Can pcos cause sudden anxiety caused by excess oestrogens? 2 years ago I suddenly developed severe crippling anxiety and was put on antidepressants. I noticed that things were bad when estrogen was at its highest levels in my cycle. Was put on the pill which has helped immensely, but I still don't feel right sometimes. I have ocd which has worsened on the pill. And if I go through a stressful time, I feel more stressed than I would usually do. I am thinking of taking metformin to help balance things out as I am IR too. Heard it can help with balancing cortisol, insulin, and help with mood. I feel like the NHS has never really helped me pinpoint the cause of my sudden anxiety. I feel like the pill is just masking the problem. I wonder if the docs can test cortisol levels or progesterone, or would you need to be referred to an endocrinologist to get those tests. Any advice would be most welcome.