Solution to extremely high TPO Ab?: Hi, I... - Thyroid UK

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Solution to extremely high TPO Ab?

Lotus77 profile image
5 Replies

Hi, I previously posted my NHS and private blood results and still learning to find my solution to very high TPO (933).

Just in my simple brain, if your antibodies are attacking the body, they attack good & bad and thus won’t absorb vitamins/nutrients/medication?

I feel a bit overwhelmed for the best way forward, understanding it might be trial and error.

I had increased all supplements for a while, but TPO just getting worse, likely due to pre-menopausal hormonal changes (?).

I’ll speak to GP Monday and wonder if have to request increase meds again, and perhaps before topping up on all deficiencies?

Also I read about AIP (Autoimmune Protocol), anyone positive results?

Thank you for your support 🙏🏼

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SlowDragon profile image
SlowDragonAdministrator

previous post

healthunlocked.com/thyroidu...

shows you are in need of dose increase in Levo

Get full iron panel test

And improve vitamin levels

Have you had coeliac blood test yet

SlowDragon profile image
SlowDragonAdministrator

Hashimoto's affects the gut and leads to low stomach acid and then low vitamin levels

Low vitamin levels affect Thyroid hormone working

Poor gut function can lead leaky gut (literally holes in gut wall) this can cause food intolerances.

Most common by far is gluten.

Dairy is second most common.

A trial of strictly gluten free diet is always worth doing

Only 5% of Hashimoto’s patients test positive for coeliac but a further 81% of Hashimoto’s patients who try gluten free diet find noticeable or significant improvement or find it’s essential

A strictly gluten free diet helps or is essential due to gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and may slowly lower TPO antibodies

While still eating high gluten diet ask GP for coeliac blood test first as per NICE Guidelines

nice.org.uk/guidance/ng20/c...

Or buy a test online, about £20

Assuming test is negative you can immediately go on strictly gluten free diet 

(If test is positive you will need to remain on high gluten diet until endoscopy, maximum 6 weeks wait officially) 

Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse

chriskresser.com/the-gluten...

amymyersmd.com/2018/04/3-re...

thyroidpharmacist.com/artic...

drknews.com/changing-your-d...

Non Coeliac Gluten sensitivity (NCGS) and autoimmune disease

pubmed.ncbi.nlm.nih.gov/296...

The predominance of Hashimoto thyroiditis represents an interesting finding, since it has been indirectly confirmed by an Italian study, showing that autoimmune thyroid disease is a risk factor for the evolution towards NCGS in a group of patients with minimal duodenal inflammation. On these bases, an autoimmune stigma in NCGS is strongly supported

nuclmed.gr/wp/wp-content/up...

In summary, whereas it is not yet clear whether a gluten free diet can prevent autoimmune diseases, it is worth mentioning that HT patients with or without CD benefit from a diet low in gluten as far as the progression and the potential disease complications are concerned

restartmed.com/hashimotos-g...

Despite the fact that 5-10% of patients have Celiac disease, in my experience and in the experience of many other physicians, at least 80% + of patients with Hashimoto's who go gluten-free notice a reduction in their symptoms almost immediately.

Similarly few months later consider trying dairy free too. Approx 50-60% find dairy free beneficial

With loads of vegan dairy alternatives these days it’s not as difficult as in the past

Post discussing gluten

healthunlocked.com/thyroidu...

greygoose profile image
greygoose

There is not solution to high TPO antibodies. Nor do you need one. They are not - I repeat NOT - attacking your thyroid.

Off-hand, I can't remember the name of what is doing the attacking, but all antibodies are very specific. They only attack what they're supposed to attack. TPO antibodies 'attack' - but it's more like cleaning up - the traces of TPO that leak into the blood during an attack on your thyroid. TPO - Thyroid Peroxidase - is a protein found within the thyroid essential to the production of thyroid hormones. It is not supposed to be in the blood, so the antibodies get rid of it. They are the bodies Mrs Mops. And they have nothing to do with absorption of nutrients.

These antibodies fluctuate all the time - nothing to do with the menopause. They are likely to be highest just after an immune system attack on the thyroid, when they come along in force to clean up the blood. When the job is done, the numbers reduce. You are not going to get rid of your Hashi's by reducing antibodies - if such a thing were even possible - but they do reduce in number as the thyroid gets smaller meaning less attacking so less work for them to do. So, don't worry about them. They are your friends, not your enemies. :)

helvella profile image
helvellaAdministrator in reply togreygoose

This post of mine from a while back goes into very great detail about exactly what happens.

It is a VERY tough read. But even a skim shows that the hyper-simplistic "antibody attack" story is woeful.

Unraveling the molecular architecture of autoimmune thyroid diseases at spatial resolution

healthunlocked.com/thyroidu...

greygoose profile image
greygoose

I didn't say nothing was attacking your thyroid, I said the TPO antibodies weren't attacking it. But your immune system is slowly destroying it.

Yes, you do need an increase in dose. :)

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