20-hydroxyeicosatetraenoic acid and thyroid dieases

[RABIDFOX]

Hello there,

I have been doing research recently and i came across something that may interest some of you. So i read the following study

jstage.jst.go.jp/article/tj...

To summarise it basically says aspirin helps with thyroid hormone conversion. So what does aspirin do?

Aspirin helps with headaches by blocking COX 1 and 2 which prevents prostaglandins being created from the release of lipase. so perhaps this is what contributes to some thyroid symptoms.

now i hypothesised that omega 6 is at fault as theres a few short-term studies with omega 3 showing a similar pattern (insignificant increases).

I read the following study pubmed.ncbi.nlm.nih.gov/258...

which talks about the 20-hydroxyeicosatetraenoic acid(20-HETE) and suggests it could contribute to hypertension in particular with hyperthyroid patients.

now what happens when we eat linoleic acid is its converted into arachidonic acid by D5D and D6D. This is later metabolised by cytochrome p450. A metabolite produced is this acid 20-HETE. It positively correlated with thyroid hormone levels as stated in the previous study. Furthermore, there's a lignan in sesame which has been used to treat thyroid cancer shown here link.springer.com/article/1...

this just happens to be an inhibitor of the 20-HETE so it ties in nicely with the theory but doesnt necessarily prove it the below study shows TSH reduced and T4 increases with lignans, they didn't measure T3 but I suspect it has increased also

so perhaps this could help in part with thyroid diseases ? let me know your thoughts if you have anything to add.

[diogenes Remembering]

There is a good reason why aspirin taken continuously alters the T4/T3 ratio. Firstly, these authors only measured total T4 and T3 (an old paper before FT4 and FT3 tests had been invented). Aspirin can displace T4 (and T3) from the transport proteins that take these hormones round the bloodstream and release as FT4 and FT3 to the appropriate tissue.. T4 being about 50 times the amount of T3 on these proteins is the most affected by aspirin. So, if the body wants to produce T3 from T4 in this condition, one needs a smaller amount of T4 on the proteins to produce the same amount of T3. Thus the T4/T3 ratio is less. In effect the aspirin has weakened the T4 attachment to the proteins more than T3. Also the fatty acids mentioned have the same effect. So FT4 and FT3 changes may not be mirrored by different bound T4 and T3 levels.

[RABIDFOX in reply to diogenes]

thankyou for your response