Can T3 (tiromel) cancel the effect of ADHD meds?

[gavan104]

Good afternoon, everyone,

Please share your experience with concomitant use of T3/T4 medication and ADHD medication. I started Concerta in September last year, and a small dose worked beautifully. I started tiromel/euthyrox in November. The effect Concerta has on me has changed - instead of being calm and collected, I become almost drunk and unable to think straight. I am worried if I tell the truth to the neurologist, she will stop the prescription.

Tiromel is 2.5mg taken before bed. Concerta is 18mg, taken in the morning. Euthyrox alone does nothing to me, I am a poor converter.

I just wasted yet another day sitting around like a dummy, cannot nap and cannot do anything meaningful. It seems I cannot take Concerta anymore. Out of the two meds, I need tiromel more. Any info will be greatly appreciated, thank you very much for your inputs.

[Tina_Maria]

Just a thought: Are you taking the extended release formulation of concerta? This has a half life of 12h - so you would have half of that dose left after 12h (and half of that after another 12h, etc.). And in the morning you would dose again, so you top up and keep your medication at a certain level.

You take the T3 in the evening, however by that time you would still have some of the concerta left in your circulation. When you add T3, this would act as an energy provider, e.g., speeding up heart rate, metabolism etc., which is the opposite effect of the concerta, which is more sedative. So it is quite possible that some of the effects of the concerta would have been blunted (hence the unusual sensation).

Do you know a knowledgeable pharmacist? They are sometimes a bit more clued up about drug-drug interactions / pharmacology and could perhaps advise you. It could be that you need to increase your dose of concerta, but you obviously would need to discuss this with your prescriber.