I'm just after some advice / experiences from people about intolerance to Methotrexate and what they were switched to (if it happened).
Initially I was prescribed Azathioprine back in March 2014 at 75mg daily, but only lasted a few weeks before I reached the point where constant nausea and vomiting meant I had to stop.
I was switched to Methotrexate at 15mg once weekly (tablet form) and all was fine with side effects for over 6 months before nausea gradually started again. After a couple of months debilitating nausea was lasting 3 days after the weekly tablets (and the Methotrexate effectiveness on my symptoms was also reducing). It was decided to switch to injection form again at 15mg once weekly (this is regarded as a slightly higher dose but was done to counter what looked like a flare). Again, all was fine for 6 months with regard to side effects (and my symptoms also calmed again). However, the same thing has happened again, in the last month horrendous nausea has returned again - slowly at first but now dreadful for days after each injection (also, the symptoms have started to flare again).
During all of this, my blood tests have not shown any issues which would require the methotrexate to be stopped for organ damage.
I will be speaking to my Rheumy Nurse in the next few days, but I really value this forum and the advice given, so what I was hoping for is some advice or experiences from people of any similar things that might have happened to others and what was the next steps for treatment etc. I realise that the methotrexate is doing a important job, but you really can't continue with the drug if you are completely unable to function for half the week.