success--so I added it--it does not hurt. Mostly used by Homeopaths.

    6] Sodium Selenite 500mgms twice a day. Was or still in Phase 2 Trial Testing. Acts as antioxidant, but plays another role unknown as of yet, as discussed with a research prostate cancer Urologist. It might have been MD Anderson that tested this or is still at it.

    7] Lycopene--was it Trial tests and had some minimal positive effects. About 15% of the patients showed a drop in PSA. I added this as again the extracts of tomato skins cannot hurt you. I take 30 mg twice a day

    8] Enzymes[nattokinase, serrapeptase and pancreatin.] besides other health benefits for keeping blood from clotting dissolving fibrin in the blood. The Natto and Serra, when in contact with prostate cancer cells starts dissolving the outer protective shell which is a fibrous type material---exposing the cancer cells to the body's own defensive T cells. It has been observed in Vivo[petri dishes] that the cancer cells when in contact or near the enzymes give up their outer protective layer and cell death occurs. I take 120,000SPU's of Serra in divided doses on an empty stomach and 6,000 FU units in divided doses.

    I do some other things--which causes controversy so what is above is 90 % of my arsenal against my cancer along with my Vantas[Lupron implant], Casodex and Proscar. So I am using the kitchen sink approach---all supplemental materials above have had scientific, or are in scientific phase testing. Even though failing Surgery, not a candidate for any type radiation, and not one that Chemo was considered, due to age[72], and the unknowns of Ductal Cribriform---the program above is what got me to undetectable PSA[Drugs and Supplements], in 4 months. My Urologist thinks I am a miracle--others here on the site--think I had a normal response to the drugs but are not informed as to Ductal Cribriform. As all the info we have on it can be typed on a 3x5 index card, because it is so rare. All of the drug companies threw up the hands on how to fight this--so my Doc. and I have our program--he does his part and I do my part. Any questions on where to get things, costs, or other questions hit me up. Glad to pontificate, you can also study the above, using the Internet. Going to sun myself, now, and thank God and continue to give him the Glory in getting me to where I am today.


  • I have Atrial Fibrillation since 2008 and I am taking Multaq which is for my arrhythmia and have been on Lupron for 3 years and I have not had any problems! And I also walk Friday,Saturday and Sunday 2-3 hours steady on the beach every week! I hope this will help you.

  • You better check with your doctor, for Bicalutmide may interact with your medication. In fact, discuss with your doctor all medication interactions.

    Good Luck, Rich

  • I have AFIB and metastatic PC; also have had a tissue valve replacement. I'm on metrororol, luprone and Xtandi. Things seem to be going ok other than typical fatigue from Xtandi. I was on propafonene before my cardiologist switched me to metrororol. Suggest you get a cardiologist consult before making a decision on whether there are any adverse drug interactions.

  • I think what is crucial in treatment selection is the determination whether the Ca is local or metastatic. If it's local, either surgery or rad will cure the Ca without any additional treatment. Once it has metastasis, it has become a chronic disease. And unfortunately, scan technology is unable to detect micro mPCa. So your doc is guided by your test results which may not be complete due to undetectable micro mPCa as the case may be. Local case is curable, metastatic is not no matter that you threw the kitchen sink at it.

    I say this from my own experience. After my rad treatment, my PSA went on a slow and steady rise. All scans before treatment and after my PSA had risen to 5.9 were negative. Finally, I underwent MRI with colorectal coil to hunt where the activity is. The result was a suspicious swollen lymph and it also showed no recurrence in my prostate. My prostate was basically fried. A biopsy was positive on the lymph.

    I have since underwent ADT 3-month Lupron. From the 7.8 PSA I started with upon ADT treatment, it dropped to 2.0. And in the next 4

    3-monthly checkups and treatments, my PSA was undetectable. My switch to an onc who is a specialist on prostate Ca was a turnaround. My onc will maintain my treatment since I appear to be in a class that responds well to the ADT with manageable side effects. And this is specific to the PCa type I have and the treatment chosen for me. I'm also hoping like the rest of us in this situation I hold it at bay, then, a treatment would come about that PCa no longer is factor to my life.

    I don't know of any data that supports whether concurrent ADT to primary treatment extends survival with desired quality of life. And if your case is local, it's an over treatment which may affect quality of life if you happen to be in a class to get serious side effects from it.

    And if your combined treatment is successful, would you end ADT. I believe data shows, if one has mPCa, it returns at some point after ending treatment. You would discover later than sooner that you have mPCa under a combined treatment. I don't know whether that's a plus or negative in a quest to beat down this disease.

    Our journey in the case of PCa is complex and difficult for the fact that PCa can be undetectable while circulating in our system. Is it local or not I think is the big Q.

    I wrote the above without any knowledge whether your heart med is a factor to ADT. If it's a major factor, I would discuss with my doc whether to look into additional treatment, such as ADT, if and when you have to cross that bridge. We're hoping you never would have to. Such as the nature of our beast.

    My best regards to you.

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