I am hypothyroid since approximately 1987, self diagnosed! Recently I have noticed an increase in low mood, hot flushes and cramps. I am 76 yrs old but still the hot flushes persist.
I get very tired and also get tingling in my hands which starts in the mornings. I take Levothyroxine 100/125mcgs alternate days. My last blood results from GP were:
SerumTSH 1.38mU/L 0.30-4.40
Serum free T4 level 13.7pmol/L 8.9-17.3
These were taken in January 2024
I am also on Escitalopram 15mgs daily: and Mirtazapine 15mgs nocte. Also Diazepam 5mg b.d.
These may be responsible for the fatigue, parasthesia, and muscle and joint aches. I know these medications probably put me into the depression app on health Unlocked but wanted to ask if something autoimmune could be responsible for my low mood and symptoms
I always explore the thyroid first, and then move on as required.
Any advice would be hugely appreciated!
P.S I do not hyperventilate when tingling occurs!
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I get cramp at lot in my feet & toes esp.if anything touches them,like sheets tucked in tight,even when trying shoes on in the shop arghh! Think its part of the thyroid
You're probably under-medicated with an FT4 only 57 % through the range - should probably be more like 75%! And if your FT4 is too low, your FT3 is going to be even lower, and that's what causes symptoms.
Having said that, your symptoms sound as if they could be due to nutritional deficiencies - which most hypos have. So, have you had your vit D, vit B12, folate and ferritin tested? If not, I would suggest you ask your doctor to test them.
I forgot to mention I am on Vitamin B 12 inj every three months having had a level of 180 (130 -900) two years ago. Thanks to you and your colleagues it was flagged up as being extremely low! So grateful to you!
No point in retesting that as already on supplement.
Last serum Ferritin : 52ug/L (15-300)
I gA 2.37g/L (0.80-4.00)
Total 25-hydroxyvitamin D level 96nmol/L
Serum free T3 level 3.1pmol/L (2.4-6.0)
These were taken in August 2023. Apparently folate was in the normal to high range but cannot find the result, sorry.
I hope this is helpful to you as I feel I am drowning under a sea of antidepressants!
That's why you're depressed! Your FT3 is far too low. You don't need antidepressants, you need T3.
That said, before chasing after T3, try increasing your levo - perhaps a coupld of times at six week intervals. See if that raises your FT3 high enough to make you well.
If you're having B12 injections, are you also taking a daily B complex? The Bs all work together so need to be kept balanced. Just taking one isolated B vit won't do much for you.
Last serum Ferritin : 52ug/L (15-300)
Much too low! You need to get a full iron panel done.
Do you take Levo on it’s own well away from other medications
Levothyroxine is an extremely fussy hormone and should always be taken on an empty stomach and then nothing apart from water for at least an hour after
Many people take Levothyroxine soon after waking, but it may be more convenient and perhaps more effective taken at bedtime
But presumably you are taking Mirtazapine at bedtime
No other medication or supplements at same as Levothyroxine, leave at least 2 hour gap.
Some like iron, calcium, magnesium, HRT, omeprazole or vitamin D should be four hours away
(Time gap doesn't apply to Vitamin D mouth spray)
If you normally take levothyroxine at bedtime/in night ...adjust timings as follows prior to blood test
If testing Monday morning, delay Saturday evening dose levothyroxine until Sunday morning. Delay Sunday evening dose levothyroxine until after blood test on Monday morning. Take Monday evening dose levothyroxine as per normal
Do you always get same brand levothyroxine at each prescription
Recommended that all thyroid blood tests early morning, ideally just before 9am, only drink water between waking and test and last dose levothyroxine 24 hours before test
This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)
Bloods should be retested 6-8 weeks after each dose change or brand change in levothyroxine, or if you change how you take it
For full Thyroid evaluation you need TSH, FT4 and FT3 tested
Also both TPO and TG thyroid antibodies tested at least once to see if your hypothyroidism is autoimmune
Very important to test vitamin D, folate, ferritin and B12 at least once year minimum
Low vitamin levels are extremely common when hypothyroid, especially with autoimmune thyroid disease and especially as we get older
Exactly what vitamin supplements are you taking
When were vitamin levels last tested
Assuming you tested correctly, your results suggest you are not on high enough dose levothyroxine
Spoke to my GP re: your and Grey Goose’s suggestions.
Extremely unhelpful response which didn’t help one bit. I was respectful of her professional status, but I do wonder if GP’s feel threatened by patients who ask for help using your in depth knowledge of thyroid conditions.
At least at the end I got a blood test for TSH, FreeT4 , and Free T3 plus cholesterol/ triglyceride levels tomorrow morning. She has also agreed to up my Levothyroxine from 100mcgs/ 125mcgs alt die, to 125mcgs od and retest in 6-8 weeks.
The iron panel I will have to do privately as NHS doesn’t do it.
I shall also order some Vitamin B complex to go alongside my Vitamin B12 injections.
As an ex ward sister I would never have been so prickly with my patients. Perhaps she was having a bad day!!
I have ordered a full iron panel from medichecks to start.
This morning had TSH, FreeT4 and free T3 plus Cholesterol and triglycerides plus Ferritin . All fasting and last Levothyroxine early yesterday morning.
Had ultrasound scan of thyroid in 2018 NAD.
TPA done 2018 =3 U/ml (less than (6,0)
Has TPO done but am looking for my result and will inform.
Magnesium=0.85 but don’t know range!
My Vitamin B12 inj are two monthly after a request
Is it safe to take Vitamin B Complex when already on Vitamin B12 inj?
A trial of strictly gluten free diet is always worth doing
Only 5% of Hashimoto’s patients test positive for coeliac but a further 81% of Hashimoto’s patients who try gluten free diet find noticeable or significant improvement or find it’s essential
A strictly gluten free diet helps or is essential due to gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)
Changing to a strictly gluten free diet may help reduce symptoms, help gut heal
As your coeliac test is negative you can consider going on strictly gluten free diet
Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse
The predominance of Hashimoto thyroiditis represents an interesting finding, since it has been indirectly confirmed by an Italian study, showing that autoimmune thyroid disease is a risk factor for the evolution towards NCGS in a group of patients with minimal duodenal inflammation. On these bases, an autoimmune stigma in NCGS is strongly supported
In summary, whereas it is not yet clear whether a gluten free diet can prevent autoimmune diseases, it is worth mentioning that HT patients with or without CD benefit from a diet low in gluten as far as the progression and the potential disease complications are concerned
Despite the fact that 5-10% of patients have Celiac disease, in my experience and in the experience of many other physicians, at least 80% + of patients with Hashimoto's who go gluten-free notice a reduction in their symptoms almost immediately.
Similarly few months later consider trying dairy free too. Approx 50-60% find dairy free beneficial
With loads of vegan dairy alternatives these days it’s not as difficult as in the past
Eating iron rich foods like liver or liver pate once a week plus other red meat, pumpkin seeds and dark chocolate, plus daily orange juice or other vitamin C rich drink can help improve iron absorption
Thank you for your incredible patience while you have been awaiting the outcome of our ferritin reference range review. We conducted this with Inuvi lab, which has now changed the reference ranges to the following:
Females 18 ≤ age < 40. 30 to 180
Females 40 ≤ age < 50. 30 to 207
Females 50 ≤ age < 60. 30 to 264l
Females Age ≥ 60. 30 to 332
Males 18 ≤ age < 40 30 to 442
Males Age ≥ 40 30 to 518
The lower limits of 30 are by the NICE threshold of <30 for iron deficiency. Our review of Medichecks data has determined the upper limits. This retrospective study used a large dataset of blood test results from 25,425 healthy participants aged 18 to 97 over seven years. This is the most extensive study on ferritin reference ranges, and we hope to achieve journal publication so that these ranges can be applied more widely.
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Hashimoto’s, leg cramps, ankles and feet really stiff and feel bruised.
Hot flushes on and off on thyroid-s 
Flushing and low thyroid
Hot flushes
