TSH higher after stopping Biotin: After decades... - Thyroid UK

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TSH higher after stopping Biotin

topazrat profile image
8 Replies

After decades of telling my doctor that I have all the symptoms of hypothyroidism and being told everything was normal as TSH was between 2.8 and 4 [0.38 - 5.33], I discovered a few weeks back that the Biotin supplement that I have been taking for all of that time could have been interferring with the results. Doctor never told me this, even though they knew I was taking supplements! I have been feeling worse and worse over the last year. So, after stopping it for a week, I took a medichecks test and these are the results. Autoimmunity results are both nice and low. Last test at the docs was 3.24 on 14th December.

They just keep telling me that symptoms are caused by stress and depression, which I dispute as being untrue. I also have autoimmune P.A., psoriasis, eczema, asthma, multiple allergies and diabetes.

I'm still under the G.P, reference range, but I'm getting desperate for help now, so wish me luck.

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SlowDragon profile image
SlowDragonAdministrator

so you need to test thyroid antibodies and vitamin levels next

both TPO and TG thyroid antibodies tested at least once

Very important to test vitamin D, folate, ferritin and B12 at least once year minimum

About 90% of primary hypothyroidism is autoimmune thyroid disease, usually diagnosed by high thyroid antibodies

Autoimmune thyroid disease with goitre is Hashimoto’s

Autoimmune thyroid disease without goitre is Ord’s thyroiditis.

Both are autoimmune and generally called Hashimoto’s.

Significant minority of Hashimoto’s patients only have high TG antibodies (thyroglobulin)

Low vitamin levels are extremely common when hypothyroid, especially with autoimmune thyroid disease

20% of autoimmune thyroid patients never have high thyroid antibodies and ultrasound scan of thyroid can get diagnosis

In U.K. medics hardly ever refer to autoimmune thyroid disease as Hashimoto’s (or Ord’s thyroiditis)

Recommended that all thyroid blood tests early morning, ideally just before 9am, only drink water between waking and test

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

Private tests are available as NHS currently rarely tests Ft3 or all relevant vitamins

Testing options and includes money off codes for private testing

thyroiduk.org/testing/

Medichecks Thyroid plus antibodies and vitamins

medichecks.com/products/adv...

Blue Horizon Thyroid Premium Gold includes antibodies, cortisol and vitamins

bluehorizonbloodtests.co.uk...

Only do private testing early Monday or Tuesday morning.

Link about thyroid blood tests

thyroiduk.org/testing/thyro...

Link about Hashimoto’s

thyroiduk.org/hypothyroid-b...

Symptoms of hypothyroidism

thyroiduk.org/signs-and-sym...

Tips on how to do DIY finger prick test

support.medichecks.com/hc/e...

Medichecks and BH also offer private blood draw at clinic near you, or private nurse to your own home…..for an extra fee

topazrat profile image
topazrat in reply to SlowDragon

Antibodies are normal and low in range. B12, I inject weekly, Vitamin D is around 70 nmol/L (can't find most recent result), Ferritin is 33 ng/mL (11.0 - 307.0, Folate > 24.8 ug/L [3.1 - 19.9]Have started on Gentle iron to try to increase Ferritin.

SlowDragon profile image
SlowDragonAdministrator in reply to topazrat

Have you tested BOTH TPO and TG antibodies

And had ultrasound scan of thyroid

Ferritin very poor, virtually deficient

Gentle iron unlikely to increase levels much

Are you vegetarian or vegan

Pre or post menopause

cks.nice.org.uk/topics/anae...

Serum ferritin level is the biochemical test, which most reliably correlates with relative total body iron stores. In all people, a serum ferritin level of less than 30 micrograms/L confirms the diagnosis of iron deficiency.

Never supplement iron without doing full iron panel test for anaemia first and retest 3-4 times a year if self supplementing. It’s possible to have low ferritin but high iron

Test early morning, only water to drink between waking and test. Avoid high iron rich dinner night before test

Medichecks iron panel test

medichecks.com/products/iro...

Look at increasing iron rich foods in diet

Eating iron rich foods like liver or liver pate once a week plus other red meat, pumpkin seeds and dark chocolate, plus daily orange juice or other vitamin C rich drink can help improve iron absorption

List of iron rich foods

dailyiron.net

Links about iron and ferritin

irondisorders.org/too-littl...

davidg170.sg-host.com/wp-co...

Great in-depth article on low ferritin

oatext.com/iron-deficiency-...

drhedberg.com/ferritin-hypo...

This is interesting because I have noticed that many patients with Hashimoto’s disease and hypothyroidism, start to feel worse when their ferritin drops below 80 and usually there is hair loss when it drops below 50.

healthunlocked.com/thyroidu...

Posts discussing Three Arrows as very effective supplement

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

Iron patches

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

restartmed.com/hypothyroidi...

Post discussing just how long it can take to raise low ferritin

healthunlocked.com/thyroidu...

Iron and thyroid link

healthunlocked.com/thyroidu...

Posts discussing why important to do full iron panel test

healthunlocked.com/thyroidu...

Good iron but low ferritin

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

Chicken livers if iron is good, but ferritin low

healthunlocked.com/thyroidu...

Shellfish and Mussels are excellent source of iron

healthline.com/nutrition/he...

Iron deficiency without anaemia

healthunlocked.com/thyroidu...

Ferritin over 100 to alleviate symptoms

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

Great research article discussing similar…..ferritin over 100 often necessary

ncbi.nlm.nih.gov/pmc/articl...

Low Iron implicated in hypothyroidism

healthunlocked.com/thyroidu...

Inflammation affecting ferritin

healthunlocked.com/thyroidu...

Updated reference ranges for top of ferritin range depending upon age

healthunlocked.com/thyroidu...

Thank you for your incredible patience while you have been awaiting the outcome of our ferritin reference range review. We conducted this with Inuvi lab, which has now changed the reference ranges to the following:

Females 18 ≤ age < 40 30 to 180

Females 40 ≤ age < 50 30 to 207

Females 50 ≤ age < 60 30 to 264

Females Age ≥ 60 30 to 332

Males 18 ≤ age < 40 30 to 442

Males Age ≥ 40 30 to 518

The lower limits of 30 are by the NICE threshold of <30 for iron deficiency. Our review of Medichecks data has determined the upper limits. This retrospective study used a large dataset of blood test results from 25,425 healthy participants aged 18 to 97 over seven years. This is the most extensive study on ferritin reference ranges, and we hope to achieve journal publication so that these ranges can be applied more widely.

SlowDragon profile image
SlowDragonAdministrator in reply to topazrat

B12 injections

Do you have Pernicious Anaemia?

As you do B12 injections it’s recommended also to supplement a good quality daily vitamin B complex, one with folate in (not folic acid) may be beneficial.

This can help keep all B vitamins in balance

Difference between folate and folic acid

healthline.com/nutrition/fo...

B vitamins best taken after breakfast

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule)

Thorne currently difficult to find at reasonable price, should be around £20-£25. iherb.com often have in stock. Or try ebay

Igennus B complex popular option too. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose

Post discussing different B complex

healthunlocked.com/thyroidu...

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg)

Post discussing how biotin can affect test results

healthunlocked.com/thyroidu...

helvella.blogspot.com/p/hel...

topazrat profile image
topazrat

THYROGLOBULIN ANTIBODIES 15.7 kIU/L (0 - 115 )

THYROID PEROXIDASE ANTIBODIES <9 kIU/L (0 - 34)

Yes, I have autoimmune P.A. with positive IFaB and parietal antibodies. I take B complex, gentle iron, vit D and magnesium.

No scans because G.P. will not acknowledge that I have a thyroid problem. Diet is normal, well balanced. Post menopause. Ferritin was 5 when diagnosed with P.A. Went up to 60 after a course of iron to correct megloblastic anemia. and has been drifting down slowly since. Iron panel has not been done since P.A diagnosis in 2016, as Doc doesn't think it is needed, cos everything is in normal range! 😟 Hair has been falling out in handfulls for months.

SlowDragon profile image
SlowDragonAdministrator in reply to topazrat

So as you have PA (autoimmune) it’s likely thyroid is autoimmune too

So look at getting ultrasound scan yourself

Roughly where in U.K. are you

thyroiduk.org/testing/other...

thyroiduk.org/testing/priva...

Hair has been falling out in handfulls for months.

Strongly suggests iron/ferritin too low

topazrat profile image
topazrat in reply to SlowDragon

I'm in the South West, but I am not in a position to either travel or afford private testing at the moment, so I am stuck with NHS for now.

Forestgarden profile image
Forestgarden

Hopefully your gp will retest your tsh now, once you've explained about the biotin. Tell gp to google it! Or take a printout ncbi.nlm.nih.gov/pmc/articl... .Good luck!

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