TGAB 765 IU/ml - everything else normal? - Thyroid UK

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TGAB 765 IU/ml - everything else normal?

Tulah91 profile image
12 Replies

Hi all,

To give a bit of background, most women in my family have under active thyroids, and my sister has Hashimotos. I’ve had quite a lot of symptom for a number of years (tiredness, pain/sensitivity to cold in hands, eyebrows falling out etc).

I have been to the doctors about it twice and had blood tests, to be told everything looked normal. I have since gone to a private company and sent off my blood sample to them to test. My readings came back as below.

Total Thyroxine (T4): 94 (normal range is 59-154 nmol/L)

Thyroid Stimulating Hormone (TSH): 2.63 (normal range is 0.27-4.2 mIU/L)

Free Thyroxine (FT4): 14.2 (normal range is 12-22 pmol/l)

Free T3 (FT3): 5.1 (normal range is 3.1-6.8 pmol/l)

Anti-Thyroid Peroxidase Antibodies (TPEX): 11.2 (normal range is 0-34 IU/ml)

Thyroglobulin Antibody (TGAB): 765 (high, normal range is 0-115 IU/ml)

As you can see, all my readings are within normal ranges apart from TGAB which is showing as significantly high. Has anyone had this where this in isolation has been high? What does this mean please?

I am suspecting it means that my thyroid could become an issue in the future but isn’t yet (as all my other readings seem ok). I am going to take my results to the doctors, so if anyone knows of any other tests I should maybe push for given my results, please let me know. Due to all my other results being normal, I feel that I may just be ignored again even though I feel as though I have had symptoms for years.

TIA xx 🥰 (now added normal ranges in)

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12 Replies
Jaydee1507 profile image
Jaydee1507Administrator

What time of day did you have the blood test? TSH varies throughout the day and is at it's highest (best time to test) at 9am.

You are right that the positive antibodies indicate an issue with your thyroid but your thyroid bloods aren't yet showing that you would be able to get a diagnosis and treatment yet.

Tulah91 profile image
Tulah91 in reply to Jaydee1507

Hi Jaydee,

I took the test between 9/10am so sounds like that was a good time to take it.

If the above is true about diagnosis and treatment, is it just a waiting game and a matter of checking my bloods to see when my other levels do start to deteriorate? And nothing I can do while waiting?

Thanks

in reply to Tulah91

Hi Tulah, From those results it looks like your thyroid is already failing.

Your TSH is suggesting something is amuck and your T4 is really low in range.

The body protects T3 so it will be working really hard to keep it at that high level.

You will likely find that your TSH keeps creeping up trying to encourage T4 production... Which will likely keep falling which in turn will see your T3 drop.

NHS won't treat until your TSH is at least above the range but more likely they want it nearer 10.

My best advice is to read this forum, learn all you can and advocate for yourself.

In terms of being proactive, diet is the main thing to look at. And stress! Hashis is worsened with stress so it's ideal if you can manage that.

Tulah91 profile image
Tulah91 in reply to

Thanks Witchinghour, your response is really informative. Confirms the thought of treatment not being available yet, but will see the doctor and push on the fact that quite clearly something isn’t right given my TGAB levels and my symptoms. Will also try and find some self remedies and tips on this forum, and will monitor bloods on a regular basis. Thanks x

Regenallotment profile image
Regenallotment in reply to

Depends on the GP, I was treated after 2 TSH readings over 4.8. Would be worth checking vitamins B12, D, Folate and Ferritin. You can make yourself feel loads better by optimising those. Also reading up on Izabella Wentz, considering diet changes (low sugar and higher fat, stopping dairy gluten, soy etc. and upping phytoestrogens like linseed or nuts. that will improve your energy and sleep etc.

Tulah91 profile image
Tulah91 in reply to Regenallotment

thanks, going to have a read over the Christmas period!

in reply to Tulah91

As you can see, all my readings are within normal ranges apart from TGAB which is showing as significantly high. Has anyone had this where this in isolation has been high? What does this mean please?

Normal isn't a result. It's an opinion and it's obviously not normal for you as you're symptomatic.

Your TGAb result isn't in isolation. TSH in a healthy person is rarely higher than 1.

Your TGAb confirms your thyroid issue is Autoimmune.

Hedgeree profile image
Hedgeree

Hi Tulah91 welcome to the forum 😊

If you can add the ranges to the rest of your results it would help others to be able to comment on them for you.

Best wishes.

Tulah91 profile image
Tulah91 in reply to Hedgeree

Hi Hedgeree, thanks for the advice, I have now added these in 🙂

"You must never use or accept the word normal from your doctor, yourself, or anyone else. I mean, what does normal actually mean? Normal for who? At what age? and in what circumstance? This term must disappear from your lexicon and it should disappear from the entire medical lexicon." Dr Robert Lustig

SlowDragon profile image
SlowDragonAdministrator

Essential to test vitamin D, folate, ferritin and B12 at least annually too

Low vitamin levels extremely common with autoimmune thyroid disease

low vitamin levels tend to lower TSH

Are you currently taking any vitamin supplements?

Do you have any gut issues

Have you had coeliac blood test done

pubmed.ncbi.nlm.nih.gov/303...

Based on these results, we recommend screening for TgAb antibodies in HT patients with symptom burden

Currently NHS reluctant to diagnose autoimmune thyroid disease based on only high TG antibodies

Email Thyroid U.K. for list of thyroid specialist endocrinologists and doctors

tukadmin@thyroiduk.org

Tulah91 profile image
Tulah91 in reply to SlowDragon

No I am not taking anything and have not had them tested, so it is definitely something I will look in to, thanks!

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