Advanced Prostate Cancer
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Foods/Supplements-Vitamins: Blueberries - Lowbush

Some years ago, my wife & I took a trip through "down east" Maine into Canada just as the wild blueberry crop was coming in. That was a treat. A significant portion of the crop is sold as frozen blueberries.

The lowbush blueberry (Vaccinium angustifolium) is high in anthocyanins - a type of flavonoid - & pterostilbene - a stilbenoid, related to resveratrol, but with much greater bioavailability [6].

[1] Life Extension sells a wild blueberry extract.

The following are all cell studies.

[2] (2005 - Canada)

Cells are held in place by an extracellular matrix. For PCa cells to become mobile, the matrix must be broken down by enzymes: the matrix metalloproteinase family (MMPs).

"three flavonoid-enriched fractions from lowbush blueberry (Vaccinium angustifolium) down-regulated MMP activity in DU145 human prostate cancer cells.

"findings indicate that blueberry flavonoids may use multiple mechanisms in down-regulating MMP activity"

[3] (2006 - U.S.)

This study looked at the effect of different fractions of proanthocyanins from wild & cultivated blueberries on DU145 & LNCaP PCa cells.

"Differences in cell growth inhibition of LNCaP and DU145 cell lines by blueberry fractions rich in proanthocyanidins indicate that blueberry proanthocyanidins have an effect primarily on androgen-dependant growth of prostate cancer cells."

[4] (2007 - Canada)

"The growth of various cancer cell lines, including those of ... prostate ... was strongly inhibited by ... low-bush blueberry, ... but not (or only slightly) by ... high-bush blueberry ..."

"No correlation was found between the anti-proliferative activity of berry juices and their antioxidant capacity"

[5] (2013 - U.S.

"Altogether, our results indicate MTA1 as a major contributor in prostate tumor malignant progression, and support the use of strategies targeting MTA1. Our strong pre-clinical data indicate {Pterostilbene} as a potent, selective and pharmacologically safe natural product that may be tested in advanced PCa."








1 Reply

Another amazing writing. Such inspiration, thank you..


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