Some years ago, my wife & I took a trip through "down east" Maine into Canada just as the wild blueberry crop was coming in. That was a treat. A significant portion of the crop is sold as frozen blueberries.
The lowbush blueberry (Vaccinium angustifolium) is high in anthocyanins - a type of flavonoid - & pterostilbene - a stilbenoid, related to resveratrol, but with much greater bioavailability [6].
[1] Life Extension sells a wild blueberry extract.
The following are all cell studies.
[2] (2005 - Canada)
Cells are held in place by an extracellular matrix. For PCa cells to become mobile, the matrix must be broken down by enzymes: the matrix metalloproteinase family (MMPs).
"three flavonoid-enriched fractions from lowbush blueberry (Vaccinium angustifolium) down-regulated MMP activity in DU145 human prostate cancer cells.
"findings indicate that blueberry flavonoids may use multiple mechanisms in down-regulating MMP activity"
[3] (2006 - U.S.)
This study looked at the effect of different fractions of proanthocyanins from wild & cultivated blueberries on DU145 & LNCaP PCa cells.
"Differences in cell growth inhibition of LNCaP and DU145 cell lines by blueberry fractions rich in proanthocyanidins indicate that blueberry proanthocyanidins have an effect primarily on androgen-dependant growth of prostate cancer cells."
[4] (2007 - Canada)
"The growth of various cancer cell lines, including those of ... prostate ... was strongly inhibited by ... low-bush blueberry, ... but not (or only slightly) by ... high-bush blueberry ..."
"No correlation was found between the anti-proliferative activity of berry juices and their antioxidant capacity"
[5] (2013 - U.S.
"Altogether, our results indicate MTA1 as a major contributor in prostate tumor malignant progression, and support the use of strategies targeting MTA1. Our strong pre-clinical data indicate {Pterostilbene} as a potent, selective and pharmacologically safe natural product that may be tested in advanced PCa."
-Patrick
[1] lifeextension.com/Vitamins-...
[2] ncbi.nlm.nih.gov/pubmed/161...
[3] ncbi.nlm.nih.gov/pubmed/163...
[4] ncbi.nlm.nih.gov/pubmed/174...
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