In a small trial, 5 of 28 men (18%) got a PSA response (dropped at least by half) from the combination even after Xtandi alone failed. Median survival among responders was 42 months (some still alive at follow-up) vs 19 months for non-responders. It is not clear how to choose those who will respond based on tumor biomarkers.
Xtandi+Keytruda may still work after ... - Advanced Prostate...
Advanced Prostate Cancer
Interesting TA, thanks 😊
Could I ask if this means if xtandi fails there are 19 months left...
Also do you know if pembro and xtandi together are being used in Europe in trials or as a treatment?
Thank you for your imput😊
It only means that in this group of 28 men, many of whom had already had abiraterone, chemo, and other therapies, 14 of the non-responders to the combo therapy lived longer than 19 months. It is not generalizable.
There are these trials of the combination in Europe for mCRPC:
Thank you Tall_allen appreciate that info😊
Also from the link Tall_Allen originally provided, it might be noted that the trial participants only got 4 rounds of Keytruda, and that due to the relatively small numbers involved there was a considerable 95% Confidence Interval range in the Overall Survival for individuals on either side of that Median value of around 19 months.
"For the 23 non-responders, median follow-up time was 36.5 months;
median PSA PFS time was 3.1 months (95%CI: 2.8 to 4.4 months);
median time to subsequent treatment was 5.2 months (95%CI: 3.8 to 8.5 months);
and overall survival was 18.6 months (95%CI: 13.4 to 26.4 months)."
When it comes to individuals, sometimes "The Median Isn't the Message".
(See also the Classic essay by Stephen J. Gould)
Hi in your opinions would keytruda and xtandi work with someone who has advance bone mets (super scan) and hemo below 8?
No I just saw your post and thought it could be an option. My friend has done the Lu 177, chemo, zytiga and now in Xtandi. Dr’s as you would say do not have anything yet they can think off from the tool box. Thanks
Not what you're looking for?
You may also like...
going on to Zytiga after Xatandi? I was on Xtandi for 4 months and it did not work from day 1 ....
ideas as I sense his 16 month run with Xtandi will be ending soon. His is PSA is fluttering.
i have been on this trial for about 5 months with few side affects up until a week age but now have...
was put on Zytiga and Xtandi together in a clinical trial which only reduced my PSA to 53 at the...
being taken off Xtandi though his PSA is low (3.7) they suspect his PC is not producing PSA. His...