High t4 low t3 osteoporosis

[Ganggywaller]

Hi , anyone of you lovely people have any infoI was diagnosed last week with quite bad osteoporosis on a dexa scan i have had high t4 and low t3 for many years due to bad cobversion.. just wondered if anyone had experience with this. The only reason i had a dexa scan was because i was due to trial t3 . Any info would be greatly appreciated

[SlowDragon Administrator]

Osteoporosis and LOW Ft3

thyroidpatients.ca/2018/07/...

Low Ft3 frequently results in low stomach acid, this then results in poor nutrient absorption and low vitamin levels

Essential to maintain GOOD vitamin D, magnesium, folate, B12 and ferritin

Osteoporosis and iron deficiency

healthunlocked.com/thyroidu...

[holyshedballs]

Not T3 I know but TSH which may help with your discussions.

There is research to show that low T3 can cause osteoporosis but I cant find it now.

Journal of Bone and Mineral Research, Vol. 33, No. 7, July 2018, pp 1318–1325

DOI: 10.1002/jbmr.3426

Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study

Nicolien A van Vliet,1 Raymond Noordam,1 Jan B van Klinken,2 Rudi GJ Westendorp,1,3

JH Duncan Bassett,4 Graham R Williams,4 and Diana van Heemst1

1 Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands

2 Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands

3 Department of Public Health and Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark

4 Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

ABSTRACT

With population aging, prevalence of low bone mineral density (BMD) and associated fracture risk are increased. To determine whether low circulating thyroid stimulating hormone (TSH) levels within the normal range are causally related to BMD, we conducted a two-sample Mendelian randomization (MR) study. Furthermore, we tested whether common genetic variants in the TSH receptor (TSHR) gene and genetic variants influencing expression of TSHR (expression quantitative trait loci [eQTLs]) are associated with BMD. For both analyses, we used summary-level data of genomewide association studies (GWASs) investigating BMD of the femoral neck (n.32,735) and the lumbar spine (n.28,498) in cohorts of European ancestry from the Genetic Factors of Osteoporosis (GEFOS) Consortium. For the MR study, we selected 20 genetic variants that were previously identified for circulating TSH levels in a GWAS meta-analysis (n.26,420). All independent genetic instruments for TSH were combined in analyses for both femoral neck and lumbar spine BMD. In these studies, we found no evidence that a genetically determined 1–standard deviation (SD) decrease in circulating TSH concentration was associated with femoral neck BMD (0.003 SD decrease in BMD per SD decrease of TSH; 95% CI, –0.053 to 0.048; p.0.92) or lumbar spine BMD (0.010 SD decrease in BMD per SD decrease of TSH; 95% CI, 0.069 to 0.049; p.0.73). A total of 706 common genetic variants have been mapped to the TSHR locus and expression loci for TSHR. However, none of these genetic variants were associated with BMD at the femoral neck or lumbar spine. In conclusion, we found no evidence for a causal effect of circulating TSH on BMD, nor did we find any association between genetic variation at the TSHR locus or expression thereof and BMD. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals, Inc.