thyroxine drug interactions: hello, had a bad run... - Thyroid UK

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thyroxine drug interactions

haggisplant profile image
26 Replies

hello, had a bad run of viruses/ infections over the last 4 months. Including a chest infection and then covid.

Do various antibiotics interfere with thyroxine? I’m so brainfogged I can’t work out what google is saying.

Clarithomycin for tonsillitis last week - feel v v thyroidy this week. Can’t remember the ones I had for chest infection but that was 2 months ago.

I’ve also upped hrt 2 months ago - transdermal but I know it can sometimes still impact.

I’m seeing Gp next week for an irregular heartbeat at instruction of nurse who saw me with tonsillitis which I feel like could be a hypothyroid thing plus post covid. Just want to check re interactions before having any blood tests etc.

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haggisplant
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26 Replies
SeasideSusie profile image
SeasideSusieRemembering

Try this interaction checker

go.drugbank.com/drug-intera...

Lalatoot profile image
Lalatoot

Setting any possible drug and levo interactions aside. You have been poorly for quite a while with your body using its resources to fight those infections so it seems logical that your thyroid hormones would be depleted.Taking different medication and being ill can also affect gut function which in turn can affect absorption of oral thyroid hormones so there is the double whammy of getting less out of your dose.

haggisplant profile image
haggisplant in reply toLalatoot

yes - I could just be = offensive word removed by Admin = knackered 😂 can’t even blame low testosterone as I’m on that too!

Vdubbers profile image
Vdubbers

Hi. From a personal note whenever I have to take antibiotics I always use a probiotic. Antibiotics are known to kill the good gut bacteria. Hope this helps 🙏

haggisplant profile image
haggisplant

thanks all, I also think it’s likely the oestrogen may be starting to cause issues. I’m on over the licensed amount (with Gp approval)

I’ve also been taking ibu, paracetamol and cocodamol (spaced, within the limits) for over a week due to the pain so potentially also messed things up?

SeasideSusie profile image
SeasideSusieRemembering in reply tohaggisplant

haggisplant

Consider doing an iron panel when you have finished with co-codamol. The body turns the codeine into morphine and this can deplete iron levels. This happened to me after taking just a few co-codamol a few months ago and I needed to supplement with iron for a while. Medichecks Home Iron Test is the full iron panel.

haggisplant profile image
haggisplant in reply toSeasideSusie

I only took 2-4 tablets at night for about 4 nights

SeasideSusie profile image
SeasideSusieRemembering in reply tohaggisplant

About the same total amount I took over a few days, I might have taken even less, and I only ever took one at a time as they made my head a bit skewy, my iron and saturation plummeted. You might be fine but you could react like me, I'm just pointing out the possibility.

gabkad profile image
gabkad in reply tohaggisplant

Even though supposedly it's 'rare', ibuprofen gives me cardiac irregularity. It's symptomatic and decidedly unpleasant. I'd get two beats close together and then a long pause and again two beats. It took three days after stopping the ibuprofen for the heart beats to return to normal.

Covid can also affect the heart. I was so exhausted afterwards, I felt like I was dying. I'm okay since the end of January but was not at all well for seven weeks.

haggisplant profile image
haggisplant in reply togabkad

thanks, this started a month after covid and 2 weeks after a different infection.

Due to a previous chest infection I think I took the top Fostair amount for around 2 months too - no idea if that also could have been an issue. But haven’t for several weeks

I’ve been around far too many snotty kids this year!

haggisplant profile image
haggisplant

I’ve actually re started the x2 spatone with vit c today actually. Following covid and hrt increase Ive had bleeds every fortnight - I thought small but could have been enough to cause issues. I’ve also now realised I’ve too many boxes from Amazon repeat to have been taking any since Xmas! I was over 80 last test but that was 6 months ago

gabkad profile image
gabkad in reply tohaggisplant

Have you had an ultrasound done? I don't know if you are post meno or pre but endometrial

hyperplasia due to low progesterone can be a problem.

haggisplant profile image
haggisplant in reply togabkad

peri -no I haven’t but it’s normal to do so after changing hrt. I’m getting small periods again though I think despite continuous progesterone.

I’m starting to think feeling awful two days ago could have been pmt - I couldn’t think straight. I have a small period today

It’s the constipation that makes me wonder if I’m not on enough thyroxine though I know oestrogen can that too!

gabkad profile image
gabkad in reply tohaggisplant

I got endometrial hyperplasia with bleeding 10 years post menopause post Covid. Had an ultrasound done to diagnose it. I use 100 mg progesterone pellets/balls and the follow up ultrasound showed that the lining was down to 4 mm thickness and I've had no spotting since. So you may need to talk to the doctor. Covid is famous for doing all manner of nasty things to our hormones. Even if on continuous HRT. I had to increase the progesterone from whatever is in the cream to adding the progesterone balls (oral micronized).

haggisplant profile image
haggisplant in reply togabkad

thank you. I’m on x2 100 Utrogestan (body identical progesterone.) daily.

Shelleyblue profile image
Shelleyblue

Really sorry to hear you are feeling like this. Yes it drug interaction. So you are on HRT and it has been increased - which should have meant you have had another recent blood test to see if your thyroid levels are OK, however , not all blood tests show the same as symptoms so your GP should be guided by your symptoms, which means you should have had an increase in thyroid meds. The other thing is that COVID depletes your fT3 levels when poorly and it can take a long time to get those levels back up again , Do you convert T4 to T3 well ?? So really you should have had a complete thyroid panel done 6 months after covid. TSH fT3 and fT4 levels should have been checked. If your having bad palpitations or signs of AF then you really should have another thyroid panel done - because low levels of fT4 and fT3 can cause palpitations or AF in thyroid patients. The brain fog is possibly due to low thyroid levels too. Antibiotics can also reduce absorption of thyroid meds. Not a lot of GP's are aware of these problems for thyroid patients. If after all these tests the GP is reluctant to increase your meds then request a referral to an endocrinologist or a trial of adding T3 meds (liothyronine). Gp's are allowed to prescribe this but not sure if they have been told this yet by the ICB, so it's better if you request and urgent referral to an endocrinologist. If not then ask to be referred to a cardiologist and talk about having T3 to help you for a trial period . Please look at joining the ITT group or TTT group on Facebook. I wish you good health very soon . 🙏

SarahJane1471 profile image
SarahJane1471 in reply toShelleyblue

WHAT!!!!😳Is that correct? Can GPs prescribe T3 now without instruction from Endocrinologist?

JAmanda profile image
JAmanda

sorry no answers except am in a similar boat - got covid after not even a cold in the last 3 years and git prgressively ill over 7 weeks til hospitalised with acute asthma. Given tons of antibiotics and steroids and have been quite demented! The steroids decrease the thyroid meds absorption no? Now, how to juggle the omeprazole and fexofenadine with magnesium vit d, vit Bs, as well as lio and Levo? No idea really!

Hopefully I’ll be off the new stuff soon as will not see too big a drop on my thyroid levels but who knows.

TheAmaizing2023 profile image
TheAmaizing2023

I am so sorry to hear what you are dealing with! I can relate as I was hospitalised with horrible kidney infection in Jan this year and I am still on antibiotics and some procedures to treat it. Before that I had sinuses infection, flue and after the kidney infection got covid and sinuses again. My energy levels are very, very poor 😭 I even sleep through my levothyroxine alarms now 😱 I am taking very strong probiotic along all the supplements, but the cold intolerance, extreem exhausion and brain fog is just killing me right now. I called my GP and despite being on antibiotics for most of this year they asked to wait 3 more days to ensure that this is no a cold or viral infection... no blood forms authorised yet which is silly. I am trying to seek help privately. I hope things improve for you soon! I will try to drop in an update when I get my bloods done. Stay strong!

praxis profile image
praxis

I'm still recovering from 9 months of long covid. I found that covid itself was interfering significantly with my thyroxin levels and, to certain extent, also long covid although it is gradually improving.

haggisplant profile image
haggisplant in reply topraxis

sorry for the late reply. I’ve been knackered. In what way did it interfere?

FoggyThinker profile image
FoggyThinker

My guess (from what I've read) is that the illnesses and medicines also affect adrenal function which is closely related to thyroid activity... and to feeling knackered! Might be an angle to explore?

praxis profile image
praxis

Are you sure you don't have long covid? I've had really bad brain fog throughout the 9 months since it started. Here in Italy they have set up some clinics just to deal with long covid and they are saying that having Hashi or other thyroid problems is often worsened.

Mollyfan profile image
Mollyfan

This really resonates with me…. I also had a nasty bug in January and feel that my thyroid hormones have been all over the place since. I had a private ultrasound done which showed chronic thyroiditis/ subacute thyroiditis and assume that the bug triggered an autoimmune attack. Weirdly my resting pulse has been up and down from 63 to 80 and seems to be pulsatile. Has anyone studied the thyroid hormone release during and after an attack?

It would be wonderful if some enlightened endocrinologist was interested!

Anyone else had this or any suggestions?

Restingvpulse
haggisplant profile image
haggisplant

sorry for the delay in replying - I was struggling and had so much on!

Last week I started to feel so much better. Just in time for a really hectic few days at work. But wiped on the Friday. Which can happen if I’m on too much thyroxine as well as too little!

My thyroid test has come back 0.05 tsh and t4 23.7. This was 9:00 am morning and I hadn’t taken thyroxine that day .

The last time I may have taken biotin was the Monday, the test being at 9 am on the Friday.

Previous tests - only in jan- were 0.29 and t4 17. I’ve since started testosterone and upped oestrogen to 125, and taking utrogestan x200 per night orally (this can apparently improve t4 levels.)

Due to heart palpitations the Gp wants me to reduce to 100, currently 125 and retest in 3 months.

did I leave enough time off biotin before test? Bit worried about reducing so much but I feel I have to. To then argue to go back up to alternating days!

The iron is that I’m feeling less foggy headed now. Argh.

haggisplant profile image
haggisplant in reply tohaggisplant

might may a separate post

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