Sub-clinical hypothyroidism - Trial agreed - Thyroid UK

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Sub-clinical hypothyroidism - Trial agreed

Flamborian profile image
6 Replies

Finally had initial appointment with GP on 27 Nov to discuss NHS and Private Thyroid Function Test results, which indicated Hashimoto’s and Sub-clinical Hypothyroidism (SCH). Just wanting to say a huge thank you for the support, advice and information given on here, which greatly helped navigate the issues with the GP.

All Thyroid hormone test results shown at end of this post. Previous posts/results here:

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

GP was a little dismissive/reluctant as TSH results were sub-clinical (“it’s complicated”). I confirmed I would not consider a statin until, at least, Thyroid issue was addressed (was being pushed hard by GP and Cardiologist to start) especially given reduced kidney function results. Said I was also concerned that recent 10% rise in blood pressure (BP) was also possibly being driven by the Hashimoto’s, but was not keen to increase BP medication until Thyroid issue addressed.

GP eventually agreed to next steps based on his request to Endocrinology for advice and guidance, which they provided as (very promptly by email):

“If his TFTs show subclinical hypothyroidism then this resource will be helpful in answering your query

nice.org.uk/guidance/ng145/... subclinical-hypothyroidism (Section 1.5)

Surgery practice staff advised today that, based on Endocrinology advice, a 3-6 month trial of 50mg Levothroxine is authorised, to continue if symptoms settle. Was told it is advised there is a “4% annual risk of developing hypothyroidism”, which seems to be the rate for women based on this NICE CKS document:

Hypothyroidism: What is the prognosis?

cks.nice.org.uk/topics/hypo...

I then spoke with the Practice Pharmacist who supported my request for TFT bloods to be retested before 6 months (arranged for end of Jan 25 at 0900hrs) so that initial 50mg dose could be assessed as required. I’ll also do a private test beforehand on the same day for T3 levels, just in case Practice cannot get this from the NHS TFT test.

As advised on here, will also now focus on improving/optimising vitamin D and B12 levels (GP not interested as test results are not deficient).

I think this is probably a decent enough outcome for now, given the circumstances and my impression that the GP was not really au fait with Thyroiditis, and totally hamstrung by local ICB policy. I realise that the real battle will likely come at the end of January. But at least we are up and running and l am looking forward to (hopefully) a few weeks of improvement.

If there is anything else I should consider, I am very happy to take all advice.

Many thanks again for all the help and information.

——————

Male 64

Weight 120kg

NHS Thyroid Function Test on 21 Oct 24 @ 1830hrs

-TSH 5 miu/L (Range 0.35-4.7) [106.90%] [Elevated]

-Free T4 8.7 pmol/L (Range 7.8-21) [6.82%] [Low end of normal]

-Thyroid peroxidase antibodies (TPOab) >1000 iu/ml (Range 0-75) [Very high]

Private Test on 18 Nov 24 @ 0830hrs

-TSH 9.340 mIU/L (Range: 0.27 - 4.2) [230.79%] [Elevated]

-Free T3 4.5 pmol/L (Range: 3.1 - 6.8) [37.84%] [Not optimised]

-Free Thyroxine (F4) 10.2 pmol/L (Range: 12 - 22) [18%] [Low]

-Thyroglobulin Antibodies (TgAb) 446.00 kIU/L (Range: 0 - 115) [Very high]

-Thyroid Peroxidase Antibodies (TPOab) >600 kIU/L (Range: 0 - 34) [Very high]

-Ferritin 97.70 ug/L (Range: 30 - 518) [OK?]

-Folate - Serum 33.1 nmol/L (Range: > 7) [Excellent]

-Vitamin B12 (Active) 76.4 pmol/L (Range: > 37.5) [Low end normal]

--Vitamin D 43.3 nmol/L (Range: 50 - 250) [Insufficient]

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6 Replies
TiggerMe profile image
TiggerMeAmbassador

This sounds like you have triumphed 👏 after January retest be ready to push for a 25mcg increase

This is a great calculator for Vit D dosing always use one that includes K2 MK7, also good to add magnesium as this helps uptake

grassrootshealth.net/projec...

Flamborian profile image
Flamborian in reply toTiggerMe

Thank you. That's very useful

SlowDragon profile image
SlowDragonAmbassador

well done

What vitamin supplements are you currently taking

Aim to improve vitamin D to at least over 80nmol

Gluten

Poor gut function can lead leaky gut (literally holes in gut wall) this can cause food intolerances.

Most common by far is gluten.

Dairy is second most common.

A trial of strictly gluten free diet is always worth doing

Only 5% of Hashimoto’s patients test positive for coeliac but a further 81% of Hashimoto’s patients who try gluten free diet find noticeable or significant improvement or find it’s essential

A strictly gluten free diet helps or is essential due to gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and may slowly lower TPO antibodies

While still eating high gluten diet ask GP for coeliac blood test first as per NICE Guidelines

nice.org.uk/guidance/ng20/c...

Or buy a test online, about £20

Assuming test is negative you can immediately go on strictly gluten free diet 

(If test is positive you will need to remain on high gluten diet until endoscopy, maximum 6 weeks wait officially) 

Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse

chriskresser.com/the-gluten...

amymyersmd.com/2018/04/3-re...

thyroidpharmacist.com/artic...

drknews.com/changing-your-d...

Non Coeliac Gluten sensitivity (NCGS) and autoimmune disease

pubmed.ncbi.nlm.nih.gov/296...

The predominance of Hashimoto thyroiditis represents an interesting finding, since it has been indirectly confirmed by an Italian study, showing that autoimmune thyroid disease is a risk factor for the evolution towards NCGS in a group of patients with minimal duodenal inflammation. On these bases, an autoimmune stigma in NCGS is strongly supported

nuclmed.gr/wp/wp-content/up...

In summary, whereas it is not yet clear whether a gluten free diet can prevent autoimmune diseases, it is worth mentioning that HT patients with or without CD benefit from a diet low in gluten as far as the progression and the potential disease complications are concerned

restartmed.com/hashimotos-g...

Despite the fact that 5-10% of patients have Celiac disease, in my experience and in the experience of many other physicians, at least 80% + of patients with Hashimoto's who go gluten-free notice a reduction in their symptoms almost immediately.

Similarly few months later consider trying dairy free too. Approx 50-60% find dairy free beneficial

With loads of vegan dairy alternatives these days it’s not as difficult as in the past

Post discussing gluten

healthunlocked.com/thyroidu...

Recent research in China into food intolerances with Hashimoto’s

healthunlocked.com/thyroidu...

More interesting Chinese research on Hashimoto’s and leaky gut

nature.com/articles/s41598-...

Flamborian profile image
Flamborian in reply toSlowDragon

@Slowdragon

Thank you. I’ll have a read up about gluten and coeliac’s.

What vitamin supplements are you currently taking

None. Was taking a supermarket Multi-vitamin with minerals (for years) but have heeded advice on here and stopped that. Looking to get some B12 drops and D3 (maybe with + K2 Mk7). I do take low dose Aspirin as a blood thinner (cannot tolerate Clopidogrel) and just researching whether I should avoid vitamin K as a result.

Regenallotment profile image
RegenallotmentAmbassador

good work, but that 6 month on 50mcg bit made me go 😳

As mentioned definitely heed the advice to get bloods every 6-8 weeks and keep upping by 25mcg accordingly. Blokes can pile in and advise but my guess is you will end up on closer to 200mcg based on your weight.

You might feel worse before you feel better.

We’ve been there 👍

Flamborian profile image
Flamborian in reply toRegenallotment

Many thanks. I am also expecting a lengthy titration.

The 6 months on 50mcg is straight from the NICE Guidance NG145 (see 1.5.4 & 1.3.7) for adults with a history of cardiovascular disease (I have a prosthetic aortic valve and a graft for aortic aneurysm).

[NG145] Thyroid disease: assessment and management

nice.org.uk/guidance/ng145/...

I managed to get a blood test after 8 weeks (with Pharmacist support) based on the 6-8 weeks advice on here. However, the NICE NG145 Guideline is every 3 months (See 1.4.3).

I am not really entitled to start a trial yet, as the two initial blood tests I had were not 3 months apart (see NG145 1.5.3 & 1.5.4). I think what made the difference was the additional Lipid test information, that my blood tests followed a Cardiac PET scan showing a hot area in my thyroid, and how significantly elevated the thyroid antibodies were.

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