Hi, I need to have my spleen removed due to a rare benign condition. The problem is that I get Thrush at the drop of a hat and always when taking any antibiotic. I have been told that I need to take a low dose antibiotic every day and am concerned that I will have Thrush constantly. Fluconazole does not work , only canestan pessaries The doctors seem to think it is a minor problem but I am not happy about long term affects. Has anybody on long term antibiotics e.g for acne or indeed removal of spleen had constant thrush? GP says that eventually the normal flora of the vagina will sort itself out but I have seen no evidence of this when googling.