I am in severe pain in my calf muscles when I have walked around 100 metres. I am told that. 2. Small arteries below the knee are somewhat blocked and an angioplasty or arterial bypass are not possible. I just have to exercise as much as possible including walking through the paiin barrier, which should improve matters after a few months, but it may nobody improve at all. I have had both a liver and kidney transplant as a result of amyloidosis.