Has anyone taken Novothyral??: I’ve just come to... - Thyroid UK

Thyroid UK

140,948 members166,084 posts

Has anyone taken Novothyral??

Angie10116 profile image
18 Replies

I’ve just come to Poland for a couple of days and I went to see a thyroid specialist because my endocrinologist in the UK literally let me change my daughters on my own and does not control me.

I’ve just come to Poland for a couple of days and I went to see a thyroid specialist because my endocrinologist in the UK literally let me change my doses on my own and does not control me.

This new doctor gave me the above meds… at a dose of 100 mg of T4 and 20 mg of T3. I’m currently taking 75 mg of T4 (levothyroxine).

I don’t know whether to trust his doctor, because he said that anxiety and depression is all psychological and has nothing to do with thyroid hormones.

I’m sure that we all know that this is not true, hence why I’m not sure if I should trust him and start this medication.

Written by
Angie10116 profile image
Angie10116
To view profiles and participate in discussions please or .
Read more about...
18 Replies

I have a colleague on Novothyral. It´s a good drug if you need it, ie have low FT3 levels due to impaired T4 to T3 conversion. It contains T3 and T4 in a fixed ratio which may or may not be ideal for you.

Anxiety and depression are both common in hypothyroid patients (hypothyroid = suboptimal FT3 levels). The fact that your doctor claims it isn´t shows he is not very knowledgeable to use an understatement!

Angie10116 profile image
Angie10116 in reply to

I know! I felt so undermined and annoyed when he said that! I think my t3 is fine. He is trying to lower my tsh. I’ve put on 10kg in the last month or so and it’s been a yo-yo. I’ve been on t3 and separate T4 before and my anxiety got worse.

in reply toAngie10116

Why lower your TSH? Normally, you would would work on optimising the free Ts, especially free T3, and when that happens the TSH usually drops. But lowering the TSH sounds like a strange goal in itself because the TSH does not do much once on thyroid hormone replacement. It´s low free T3 that causes hypo symptoms such as weight gain. I had a below-range TSH on levo only along with low FT3 and had a lot of hypo symptoms that kept getting worse.

Angie10116 profile image
Angie10116 in reply to

My T4 and t3 are in range whilst tsh is 16.

in reply toAngie10116

Is that really 16 or 1.6???? Because a TSH of 16 means seriously under medicated if on any kind of thyroid hormone replacement, and full-blown hypothyroidism if not on thyroid hormone replacement!

Angie10116 profile image
Angie10116 in reply to

I mean 16.

My last results were:

02/02/2022

T4-18.5

TSH-16.79

T3-4.1

in reply toAngie10116

We´d need reference ranges with those results as they vary from lab to lab, but your free T3 seems low which would mean inadequate T4 to T3 conversion. How much thyroid hormone do you currently take? Or did you decide to stop levo as previously mentioned? What did your lab results look like before you were prescribed levo?

Angie10116 profile image
Angie10116 in reply to

I’m on 75mg currently. They are average ranges. I don’t have them rn but I know it’s all in range

in reply toAngie10116

Unfortunately, in range does not mean much as most doctors tend to think that anywhere in range is fine.

greygoose profile image
greygoose in reply toAngie10116

Just being in-range doesn't mean that the results are right for you. The ranges are usually too wide. But, we do need the ranges to understand the results. There's no such thing as 'average ranges' because ranges vary from lab to lab, so we need the ranges that came with your results.

Your FT4 looks as if it could be high, and your FT3 low in comparison, which would mean a conversion problem, and a need for T3. But, that TSH is totally out of sync with the Free results. Is the TSH result of over 16 a one-off? Or is it always that high? It could be that there has been interferrence in the testing. It does happen.

For you to be able to tolerate T3, all your nutrients need to be optimal - not just 'in-range'. Do you have results and ranges for vit D, vit B12, folate and ferritin? Often when people have problems taking T3 it's because they have one or more nutritional deficiencies.

So, suddenly taking 20 mcg T3, as in 1 tablet of Novothyral could be totally the wrong thing for you. It is normally suggested that one start on 5 mcg T3 for two weeks, and then increase by 5 mcg every two weeks until feeling well - increasing more slowly if necessary. Starting on 20 mcg would be a shock to the system - especially as you'd be increasing your T4 at the same time. And, cutting those tablets is not recommended. Although, at a pinch, you could do that. Alternatively, you could try the solution suggested by diogenes in this thread:

healthunlocked.com/thyroidu...

So, I think your suspicions about that endo are right. He doesn't really know what he's doing. He doesn't understand the finer points of treating hypothyroidism. :)

pennyannie profile image
pennyannie

Hello Angie :

I read that many people do well on Novothyral which I doubt is even considered as a treatment option in the UK.

The medication you have been prescribed is with a fixed ratio of 1/5 T3 to T4 :

i believe Novothyral also offer an alternative with a fixed ratio of1/4 ratio T3 /T4 :

Some of us take T3 and T4 independently to find our unique T3/T4 ratio :

Most people seem to feel at their best when their T3/T4 conversion ratio comes in at around 4 - so if you have a conversion issue it's likely better than just T4 monotherapy.

I think this new thyroid hormone replacement dose is much higher than you are currently are and without seeing some current T3 and T4 levels it's difficult to say much.

Your current dose of 75mcg T4 will take around 6-8 weeks to leave your body as T4 is a storage hormone and this new medication is higher at 100 mcg + 20 T3 - which is the active hormone and if you have never taken T3 before I would suggest you go slow and cut down these tablets into 1/4s to start off with .

Angie10116 profile image
Angie10116 in reply topennyannie

Hi thank you so much! I’ve taken t3 before but it just made my anxiety worse. Ugh it’s all so complicated.

pennyannie profile image
pennyannie in reply toAngie10116

Well, yes, balancing T3 and T4 independently can be challenging and takes time and patience.

How are your ferritin, folate, B12 and vitamin D levels as these need to be maintained at optimal levels to support your body and assist in the conversion of T4 into T3 ?

Angie10116 profile image
Angie10116 in reply topennyannie

They are okay thank you! All in upper range

SlowDragon profile image
SlowDragonAdministrator

That’s a huge jump up from just 75mcg levothyroxine

Thought you were also starting on T3 at 5mcg recently in a previous post ?

Which brand of levothyroxine are you currently taking

When were vitamin D, folate, ferritin and B12 last tested

If you do find you do well on Novathyal……you would need to think about how you get ongoing prescription

Angie10116 profile image
Angie10116 in reply toSlowDragon

I’m on accord.

I’ve been off of t3 for over 2 months as my anxiety and derealization got worse when I was on it.

My vitamins were tested 2 months ago and at fine thank you.

SlowDragon profile image
SlowDragonAdministrator in reply toAngie10116

Did you only try adding 5mcg T3

Typically dose is increased to 3 x 5mcg spread through the day….and retest after 6-8 weeks

If you’re going to try novathyal, suggest you wait until you get back home

Angie10116 profile image
Angie10116 in reply toSlowDragon

I took 5mg twice a day and it wasn’t great for me. But yes, I will do so when I get back

Not what you're looking for?

You may also like...

Need help with labs, figuring out dosaging from here

it won’t let me attach multiple photos. :/ My TSH went from 1.7 last month to 3.89 this month T3...

Novothyral

was speaking with a vet this afternoon as I had to take my bunny in. She is Polish and has...
Jefner profile image

Has anyone else had issues with their eyes and has Hashimoto’s?

A Few months ago I woke up & both my eyes were swollen. They’d been watering for weeks previously....
ajb1969 profile image

TSH of 27 (has anyone seen results this high)

Sept 2016 TSH was 1.7 Sept 2016 T4 was 13 13 Feb 2017 TSH 27 (0.30 - 5.50) 13 Feb 2017 T4 8...
LaLuna profile image

Can anyone help?

My daughter has been ill for nearly 3 months with fatigue, sleeping a lot of the time at first but...
appalachian49 profile image

Moderation team

See all
PurpleNails profile image
PurpleNailsAdministrator
helvella profile image
helvellaAdministrator
SlowDragon profile image
SlowDragonAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.