I've been taking prednisolone in varying doses between 80mg and 1mg for 28 years. At first I got Cushing's Syndrome and went from 8stone to 14 stone. Eventually I got back to my normal 10+ stone.
I am now on 2.5mg but need an increased dosage when I get a chest infection. For me they have been a life-saver.
I do wonder, though, if they cause me to be a bit depressed.