Who else takes combo T4/T3 just once a day?
I’ve recently had another blood test done these are the results .
21/2/23
150 Levo 15mcgs T3
Last dose 24hrs previous day
TSH <0.3 (0.35-4.94)
Ft4 16.8 (9-19)
Ft3 4.52 (2.6-5.7)
I take T4 and T3 once a day in the morning. There’s a 24hr gap from last dose to test
130396
The time gap of 24 hours was correct for Levo but for T3 you should have split your dose the day before the test into 2 or 3 and should have taken tbe last part 8-12 hours before the test. By leaving 24 hours you have a false low FT3 result .
How do you feel ?
I take Levo plus T3 and take them once a day except when testing and then I split my T3 into 2 doses the day before.
I can’t leave 8-12 hrs as if I take it past 1.30 I can’t get to sleep .
I was told a long while ago to add 20%?to the result if there’s a 24hr gap
The 20% is a guesstimate, there's no way of knowing it's accurate for an individual unless they've tested with the advised time gap and compared results.
130396,
The 20% ia a 'guessimate' based upon what was available then and if you read older posts on this forum you will see that was the suggested. However, the available calculation has since been abandoned as there are too many variables.
what does that mean ? The 20% has been abandoned?
Why is it a false low? If somebody doses only once a day then their ft3 will really be that low every day at that time under normal circumstances. What has been measured is the lowest that the ft3 gets on a once daily dose.
I suppose it all depends what you want to know... the highest perhaps for your own knowledge..... the lowest if the results are for Endo 😏
I want to know if I need a dose increase? I don’t have an Endo
I would think not with a reading like this 24 hours after T3... how is your heart rate, BP and temperature? They are a good guide
Why not just test 8-12 hours after dose as suggested to find your mid range?
well how do you feel?
As evidenced by the replies here, there is so much debate about the best time to test for an ‘accurate’ reflection. Taking bloods is just one of many ways to evaluate if you need a dose increase and helps provide different pieces of the puzzle. What is your temperature like? What are your current symptoms? What is your HR like?
I would not adjust my dosage based simply on the bloods, you could have excellent bloods and still feel poorly. I think the over reliance on bloods these days is detrimental to getting well in many cases. There are too many variables and once you add T3, getting an accurate reflection of what is going on at a cellular level is even trickier.
my symptoms:
Weight gain. Constipation . Thinned hair.
These could be to do with my age ? 70
Have you had your Vitamin B 12 , Folates , Vitamin D and Iron/Ferritin tested in the last six months ?Yes, these could be age , but also low B12 or Folates , or Vitamin B 12 or Folate deficiency are often more common in older people but seldom regularly tested for.
These issues can effect your thyroid function and how well you absorb your thyroid medication, other drugs , supplements and nutrients from food too .
They cause a lot of issues in themselves including Fatigue , Insomnia , Palpitations, Dizziness , Muscle weakness and problems with digestion , skin and hair.
It's worth requesting for these blood tests to be done as regularly as you are allowed , especially if you have thyroid issues , and collect the results just as you do for your thyroid panel , as if they are borderline low they will tell you it's normal , but what is normal in the range may not be normal for you and you may need to start B12 and Folate supplements, and extra Vitamin D to prevent them getting worse or to improve your overall symptoms.
If total B 12 results keep showing as normal but your symptoms are not improving you need to request an Active B12 test to make sure that proper B12 conversion is occurring.
I had very rapid weight gain in strange places , the muscles were weak and reducing in size on my arms and legs and my skin and hair were awful.
I had both Vitamin B12 deficiency anaemia and Vitamin D deficiency. Since starting injections for B 12 , and increasing folate and vitamin D supplements I've been able to control my symptoms better. I think it's worth ruling out anything else going on before changing the dose just in case there is a missing piece in the jigsaw that a thyroid drug modification alone won't change as much. Hope that is useful. Take care , Bee
yes I have all of these tested every 12 weeks by my haematologist. They are all optimal and I’m very careful to keep them that way . Have done this since 2014
hi lalatoot
That makes sense that it’s the lowest it will be if taken once a day. So theoretically it’s actually higher through the day than the results show? Perhaps that’s why I don’t feel the need to dose throughout the day!
Do you think the results are ok? Only asking as I have put weight on over last couple of years and my constipation is quite bad so need to take a laxative at night
Yes both ft4 and ft3 are at their lowest. So for most of the day your levels are higher. If you tested 2 to 4 hours after your doses then you would get ft4 and ft3 around their highest.
If you tested ft4 and ft3 around 12 hours after doses you'd get an average level .
If those were my results and I wanted to see if I could improve lingering symptoms I might consider testing after 12 hours to get an idea of average levels to see what leeway I had to change doses.
Or based on the lowest results I might consider reducing my levo slightly by 12.5 per day maybe and once levels had dropped, adding in another 5mcg t3. This would be to see if that different balance between t4 and t3 improved the lingering symptoms.
On combo it is trial and error as to the doses we need. When we are reasonably well we don't want to make big changes to spoil what we already have.
I would also add that after 18months on steady levo t3 doses I am still finding that symptoms are improving with no changes to my dose so it can be a very long term thing
thank you for your reply Lalatoot .
I can’t test 12 hrs after taking my morning doses as that would be 8pm and Drs are closed then.
So I really don’t know what to do!!!
I increased T4 about 6 months ago from 125 to 150 but kept the t3 the same dose. The results showed that both ft4 and ft3 had increased .
These were the results when on the lower t4 dose.
24/06/22 125mcgs Levo plus 15mcgs T3 test 8.25am last dose 24hrs Tsh <0.03(0.35-4.94)Ft4 12.5(9-19)35%Ft3 3.7(2.6-5.7)35.48%Add 20% 4.44 58.6%
"I can’t test 12 hrs after taking my morning doses as that would be 8pm and Drs are closed then."
8 -12 hrs is good enough for T3 , it doesn't have to be 12hrs .
(8 -12hrs is far enough away from the dose of T3/ T4 to miss the 'high peak' that happens when it is all absorbed into the blood all at once .. this high peak lasts from aprox 2 hrs after taking T4/T3 ~ to aprox 4-6hrs after taking them) .
So eg. you could take T3 at 7 /8am and test at 3 /4pm . This would show your mid/ average levels for that T3 dose pretty well ... however it's important to note that it would not show TSH at it's highest.. in late afternoon TSH would still be pretty close to it's lowest ... TSH is lowest between aprox 1-3pm each day ,then rises again to it's highest around midnight-2 am (aprox).
If the results are going to be seen by a GP you really don't want' to be showing a GP a lower TSH .. or else it is highly likely they will want to reduce your dose.... however in your case your TSH is already lower than they can measure.. their test machine can't measure anything less than 0.03 (hence the <) .. so if they are OK prescribing with your supressed TSH , it may not matter in this instance .
If results are 'just for you' , and you're not interested in getting the highest TSH, you can test at whatever time of day you want ... eg. you could get a private fingerprick test and test at 8 pm if you prefer.
Note ~ if you test Levo after 8 -12 hrs and you usually test after 24 , the result you get for fT4 will be slightly higher than you would usually get... but 8-12 hrs is still long enough to miss the high peak that happens between aprox 2-6 hrs after taking Levo .
These graphs show the effect of fT4 / fT3 levels at various time post dose .
Top Graph ~ Top Line shows fT3 level. (in people taking T3 + Levo)
Middle graph ~ Bottom Line shows fT4 level (in people taking T3 + Levo)
so basically ft3 is only high for a short time after it peaks then drops for the rest of the day? So it’s not running high all day?
I don’t ever feel it kick in or feel it dropping.
Is a finger prick test comparable to a venous blood test ? Asking as my friend is a phlebotomist and says they differ
What time the FT3 level is high in the blood is not an indication of what time it get's into your cells... it doesn't do anything in the blood .. it just goes round .. it only 'does something' once it gets inside a cell , once inside a cell, it makes that cell do 'whatever that cell does'.. (heart, brain etc )... the 'action' of T3 on that cell can last anything up to about 2 or even 3 days,( depending on all sorts of complexities)
So you can't look a those graphs as showing 'when you feel it '... they simply show when the level s are highest/ lowest as they are being carried around in the blood .
As for fingerprick vs venous ?.... it is not so much that which makes for all the variability we see in FT4 / fT3/TSH testing (although it may obviously have some impact .,,and some unforseen cock up's resulting in failed tests eg delay in sample arriving at the lab due to sitting in a hot post box during a strike in june etc.. or damaging the blood cells as they come out by squeezing the finger etc etc )
there are just as many differences in NHS venous tests when the samples are tested at different NHS labs , due to them all using different test platforms( machine) which use diff anaysis methods , made by diff manufacturers , and having diff [ref ranges] . The whole fT4 / fT3 / TSH system has a large ( and unacceptable) level of variation in results , but it's the best we've got at the moment (until the endocrinology profession pull their finger out and demand better/ closer comparability between diff test platforms/ labs ) .
So to get the best possible comparison between our own tests, we not only need to keep the variables of 'time of last dose' and 'time of day' under control ... we also need to use the same lab as far as possible.
I’ve been doing private finger prick tests on same day as NHS tests for a while. The ranges are different so they’re never the same result, but there’s a lot of similarity. Eg. If T3 is above range on one it usually is on the other.
I guess you need to work out what percentage each test is through the range, rather than look at the figure itself? Then compare percentages?.
Yes I agree with you Lala- it makes logical sense that if the take your dose at the same time once per day in the morning then the blood draw the following morning- if done consistently around the same time- will yield a consistent result of it being at lowest.
I take my NDT at 5.30 am and 11 am and don’t adjust It the day before a test. I consistently do/have tests done at 9 am which is 22 hrs after I take the second dose. I have no problems doing it this way. For me my blood work is a guide not gospel- and my dose in accordance with the alleviation of symptoms..
someone has just replied to me saying my ft3 after 25th is 62% so it high considering there was a 24hr gap!
So this has now really worried me Lalatoot
Don't worry. You just need to be logical and methodical and think about what you want to try. On combo it is all trial and error to see what suits.You can keep things as they are with your lowest ft4 at 78% and your lowest ft3 at 61%.
You could test at 4pm as tatty suggests to try to get more of an average idea of levels to see if that helps guide you
You could alter your current doses based on the results we have been discussing. As you don't want your lowest levels any higher I would suggest that your first step would be a reduction in levo dose. Wait 8 weeks then do bloods. See what your levels are and how you are symptom wise and decide what to do next.
It is not easy to decide what to do. It took me 2 years of slow methodical dose changes 1 thing at a time and then waiting 8 weeks and doing blood tests, till I found doses I wanted to stay on longer term.
I measure ft4 at its lowest and ft3 at its average level. My ft4 low is 50% and my ft3 average is 72%.
thank you Lalatoot
I ncreased my Levo to 150 as both ft4 and ft3 were on the low side after I started HRT.
These were my results after starting HRT so I decided to increase T4 and keep t3 the same.
As you can see , both ft4 and ft3 have increased since the increase
I’m going to need to do this soon but am on a tiny 5mcg dose of T3 and it’s a capsule. I already split T4 50 at night 75 morning.
Should I empty the capsule out and cut it with a credit card like a drug dealer….? Create myself 2 ‘lines’. 🤣 ( you can tell I’ve been thinking this through) I need the results to show low really, I have felt fab on it and it’s really settling nicely so I don’t want to change down or up.
Regenallotment I’m really happy to read you’re on T3. I remember you posting about long term depression/anxiety and suspecting a low T3 to be involved there. May I ask how you’re doing on it? X
this reply is nothing to do with me or my post.
Please post separately or DM the person
apologies.
Should you ever wish to discuss or celebrate the success of someone else on one of my posts, please feel free 😉
So from my point of view, my question is to do with your post, I share your experience and take my meds similarly to you, I have the same question. So by contributing and adding to the responses, I have helped push your message up the reading list of the forum, enabling you to get more responses, I find reading other’s responses helps us all learn. I apologise you feel this post is hijacked and will be careful in my responses in future.
Socialite or gangsters moll hmmm 🤔 or watching too many dodgy movies 😏
If you want it to read low then leave a good gap and split the capsule, you can just mix half with water... though snorting might be hilarious so be sure to film it for us 🤣
Plenty of air in the capsules and see through so quite easy to judge your split and put the cap back together 🤗
You can never have too low a reading for an Endo 🙄
this is not a reply to my question . My post has been hijacked
Feel free to ignore responses to others
your reply isn’t answering my post . Perhaps create your own postv
There is a complication if you take combination T4/T3 like NDT. If you do the test 24 hours ahead the T3 will be low, but if you do 12 hours ahead the T4 will be high and TSH too low. I tend to opt for 24 hours and acknowledge the T3 will be low, mainly so the GP doesn’t panic and I don’t have to get into a huge debate with them about why I don’t need to reduce my dose based on artificially high T4 and low TSH (if that makes sense…….)
TSH is not affected by 'time of last dose'.
And fT4 is 'not much affected' by the time you get past 8-12 hrs... it is most affected between 2-6hrs post dose .
See the graphs i posted in other reply on this post Buttercups ~they are showing levels on T3+Levo combo rather than NDT , so not direct comparison, but .. TSH is not affected by time of last dose because that level has already been set by the levels of T4/T3 during the previous few days /weeks . TSH doesn't change on a day to day basis as a result of time of dose , but it does change each day as a result of 'time of test' due to the circadian rhythm for TSH . higher middle of night ~ lowest mid afternoon
do you normally dose once a day like I do?
yes. I normally take it when I wake during the night (somewhere between 2-4am) so I can guarantee an empty stomach………😉
how long after you take your doses is your blood test?
I would take that day’s dose after testing so about 28 hours (a bit naughty really….)
what do your results look like after that gap?
Thanks for your replies - much appreciated
my TSH has been slightly suppressed. My T4 low (just now scrapped into bottom of range, was below) and my T3 is low. Hence why I don’t want to risk arguments about lowering dose as I have already had comments about needing to lower dose to get TSH in range, even with a T4 of 9 (reference range 12-22!!)
yes I understand what you mean
how long after last doses do you test??
these are my latest results leaving an 11hr gap from last dose of t4 abd t3
13/3/23 Monitor My Health 150mcs Levo plus 15mcgs T3Tested at 7pm 11 hrs after doseTsh <0.01 (0.27-4.2)Ft4 20.1 (12-22)Ft3 5.8 (3.1-6.8)
interesting. There are people on here much more experienced than me, but I’m wondering if you take them separately whether the best timings to test are 12 hours after T3 and 24 hours after T4. I wonder if that might raise your TSH and lower your T4……
As I say I’m not an expert and am only speculating if it would give a different perspective of your levels…..
when I’ve put my results here before after leaving a gap of 24hrs I was asked to test t3 after 12 hrs which is why these results are like this as the purpose was to see what T3 was like.
After 24hrs my ft4 is always around 14.1
5/9/22 150 Levo plus 15mcgs T3 last dose 8.20 previous day TSH <0.03 (0.35-4.94)Ft4 14.1 (9-19) 51%Ft3 4.3(2.6-5.7) 54.94%Add 20% = 5.16 82.58%100 Estradot patch 24211/11/22150 Levo 15mcgs T3Last dose 24hrs previous day Tsh <0.03 (0.35-4.94)Ft4 14.1 (9-19) 51%Ft3 4.3 (2.6-5.7) 54.94.%
That makes sense. It’s complicated isn’t it when you are trying to balance both the results 🤦♀️
Amazing the difference in T4
well I did what I was asked and tested for ft3 after 11 hrs just to see what it was instead of 24hrs
Yep, I take 100mcg T4 and 15mcg T3 when I wake up, I don't find the T3 as effective if I split it
I only split it the day before testing but it depends who the test is for...
I don’t split it now as I found I couldn’t get to sleep until 3/4am if I took it after 1.30pm
If you want to know for your own benefit you could do a home test 4hours after your morning dose and it would give you your highest levels which might be good to know? It's likely that your T3 is going to be quite a bit over range
being over range after taking T3 is normal though. I wanted to know really if I should increase T3
Not by mid dose you shouldn't possibly a little over if just one dose per day but that would peak around 4 hours after
what does “not by mid dose” mean ?
That you shouldn’t be over range by mid dose (half way between tablets) even if you went slightly over at the peak
so if I tested 12 hrs after my morning dose (as I take it just once a day at 8am) it’s shouldn’t be over range?
I don’t ever feel tired using it just once a day
It should give you a much better idea how your body deals with the one dose as you now know where you are after 24 hours.... I assume us one shot wonders naturally take longer to absorb as we don't feel a spike? If you are feeling well on your current dose I wouldn't rock the boat 🤗
The range is intended to cover all the ups and downs of cycling T3/T4 one would assume?
do you take yours just once a day? I can’t test 12 hrs after my morning dose as that would be 8pm and Drs are closed at that time
Ah sorry I thought you said you weren't under a doctor so using private testing, so could do an evening test and pop it in the fridge till posting the next day?
Some GP's do later sessions maybe worth an enquiry?
if I did a private test at 8pm it would be a finger prick test which from what I understand are not accurate or comparable to a venous blood test.
Is that correct?
I've always found them excellent and very similar to venous test... I think most of us here rely on them
Completely empathise. Just to comment I take mine once per day in the morning first thing. Ive been told the same by this forum re testing of ft 3 and ft 4. Sadly I'm on a ndt so it's just not possible without messing around with the ft4 result and my normal dosing regime. What do I do then.....well I stick to the 24hrs rule gap as that's what my endos who are ndt friendly have told me over the years! And in addition I check Temp/ pulse first thing before rising & look at signs & symptoms. Paul Robinsom has never found on his T3 only regime that dosing via the T3 result only to be very reliable. He & his GP found that if they were guided by Ft3 levels only they were constantly changing his up & down & he didnt feel well. This is because T3 in the body is naturally so variable and subject to a wide variety of factors unlike the ft4 level, which changes very slowly over a much longer period like weeks. Eg cold weather, level of activity, intensity of activity, food etc So you'd have to control all your environmental, personal, activity and emotional, stress levels as well
...as Ft3 level will be affected by all of these. Inaddition Ft3 has a natural cycle of level of Ft3 - ut naturally goes up and down in people who are not medicated, unlike ft4 which is far more stable Most of us who use a combination treatment do convert but not sufficient so a top up of some ft3 helps and who knows may aid better conversion..no one really knows. Precisely what you & I are doing with our meds
I'm inclined to agree with Paul Roninson re testing ft3. ....
At the end of the day it comes down to how you feel and whether you have any signs of over or under dosing......ultimately. I know forum members on here don't agree with me and therefore dont agree with Dr Skinner, Dr Peatfield and a well regarded nhs endo that I wont name as he still practises who ALL advised me on a 24hr gap before tresting. So until science moves on with it's rather crude blood tests I'm sticking with their advice.
I'm NOT saying however what you should do however.....just commenting on what I do and why & what I've been advised by professionals.
Good luck it's a conundrum!!
Great advice, presumably you are well within range after 24 hours even on NDT though it isn't really comparable with it giving a slower release of T3 ?
The thing is to understand the limitations of testing and just aim for continuity in your personal choice of regime whether it be 2-4 after, 8-12 or 24 hours and try to understand your own cycle.
I don't know about NDT but the advice on here seems to lean toward symptomatic monitoring rather than blood testing as it is a very different method from the separate pills and has other limitations 🤷♀️
Hi Eeyore......didn't know ndt gives a slower release of T3 than synthectic, thats really interesting.....can you tell me more? Maybe pm me or a separate post as per the posters request. Thanks 😊
wl,
It is thought that because NDT hormones are bound to thyroglobulin they are not available until digested. Hence why some say HRT offers a smoother ride.
HRT?
🤣. ....
Think I need mine as brain going askew!
Obviously meant to say 'Hence why some say NDT offers a smoother ride.'
🤣 Yes I defo found/find ndt gave/gives me a much smoother consistent ride....no ups or downs just level....like before I developed hypothyroidism. Hadn't thought if it is slow release.....interesting idea.
why HRT?
130396 ... 'HRT' was just a typo , Radd obviously meant to write NDT ( Natural Dessicated Thyroid . Waveylines was just pointing it out.
thanks for exposing that. I thought she meant hrt was a problem
Cos Radd wrote HRT....but meant to write NDT. 😊
I would like to know more about this too, can you pm me if you hear anything back please.
healthunlocked.com/thyroidu...
this is referring to ndt. I am on combo T4/t3
Yes, this was for Spangle15
why is this on my thread then
As your thread has stimulated discussions with others who are interested, as the original poster you receive all questions and answers though they aren't necessarily aimed directly at you 🤗
We all learn so much from this criss cross of information, sorry it can be a bit bewildering when your thread is popular
this is so annoying!!! I put in my question only people on t4/t3 to answer
How ungrateful! Strangers are going out of their way to try and help you and you're telling them all off!
I take T4/T3 once a day as well, and I was going to respond to your question until I saw your unkindness. 🤷🏻♀️
There are others on the board who are obviously much more generous of spirit than me who may be along to help you.
Best of luck, I hope you find your answer. 🍀
I wasn’t being ungrateful but so many of the replies have nothing to do with what I asked and I specifically asked for those on combo to reply.
If you’d like to reply I’d be very grateful
130396, This is a public forum, which means that anyone can comment on anything. We know it's frustrating to get replies that are not directly in answer to you, but this is the way of things on public discussions. As TiggerMe says, everyone can learn from things posted here.
If you don't want any more replies at all to your post, you can ask an admin to close it for you.
but I specifically as for only those on t3/t4 to answer.
Whenever you get a group of people in the same room, discussions almost always go off topic. This forum is no different. It's human nature. You can ignore replies that aren't relevant to your question.
And I am on t4/t3.....ndt has both
I've got to say if you meant synthetics only then it's best to say so. Might have been better to say those on levothyroxine & liothyronine. Then I wouldn't have responded because I would've known. Hope you get sorted.
Oh.... you'll get drummed out for calling them synthetics 🤣
Oooh noooo am scared.....but aren't they? Little seeds popped in the ground to grow & you pick what strength & type you fancy?? 🤣
waveylines, The problem with the word 'synthetics' is that people instinctively think of it negatively. Unlike 'natural desiccated thyroid' which is considered to be good because it is natural. The fact that both are highly processed in factories seems to escape people. There's probably very little that's 'natural' about desiccated thyroid by the time it's become pills in a pot on the pharmacy shelf.
Redapple whilst I acknowledge what you say to a point in the sense that all ndts have to meet the same variance of active ingredients as other drug/hormone requirement the Endocrine Website refers to ndt as 'natural' & liothyronine as 'synthectic.' endocrineweb.com/conditions...
And since we have been asked to discuss only levothyroxine & liothyromone maybe we might need a new thread to discuss this?
Have you been on the wine, you're all over the place with your words 😆? Perhaps we just need to agree that they all have excipients that need to be looked at perhaps more closely than the active ingredients...🤔
🤣😂😄 what me? Nooo never your honour! Sober as a judge.... (hic)
So if ndt T3 is slower to be taken up and slower to reach half life, doesn't that also mean the protocol for Liothyronine testing recommended on here would not work in the same way for ndt....due to the factors above. So that might be why my lovely clever docs just test 24hrs after not taking ndt as per levothyroxine? Makes sense!!
Silly me it's Wednesday you'll be on the cocktails🍹I didn't think they did recommend blood tests on NDT just symptoms, BP, RHR and pulse?
Your clever doc is probably just covering his 🐎(imagination required but it starts with A)
Ah yes that's is true but the GMC insisted so they gave them no choice or they shoot them.
Ooh yes cocktail time.....knew I missed something
More environmentally correct than the old burning at the stake... terrible waste of wood
DONE
I’ve done it now as didn’t know I had to be so specific
Did you mean "noted". Neither did I. 🤣😅😂 generally we are a bit more relaxed about it .....but I now see I wasn't what you wanted Good luck!
did you see my results for ft3 after 11hrs
Posted reply on your new thread
thank you. I’ll take a look
does splitting it make much difference to your results??
It's not really clear cut as splitting doses can increase absorption for some so there really are no hard and fast rules... I tend to split my dose for the benefit of the NHS (as they need to be the lowest so as not to risk a cut in prescription) leaving the 8 hour gap and for my own tests I don't to see where I peak as I test within 4 hours of last dose to give me a good overview.
So it is timing and dose/ splitting that effects the outcome and also the variables of different metabolisms etc....
Hi there 🙂I've been taking T3 and T4 once a day for 20+ years. I take 20mcg Liothyronine with 50mcg Thyroxine (I had it reduced from 75mcg last year and feel so much better for it). I also take Sertraline 50mg and swallow all three pills together whenever I remember - usually before noon. I've only had questionable results once, which is when my T4 was reduced from 75mcg to 50mcg. Hope this is useful. x
thank you debt3 .
How long do you leave after you last dose to blood test? What do your results look like?
Why did you reduce T4?
debt3 did you see my answer to youb?
Hello again! I'm quite lax with my blood tests. I should have had my last one done about 4 months ago, but because I'm feeling so well I've been procrastinating. GP send me reminders so I might pop along to the phleb clinic tomorrow while it's fresh in my mind. I started on the lower dose in August last year because the GP said my T4 was "modestly over-replaced" and we need to avoid suppression of TSH. My Serum TSH level was 0.05 mu/L which is below the low reference limit. He had suggested I come off the Liothyronine (imagine my reaction to this sanity saver!), so he then opted to reduce the thyroxine instead. It certainly has given me a whole new look at life, although I have to admit to feeling cold as opposed to the unnerving hot flushes every day. x
thank you for your reply. Do you know what your results were before you reduced your dose? Abd do you know how big the gap is from coding to blood test?
Thank you for your replies
I take 100mcg levothyroxine and 25mcg liothyronine as a one off dose early in the morning with water nothing else for an hour. I have twice in the last 3 years taken 2 blood tests three days apart, the first splitting my dose of liothyronine as suggested and then blood test approx 12 hours post t3 and 24 post t4. I then 48 hours later repeated the blood test 24 hours after taking both drugs. On the first occasion the ft3 was 16% higher on the first blood test from the second and on the second time of dual blood tests ft3 was 18% higher on the first blood test. I haven’t found any difference in how I feel if I split the dose of liothyronine so I continue to take both together which seems to work for me.
I don’t plan to routinely take 2 blood tests but it was curiosity to see the difference. I now plan just to test privately once a year six months after my ‘yearly’ nhs blood test. I would of course check bloods if I felt less well.
Hope that helps
thank you for your reply
Did you see my results?
I’m wondering what they look like with someone who also takes their doses once a day?
Maybe you could take a look for me… I’ll post them here for you do it’s easier
21/2/23150 Levo 15mcgs T3Last dose 24hrs previous day TSH <0.3 (0.35-4.94)Ft4 16.8 (9-19)Ft3 4.52 (2.6-5.7)
Looking at your results your ft3 is approx 62% of the range which is quite high for 24 hours post dose. If however you feel well with no adverse effects I would be happy. Ft4 is in range and TSH only slightly suppressed. As I’m sure others have said blood tests are only a small part of the jigsaw. It is definitely worth checking vitamins as well and supplementing if necessary.
I wish you good health
I don’t feel unwell . I have a knotted tummy feeling . I also have constipation and weight gain .
You say it’s quite high for 24 hrs does that mean I’m taking too much.
Please remember we are not health professionals only fellow hypothyroid sufferers. Normal signs of over replacement with liothyronine would normally include some or all of the following, raised pulse rate, feelings of restlessness and or anxiety, loose stool. It may be that whatever is happening to you may not be connected to your thyroid replacement hormones. If you have had a change in bowel habits I would urge you to talk to your gp. Good luck.
Advice needed please -When do I have blood test on T3 and would a small amount of T4 have affected TSH.
Can I decide whether to go up on meds with only a TSH reading (GP won't do T4, T3)?
Endo. advice and thyroid results advice please
Can anyone offer feedback on how they changed from NDT. to levothyroxine only, or to a combination of levo. and T3.
odd new results on combination 
