Headlines/chapters of our upcoming eBook

[diogenes]

I thought it might be useful to give TUK readers the chapter headlines we will use in the upcoming eBook, giving an indication of the scope of it and the basic thrust .

Hypothyroidism - Reappraisal of Pathophysiology, Diagnosis and Treatment with Implications for a New Paradigm 1

Foreword 4

Hypothyroidism 6

Definition 6

Epidemiology 7

Etiology 7

Concept of relational stability 13

Thyroid physiology 17

Iodine metabolism 18

Transmembrane transport and intra-cellular effects 19

Mitochondria and T3 actions 22

Deiodinases 23

Hypothalamic-pituitary-thyroid regulation 26

Homeostasis and allostasis 27

The regulatory network of the hypothalamic-pituitary-thyroid axis 30

The functionality of the hypothalamic-pituitary-thyroid axis 34

FT3 homeostasis as a system goal 39

Clinical implications of a FT3-inclusive perspective 46

Memory effects and hysteresis 50

Mechanisms of heath and disease 52

Approach to the patient 64

Symptoms of hypothyroidism 64

History 66

Physical examination 67

Laboratory thyroid function tests 68

Ultrasonography of the thyroid 70

Thyroid scintigraphy 71

Fine needle aspiration 72

Cardiac tests 72

Quality of life assessment 72

Biochemical thyroid function testing 73

The new paradigm for thyroid function diagnosis and treatment; conceptual and technical barriers to consistent outcomes 73

Foreword 73

Thyroid hormone testing: where have we come from? 75

Thyroid Function Testing -where are we now? 78

Fallacies in opposing free thyroid hormone test validity 79

Recommendations for the future 80

Conclusion 82

Diagnosis of hypothyroidism 91

Diagnostic considerations 91

Diagnostic use of TSH 92

TSH reference range 93

Treatment of hypothyroidism 101

Treatment goals 103

Whom to treat 103

How to treat hypothyroidism 104

Treatment effects 107

Issues and controversies in the treatment of hypothyroidism 108

Treatment failure 110

Treatment monitoring 113

Treatment duration 113

Adverse effects 114

Treatment with alternative drugs 115

Nutrition and smoking 119

Special considerations in the treatment of hypothyroidism 122

[Nat107]

Thank you very much Diogenes, looking forward to reading when finished

[Sneedle]

Wow. It's fantastic to see these titles - such clinical, calculated depth I love it!

[helvella Administrator]

That is going to be some read!

Appreciate you posting that, it is quite some teaser.

[TSH110]

sounds most interesting - great work!

[Regenallotment Ambassador]

oh wow, can’t wait!

[tattybogle]

ok .. i'm excited now

i've never bought an e-book , but i'll make an exception for you.

[TiggerMe Ambassador]

Our daily struggles in black and white 😲

A modern day horror / thriller / tearjerker / struggle to survive but ultimately a triumph against the odds...

A must buy for all GP's and Endocrinologists who may have skipped the afternoon lecture at University

[CosmicGirl61 in reply to TiggerMe]

Haha! 🤣🤣 Brilliant 👏👏👏👏

[RedApple Administrator]

Better warn the webmaster of the site that will be offering the download, that there could be mad rush from thousands of TUK forum members on release day! We don't want the site to crash due to sheer weight of traffic 🤣

[CosmicGirl61 in reply to RedApple]

🤣🤣🤣

[jade_s in reply to RedApple]

🤣🤣 we should work out a system - if your handle starts with A-E, you can download on the day it's released. F-J, day 2, and so on ... Sorry RedApple you will be on Day 4 😂😜

[RedApple Administrator in reply to jade_s]

Maybe I'll change my name to AppleRed! 😉

[jade_s in reply to RedApple]

🤣

[StPetes]

Looking forward to this Diogenes. Hope you have a lovely holiday planned following all this important work.

[JGBH]

Thank you… so much to read, absorb and digest. Medical professionals should read it!

[AliF]

Now that is what I call comprehensive. Looking forward to e- publication.

[Fruitandnutcase in reply to AliF]

That’s exactly what I was thinking!

[jamjar67]

Will look forward to reading this, thank you for all the work you do 🙏

[FAB-jellybean]

Sounds really comprehensive. I'll be buying 2 copies I think, one for myself and one for my GP surgery! Thank you Diogenes, this book can't come fast enough for the healthcare profession.

[Tythrop]

Let's hope the NHS Endo Consultants read it ... maybe when they have the time on their strike...Oh sorry no they will be catching up on their private work and then going back to NHS for double - time overtime

[CosmicGirl61 in reply to Tythrop]

Tythrop, that's so funny but true! 😂

[Fruitandnutcase in reply to CosmicGirl61]

No, I think you mean so true but not funny ☹️

[DippyDame]

...just huge thanks!

[CosmicGirl61]

Diogenes, thank you, thank you! You've obviously put a lot of work into this book. The only thyroid book I bought in the early days was by Joan Gomez "How to cope with thyroid problems". The intro stated that you would have to just take a tiny white tablet for the rest of your life, to be ok!! 🙈🙈 If only it were that simple. One thing she did say, which was interesting though and I think true about myself, is that people who usually suffer with thyroid problems tend to be warm, kind hearted people!

Wondering, how will you be spreading the word about your new eBook to the "medical profession?" Do you have a good feeling about your book educating our GPs? I do hope so! Thank you again.

[Fruitandnutcase in reply to CosmicGirl61]

Sorry and I don’t mean anything personal you could well be a warm, kind hearted person but I think Joan Gomez saying ‘ people who usually suffer with thyroid problems tend to be warm, kind hearted people!’ is as batty as her saying ‘that you would have to just take a tiny white tablet for the rest of your life, to be ok!! ’

[CosmicGirl61 in reply to Fruitandnutcase]

Who knows but that's what her book says 🤷🏻‍♀️

[HealthStarDust]

I would have loved some chapters dedicated to preconception, pregnancy and post pregnancy.

[Regenallotment Ambassador in reply to HealthStarDust]

Well spotted, I was misdiagnosed with post partum thyroiditis that was Hashi’s all along. I could have done with knowing more back then and GPs Endos etc knowing more. Mind you ‘puberty to conception through to menopause and your thyroid’ could be a another whole book 📚

[HealthStarDust in reply to Regenallotment]

Sure, and like many of the the chapters that could be a while book too. I just find any wilful ignorance in this area adds to the problem

[diogenes Remembering in reply to HealthStarDust]

Pregnancy will figure in the appropriate chapter on whom to treat. Preconception will stand as a description of "normal euthyroid" patients. Postpartum will also figure here.

[Regenallotment Ambassador in reply to diogenes]

Excellent news!

[Shufflebunnie]

Wow. This is going to be so comprehensive and a great resource for everyone. Thank you so much for the time you've spent and spending to creat this.

[Kityfitz]

I’ll definitely buy this - thanks for the information.

[Delilahmy]

fabulous and so comprehensive. Well done and very excited to see you in print Diogenes

[BB001]

Sounds good. I'll get the ebook. Any plans for a hard back version?

[Zephyrbear]

Thank you so much for this! I’m really looking forward to reading it. I hope there will be plans to publish it in hard copy form as I think not many doctors (certainly the ones I know) will be inclined to read an e-book, whereas if they have a hard copy they can dip into when necessary, they might actually be inclined to do so…

[BenLabrador]

When is it due to be published?

[arTistapple]

WOW! So much to love. Look forward to getting my teeth into it.

[juanitamc]

Can't wait! Thank you so much

[ZeilaJee]

Up-to-date information all in one place! THANK YOU.

[ZeilaJee]

…and if you can/have enough useful clinical material, please can you address NDTs and how to combine with conventionals successfully to get balances right? Thank you again

[diogenes Remembering in reply to ZeilaJee]

There will be comments in the book

[Cleobear]

Thank you Diogenes. I will definitely be reading this, just wish the Drs would be interested as they seem to know zilch about thyroid unless they or a family member are sufferers

[holyshedballs]

Sounds excellent. I'm very much looking forward to reading it.

[wellness1]

Issues and controversies in the treatment of hypothyroidism 108

Are you sure you only needed 2 pages for this chapter? All kidding aside, it looks sure to be an important work. Thanks in advance to you and your colleagues.

[marigold22]

Has your e-book been published yet? Very interested in the connection between mitochondria and thyroid

[RedApple Administrator in reply to marigold22]

marigold22, Unfortunately diogenes (aka John Midgley) is no longer with us so cannot reply to your question healthunlocked.com/thyroidu...