I thought it might be useful to give TUK readers the chapter headlines we will use in the upcoming eBook, giving an indication of the scope of it and the basic thrust .
Hypothyroidism - Reappraisal of Pathophysiology, Diagnosis and Treatment with Implications for a New Paradigm 1
Foreword 4
Hypothyroidism 6
Definition 6
Epidemiology 7
Etiology 7
Concept of relational stability 13
Thyroid physiology 17
Iodine metabolism 18
Transmembrane transport and intra-cellular effects 19
Mitochondria and T3 actions 22
Deiodinases 23
Hypothalamic-pituitary-thyroid regulation 26
Homeostasis and allostasis 27
The regulatory network of the hypothalamic-pituitary-thyroid axis 30
The functionality of the hypothalamic-pituitary-thyroid axis 34
FT3 homeostasis as a system goal 39
Clinical implications of a FT3-inclusive perspective 46
Memory effects and hysteresis 50
Mechanisms of heath and disease 52
Approach to the patient 64
Symptoms of hypothyroidism 64
History 66
Physical examination 67
Laboratory thyroid function tests 68
Ultrasonography of the thyroid 70
Thyroid scintigraphy 71
Fine needle aspiration 72
Cardiac tests 72
Quality of life assessment 72
Biochemical thyroid function testing 73
The new paradigm for thyroid function diagnosis and treatment; conceptual and technical barriers to consistent outcomes 73
Foreword 73
Thyroid hormone testing: where have we come from? 75
Thyroid Function Testing -where are we now? 78
Fallacies in opposing free thyroid hormone test validity 79
Recommendations for the future 80
Conclusion 82
Diagnosis of hypothyroidism 91
Diagnostic considerations 91
Diagnostic use of TSH 92
TSH reference range 93
Treatment of hypothyroidism 101
Treatment goals 103
Whom to treat 103
How to treat hypothyroidism 104
Treatment effects 107
Issues and controversies in the treatment of hypothyroidism 108
Treatment failure 110
Treatment monitoring 113
Treatment duration 113
Adverse effects 114
Treatment with alternative drugs 115
Nutrition and smoking 119
Special considerations in the treatment of hypothyroidism 122
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diogenes
Remembering
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Better warn the webmaster of the site that will be offering the download, that there could be mad rush from thousands of TUK forum members on release day! We don't want the site to crash due to sheer weight of traffic 🤣
🤣🤣 we should work out a system - if your handle starts with A-E, you can download on the day it's released. F-J, day 2, and so on ... Sorry RedApple you will be on Day 4 😂😜
Sounds really comprehensive. I'll be buying 2 copies I think, one for myself and one for my GP surgery! Thank you Diogenes, this book can't come fast enough for the healthcare profession.
Let's hope the NHS Endo Consultants read it ... maybe when they have the time on their strike...Oh sorry no they will be catching up on their private work and then going back to NHS for double - time overtime
Diogenes, thank you, thank you! You've obviously put a lot of work into this book. The only thyroid book I bought in the early days was by Joan Gomez "How to cope with thyroid problems". The intro stated that you would have to just take a tiny white tablet for the rest of your life, to be ok!! 🙈🙈 If only it were that simple. One thing she did say, which was interesting though and I think true about myself, is that people who usually suffer with thyroid problems tend to be warm, kind hearted people!
Wondering, how will you be spreading the word about your new eBook to the "medical profession?" Do you have a good feeling about your book educating our GPs? I do hope so! Thank you again.
Sorry and I don’t mean anything personal you could well be a warm, kind hearted person but I think Joan Gomez saying ‘ people who usually suffer with thyroid problems tend to be warm, kind hearted people!’ is as batty as her saying ‘that you would have to just take a tiny white tablet for the rest of your life, to be ok!! ’
Well spotted, I was misdiagnosed with post partum thyroiditis that was Hashi’s all along. I could have done with knowing more back then and GPs Endos etc knowing more. Mind you ‘puberty to conception through to menopause and your thyroid’ could be a another whole book 📚
Pregnancy will figure in the appropriate chapter on whom to treat. Preconception will stand as a description of "normal euthyroid" patients. Postpartum will also figure here.
Thank you so much for this! I’m really looking forward to reading it. I hope there will be plans to publish it in hard copy form as I think not many doctors (certainly the ones I know) will be inclined to read an e-book, whereas if they have a hard copy they can dip into when necessary, they might actually be inclined to do so…
…and if you can/have enough useful clinical material, please can you address NDTs and how to combine with conventionals successfully to get balances right? Thank you again
Thank you Diogenes. I will definitely be reading this, just wish the Drs would be interested as they seem to know zilch about thyroid unless they or a family member are sufferers
Issues and controversies in the treatment of hypothyroidism 108
Are you sure you only needed 2 pages for this chapter? All kidding aside, it looks sure to be an important work. Thanks in advance to you and your colleagues.
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All kidding aside, it looks sure to be an important work. Thanks in advance to you and your colleagues. 
Thyroid ebook on Kindle offer today 
Six Months later - upcoming meeting with my MD (input needed) 
