CBD oil

[Margaret]

My daughter in law suggested I try some CBD oil that might help me sleep so in my ignorance I thought I would give it a go. I take levothyroxine and liothyronine also I am on taking setraline because my husband passed away 5 years ago and I felt very depressed. With this medication I was going along very nicely but since trying the CBD oil I have taken a massive drop not feeling well and also very depressed. Does anyone know if the CBD oil could do this and how long it may take me to pick back up.

[Lalatoot]

Just from a swift glance on the internet there seems to be some possible interaction between CBD and setraline. prescriptionhope.com/blog-c... article suggests that CBD might worsen the side effects of setraline and might concentrate setraline in the body . The action Setraline is known to affect levo uptake and some folks need a slightly higher levo dose as a result. So maybe it is a knock on effect of CBD affecting setraline which in turn has affected levo and lio.

Hope you get on the mend soon and that the effects are short-lived.

[Margaret in reply to Lalatoot]

Thank you I think I should have read that before using it.

[Lalatoot in reply to Margaret]

Well we all have done similar so don't dwell on it. Just try to look after you until things settle.

[shaws Administrator]

First of all, I am very sorry your husband has died and that in itself can cause us to take a number of years just to come to terms with his demise.

Don't to worry about what you've taken - most of us have done that at one time or another.

The following is about CBD oil and usually we do try things we think might help us feel less symptomatic

healthline.com/nutrition/cb...

The fact that you're also taking medication due to your bereavement I hope it has been able to be of assistance to you.

Take thyroid hormones well apart from other medications as you don't want it to be interfered due to taking 'other' medication.

[Margaret in reply to shaws]

Thank you lesson learned

[shaws Administrator in reply to Margaret]

😊

[radd]

Margaret,

Oh, that awful for you. I hope the unwanted effects wear off quickly 😊.

[ZeilaJee]

Don't know if it helps - I found CBD oil made me feel very odd when I put it under my tongue as recommended. When I'm having chronic sleep difficulties, I rub in 4 drops only onto the fatty skin of my upper arms or thighs, then read for 20 minutes. By then my body seems to relax just that little bit to enable sleep, usually, to come.

[CG12345]

Valerian is meant to be helpful for sleep. Not sure about drugs interactions though so you would need to look into that

[CaptainBeOS]

That sounds familiar.

I tried CBD alongside Levo for one day day about a year ago. It made me feel like I was having the most severe hypo episode ever. It was during the time I was on T4 mono therapy, which I was not responding well to anyway: I was on a deliberately low dose of T4 to prevent horrid side effects like heart palpitations, insomnia, muscle cramps, extreme fatigue, mood problems. I was also taking Allopurinol at the time, which I subsequently learned suppresses TH levels and causes hypo like side effects. So in all likelihood the CDB just deepened an existing problem. You say you were doing well, certainly better than now, but the disturbed sleep suggests an existing problem you were trying to solve.

My experience of CBD certainly prompted me to try increasing my T4 dose again shortly after. Whether that was because of a lasting effect I cannot remember. The T4 increase didn't work out, as predicted. In turn that led me to switch to NDT / combination therapy, which is much better. I also ditched the Allopurinol.

If you are considering tweaking your TH medication, check all your TH levels first. If lalaloot is right, then your TH levels will have changed.

After much experimentation on myself this last year I have found that an increase in fT4 causes the onset of hypo like symptoms as strongly as a drop in fT3. So do consider that the change may in fT4 may be up instead of down. I've seen another person experience this on this forum just this week and the general advice from responders was to shift the balance in favour of the T3.

Also consider that this may also be a seasonal change that the CBD has just lifted the lid on and it will all settle down in the spring.

Regarding your combination therapy: My NHS endo is supper tight fisted with my T3 it and won't prescribe more than 10mcg/day, which means oral T4:T3 ratio of 10:1 when targeting a "normal" TSH of 2.0 - 3.0. This is borderline tolerable for me, I do not feel well on it, but I can live with it. But... I'm a thyroid cancer survivor and the goal is a TSH of <1, so with the cap on the T3 that T4:T3 ratio becomes 12.5:1, which I can't tolerate at all. It's as bad as monotherapy. My sleep is at its best on lower ratios, like those achieved with NDT (4:1). Sadly that is not available on the NHS and is expensive. So it's an ongoing fight to get my NHS endo to get off his high horse.

Anyway, the point is if you are lucky enough to get the T3 on the NHS, then you might not be getting an optimal ratio, hence the sleep problem and the feeling depressed.

Hope this helps.

[Margaret in reply to CaptainBeOS]

Thank you for this I am lucky that I am prescribed T3 by my gp I did wonder about adding a 10 mg at lunch time as I use to take this in addition to the levothyroxine 50 mg and 20 mg liothyronine that I take first thing in the morning. I stopped taking the extra 10 as I felt I didn’t need it. I am also lucky my gp also let’s me do my own medication as my results always come back that I am over medicated which I know myself I am not. I had this problem right from the start as it took months of being unwell before I got diagnosed with under active thyroid as I kept being told that I was within the normal range, in the end I went to see Dr Skinner (who unfortunately died) he more or less took one look at me and send definitely I had an under active thyroid within 2 weeks of being put on medication I started to feel better. I don’t convert properly from T4 to T3 so obviously that is why I have the T3. A little bit of my history. Stay well