Thyroxine-binding globulin: Hi, Please note I... - Thyroid UK

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Thyroxine-binding globulin

ValDee88 profile image
9 Replies

Hi,

Please note I have not had a Thyroid diagnosis and am not on any meds. As part of a well woman check I had thyroid blood tests. Results are as follows-

TSH-1.72 mlU/L (0.35-5.5)

FT4-17.9 pmol/l (11.9-21.6)

FT3-4.92 pmol/l (3.1-6.8)

Anti-Tg-115.0)

Anti-TPO-34.0)

TBG-24.5ug/ml (6.3-22.7)

The only one flagged is the last one-TBG. The notes said that although this was high, it didnt mean anything as the other results were fine and I dont fall into the other categories mentioned ie Im not pregnant or on HRT, so what does it actually do? Thanks for any info 🙂

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ValDee88
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Forestgarden profile image
Forestgarden

TBG is thyroxine binding globulin. It binds with the thyroid hormones (T3 and T4) and transports them in the bloodstream. Its used to aid diagnosis of thyroid conditions when FT3 (free T3) and FT4 (free T4) are not within the normal range. The FT3 and FT4 are the important numbers as far as thyroid issues go. I think there are a few reasons why TBG can be raised, but you are only a little over range, and as long as you feel well I wouldn't worry about it. NB: I'm not a doctor!

SlowDragon profile image
SlowDragonAdministrator

what were TPO and TG results

Did you test vitamin D, folate, ferritin and B12

ValDee88 profile image
ValDee88 in reply toSlowDragon

Sorry, no idea why they didnt show. TG-10.01 and TPO-7.45.

Vit D was 81 (50-375)

B12-411 (197-771-ng/L)

Folate-9.1ug/l (3.8-26.8)

Ferritin-58.99 ug/l (10-120)

Vit D is better than normal as Ive been using the BetterYou +K2 spray.

SlowDragon profile image
SlowDragonAdministrator in reply toValDee88

Why did you get tested

Do you have symptoms

B12 and folate on low side

Low B12 symptoms

b12deficiency.info/signs-an...

methyl-life.com/blogs/defic...

With serum B12 result below 500, (Or active B12 below 70) recommended to be taking a separate B12 supplement

A week later add a separate vitamin B Complex 

Then once your serum B12 is over 500 (or Active B12 level has reached 70), you may be able to reduce then stop the B12 and just carry on with the B Complex.

If Vegetarian or vegan likely to need ongoing separate B12 few times a week

Highly effective B12 drops

natureprovides.com/products...

Or

B12 sublingual lozenges

uk.iherb.com/pr/jarrow-form...

cytoplan.co.uk/shop-by-prod...

B12 range in U.K. is too wide

Interesting that in this research B12 below 400 is considered inadequate

healthunlocked.com/thyroidu...

Low folate

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid)

This can help keep all B vitamins in balance and will help improve B12 levels too

Difference between folate and folic acid

healthline.com/nutrition/fo...

Many Hashimoto’s patients have MTHFR gene variation and can have trouble processing folic acid.

thyroidpharmacist.com/artic...

B vitamins best taken after breakfast

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule)

Thorne currently difficult to find at reasonable price, should be around £20-£25. iherb.com often have in stock. Or try ebay

Igennus B complex popular option too. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose

Post discussing different B complex

healthunlocked.com/thyroidu...

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg) and continue separate B12

Post discussing how biotin can affect test results

healthunlocked.com/thyroidu...

helvella.blogspot.com/p/hel...

ValDee88 profile image
ValDee88 in reply toSlowDragon

I have a lot of symptoms so Ive just had a well woman check, which contained a thyroid panel. I suspect a lot of my issues stem from long term low/deficient B12, D and folate. Thank you so much for all of this info, it is incredibly helpful 👍

SlowDragon profile image
SlowDragonAdministrator in reply toValDee88

Retest thyroid and vitamin levels in say 3-4 months

Ferritin might be better nearer 100

Look at increasing iron rich foods in diet

Eating iron rich foods like liver or liver pate once a week plus other red meat, pumpkin seeds and dark chocolate, plus daily orange juice or other vitamin C rich drink can help improve iron absorption

List of iron rich foods

dailyiron.net

SilverAvocado profile image
SilverAvocado

I am not familiar with how to interpret thyroxine binding globulin. It hardly ever comes up, and I'm a bit surprised it was included in a well woman check up. I've never had it tested (just checked my records), and have had serious thyroid issues for over a decade.

I just wanted to mention that your thyroid panel blood tests (TSH, freeT4 and freeT3) all look excellent. It is quite interesting to see a healthy set of results, as we usually see results from failing thyroids.

TSH stands for thyroid stimulating hormone, it is a hormone that increases when the body needs more thyroid hormone, to call on the thyroid to make more. A healthy number is around about 1-1.7 . Both freeT4 and freeT3 are measures of how much hormone is available in your blood. For both of these the range given is a normal curve, which means most healthy people will have results near the middle of the range. The closer to the extreme ends of the range you are the less likely you are to have a healthy thyroid. Yours both look nice and close to the centre.

These results show that at the moment your thyroid is performing great, and doing what you need it to do.

Just a noted for anyone besides the original poster who might be reading. These results are great for a healthy thyroid on no medication. But once you are ill and taking thyroid hormone replacement, ideal results are quite different. Replacement hormone does not work in the same way as natural hormone produced by our own thyroid gland.

ValDee88 profile image
ValDee88 in reply toSilverAvocado

Thank you for the info 🙂

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Batty1

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