Updated bloods

[MPG15]

Hello

I had some updated bloods done in September (just about to retake on 8 Jan).

My thyroglobulin has increased from 239 in April to 289 in Sept (although TSH has lowered from 4.1) . I am having increased symptoms fatigue, hair fall, dry skin, nails peeling, cracked heels, generally feeling rubbish. Also have tight feeling around my neck almost like glands are up but they’re not, this is new). Am awaiting an appointment with endocrinologist at the Marsden (I am a patient as have just recovered from stage III bowel cancer) though not suspecting thyroid cancer just my oncologist referring me to him as he’s on site).

Tests were done by Medichecks and it is the second time they have mentioned Hashimotos in their notes. This would tie in with another autoimmune condition I have “Spontaneous Idioathic Urticaria and Angioedema” (basically hives/itching/tongue swelling with no known cause). Diagnosed 2017. I seem to consistently have raised CRP too. Bloods also show poss on cusp of anaemia, below level lymphocytes, low neutrophils and white cell count.

I know endocrinologist will do his own tests but am trying to keep regular tests to see my overall health post cancer etc.

I attach results and would greatly appreciate any thoughts/advice.

thank you!

THYROGLOBULIN ANTIBODIES 0-115 Range

289 KIU/L

THYROID PEROXIDASE ANTIBODIES 0 - 34 R

<9 KIU/L

TSH 0.27 - 4.2 R

2.93 mIU/L

FREE T3 - 3.1 - 6.8 R

5.2 pmol/L

FREE THYROXINE 12 - 22 R

12.3 pmo/L

CRP <3

8.46 mg/L

FOLATE - SERUM 8.83 - 60.8 R

10.2 nmo/L

VITAMIN B12 -ACTIVE 37.5 - 188 R

79.6 pmo/L

VITAMIN D 50 - 250 R

164 nmo/L

[SlowDragon Administrator]

what vitamin supplements are you taking

Folate is low

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid)

This can help keep all B vitamins in balance and will help improve/maintain B12 levels too

Difference between folate and folic acid

healthline.com/nutrition/fo...

Many Hashimoto’s patients have MTHFR gene variation and can have trouble processing folic acid.

thyroidpharmacist.com/artic...

B vitamins best taken after breakfast

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule)

Thorne currently difficult to find at reasonable price, should be around £20-£25. iherb.com often have in stock. Or try ebay

Igennus B complex popular option too. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose

Post discussing different B complex

healthunlocked.com/thyroidu...

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg)

Post discussing how biotin can affect test results

healthunlocked.com/thyroidu...

helvella.blogspot.com/p/hel...

[MPG15 in reply to SlowDragon]

Dear SlowDragon

Thank you so much for your informed response.

I am currently not taking any supplements whilst my enteritis etc has been investigated and healing and whilst I await my blood tests on 8 January.

Interestingly I have had my DNA reports done and I have a mutation in the MTHFR gene which means I struggle with B2 & B3 absorption and a reduced ability to convert folic acid into a usable form. I am advised B12 for me should be in the form of methylcobalamin. Some years back I used to have regular Vit B injections and magnesium infusions for chronic fatigue syndrome.

I also have TG, CAPZB, CTLA4-GA, TC & AG gene variants which give me a higher risk of hypothyroidism and Hashimotos Also I have the CD40 autoimmune variant causing my immune system to attack my thyroid.

I am also completely missing the GSTM1 gene which means I have no Glutathione (which is usually in every cell in your body helping with anti inflammatory and antioxidant properties).

I certainly show signs of high inflammation throughout my body and stress most of all having just had cancer and now damage to my bone marrow and white and red blood cells.

I am overweight (20kg over my “usual” weight) despite a limited appetite and one meal per day (my intestines/colon struggle to process more food than that). Obviously being more sedentary this past couple of years has not helped whilst I have recovered. And it is difficult to be sure if my constant exhaustion is recovery or thyroid or even malnutrition but certainly the dna reports and bloods indicate certain things are not right. I’ll be interested to see what my next bloods say and the endocrinologist when I get to see him.

It would be good to get back some quality of life

I’ll let you know how I get on.

Thanks again for your wise words and advice much appreciated. If only there were more vitamins and nutrition in a glass of wine! 😂

Best wishes

M

[SlowDragon Administrator]

You may struggle to get Hashimoto’s diagnosed with only high thyroglobulin antibodies

But high TG antibodies causes symptoms

pubmed.ncbi.nlm.nih.gov/303....

ncbi.nlm.nih.gov/pmc/articl...

Our results confirm a high prevalence of autoimmune thyroiditis (20%) in patients with obesity. TgAb may be associated with hypothyroidism in the absence of TPOAb. TgAb measurement may turn helpful to unravel a proportion of subjects that may have or may develop primary hypothyroidism requiring specific substitutive treatment.

Request ultrasound scan of thyroid

Or get your own scan done

thyroiduk.org/testing/other...

thyroiduk.org/testing/priva...