I'm wondering if anyone else here has had any experience with treatment-resistant depression. I was put on anti-depressants at age 15 (I'm 27 now). I've been tried on different doses and combinations of SSRI's, atypical antidepressants, mood stabilizers, etc. Also undergone extensive therapy with multiple doctors over the last decade, and been hospitalized twice. Basically, it has reached the point where despite any of these interventions I am in and out of a severely depressive state (whether on or off of medications). I'm wondering if anyone else has been in this boat, and how they have dealt with it. I'm unwilling to try any more medications, due to the fact that they have done more harm than good, and I'm not willing to run the risk of becoming more anhedonic (I've had a harder and harder time getting back to a baseline with each medication they've tried, and have been told that it is most likely because of the SSRI's at such a young age, and their risk of permanent damage to the serotonin receptors that are having a hard enough time as is).