Selenium and zinc/ effects on thyroid function

[diogenes]

This recent paper shows how selenium and zinc affect thyroid parameters in pregnant women

Assessment of Joint Impact of Iodine, Selenium, and Zinc Status on Women's Third-Trimester Plasma Thyroid Hormone Levels 

  April 2022 Journal of Nutrition 152(7)         DOI: 10.1093/jn/nxac081         

 Klara Gustin , Marie Vahter, Malin Linnea Barman,  Maria Kippler et al   

Abstract

Background Iodine is essential for synthesizing thyroid hormones, but other micronutrients are also required for optimal thyroid function. However, there is a lack of data on combined micronutrient status in relation to thyroid hormones in pregnancy. Objective To assess the joint associations of iodine, selenium, and zinc status on plasma concentrations of thyroid hormones and thyroid stimulating hormone (TSH) in pregnancy. Methods We included 531 pregnant women (aged 22-40) participating in a Swedish birth-cohort who provided blood and spot urine samples in gestational week 27-33 (mean 29). Associations of urinary iodine (UIC), plasma selenium, and plasma zinc (measured by inductively coupled plasma mass spectrometry) with plasma hormone concentrations [total and free thyroxine (tT4, fT4), total and free triiodothyronine (tT3, fT3), and TSH] were explored with Bayesian kernel machine regression (BKMR; n = 516; outliers excluded) and multivariable-adjusted linear regression (n = 531; splined for non-linear associations) Results Median (IQR) micronutrient concentrations were 112 (80-156) µg/L for UIC, 67 (58-76) µg/L for plasma selenium, and 973 (842-1127) µg/L for plasma zinc; the former two median values being below recommended levels (150 µg/L and 70 µg/L, respectively). Mean±SD for TSH was 1.7±0.87 mIU/L, with 98% below 4 mIU/L. BKMR showed a positive trend of joint micronutrient concentrations with TSH. Plasma zinc was most influential for all hormones but tT3, for which plasma selenium was most influential. In adjusted linear regression models, zinc was positively associated with tT4, tT3, and TSH, and below 1200 µg/L also with fT4 and fT3. Selenium was inversely associated with fT3, and below 85 µg/L with tT3. Conclusions Pregnant women's plasma TSH concentrations in early third trimester increased with increasing joint status of iodine, selenium, and zinc. Zinc and selenium were more influential than iodine for the hormone concentrations. Multiple micronutrients need consideration in future studies of thyroid hormone status. 

[thyr01d]

That is very, very interesting thank-you Diogenes

[thyr01d]

Please, can anyone recommend a selenium supplement that does not cause the breath/body to smell? Vegan too please?

[diogenes Remembering in reply to thyr01d]

It only gives a body smell if you are taking too much.

[arTistapple in reply to diogenes]

Good info. A clue to odour?

[diogenes Remembering in reply to arTistapple]

Like a goat!

[arTistapple in reply to diogenes]

Oooh! Thank you.

[Geography1 in reply to thyr01d]

global healing selenium, made from mustard seeds. I bought it, but have not taken it. I guess mustard is high on selenium.

[helvella Administrator Thyroid UK in reply to Geography1]

They claim 200 micrograms of selenium. Which is more than I would take.

The paper below explains that they produce selenium-rich mustard seeds by growing on seleniferous soils.

Bioaccessible selenium sourced from Se-rich mustard cake facilitates protection from TBHP induced cytotoxicity in melanoma cells

ncbi.nlm.nih.gov/pmc/articl...

[Geography1 in reply to helvella]

Thank you, I will have a read, and I have not taken it because Most supplements just make me sick, so aim scaredbof thi one, plus it’s capsules and I am not good with big pills, they get stuck in my throat.

[thyr01d in reply to Geography1]

Oh thank-you Geography1, I absolutely love mustard, no doubt this is why.

[tattybogle]

Link to full text :

ncbi.nlm.nih.gov/pmc/articl...

[tattybogle in reply to tattybogle]

seems very interesting ... can't make much sense of it yet... will try again another day.