Dx 9/2010 with agressive PCa. Failed RP, hormone injections every 3 months. Mets in pubic rami. Current diagnosis 1mCRPCa. On Trelstar, Xgeva and Zytiga. Recent blood labs showed rising PSA. Next blood lab late July. If PSA continues to rise: New nuclear scans and an eye toward replacing my Zytiga therapy with Xtandi. As you can see from the following abstract, the differences are nominal. I've been on Zytiga for 13 months.
How Effective is Xtandi vs Zytiga?
The effectiveness and safety of Xtandi were demonstrated in a clinical trial that included 1,199 men who were given either Xtandi or placebo. Median overall survival among men who took Xtandi was 18.4 months compared with the placebo group at 13.6 months. Thus Xtandi extended survival by a median of 4.8 months.
Zytiga was evaluated in a clinical trial with nearly as many participants (1,195 patients) who received either Zytiga once daily plus prednisone twice daily or a placebo. Median overall survival for men who took Zytiga was 14.8 months compared with 10.9 months in the placebo group. This resulted in a median extended survival of 3.9 months.
My question for the group is, has anyone followed the same therapy sequence as me? What were your experiences? Has anyone advanced from either of these therapies to Doxetaxel (drip infusion chemotherapy) or radium-223 (Xofigo) therapy? If so, what have been your experiences? Lastly, has anyone skipped any of these therapies in favor of a canabis based therapy?