Would you increase your dose if you were me? UP... - Thyroid UK

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Would you increase your dose if you were me? UPDATED.

Meanbeannyc profile image
78 Replies

I can’t figure out what to do. Still not feeling right. 112 Synthroid.

Why do I feel so bad with these levels?

112 Synthroid.

FT4: 1.4 (0.8-1.8)

FT3: 2.8 (2.3-4.2)

TT3: 82 (76-181)

TSH: 0.23 (0.27-4.6)

Same lab

FT4: 1.4 (0.8-1.8)

FT3: 3 (2.3-4.2)

TT3: 86 (76-181)

TSH: 1.2

Same lab again

FT4: 1.4 (0.8-1.8)

FT3: 2.8 (2.3-4.2)

TT3: 82 (76-181)

TSH: 0.34 (0.27-4.6)

Then at another lab:

FT4: 2 (0.9-1.8)

FT3: 2.78 (1.8-4.6)

TSH: 0.57 (0.27-4.6)

Then another lab

FT4: 1.76 (0.7-2.19)

FT3: 2.56 (2.77-5.27)

TSH: 0.47

Original lab:

FT4: 1.5 (0.8-1.8)

FT3: 2.7 (2.3-4.2)

T3: 89 (76-181)

TSH: 0.73 (0.27-4.6)

Original lab

FT4: 1.4 (0.8-1.8)

FT3: 2.6 (2.3-4.2)

TT3: 116 (76-181)

TSH: 0.66

FT4: 1.4 (0.8-1.8)

FT3: 2.6 (2.3-4.2)

TSH: 1.59

Another lab: 112/5 T3.

FT4: 1.37 (0.76-141)

FT3: 2.11 (2.18-4)

TSH: 0.761

FT4: 1.37 (0.76-1.41)

FT3: 2.11 (2.18-4)

TSH: 0.844

Updated today. New labs:

FT4: 1.41 (0.76-1.46)

FT3: 2.29 (2.18-4)

TSH: 0.841 (0.358-3.74)

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Meanbeannyc
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78 Replies

Why do I feel so bad with these levels?

Because your FT3 is barely scraping into range.

Looks like you could use some additional T3

Meanbeannyc profile image
Meanbeannyc in reply to

Isn’t my FT4 also low?

radd profile image
radd

Mb,

I agree with Witchinghour in that you need to raise those FT3 levels. However, it is not only about good thyroid hormones labs as you have previously found out.

Reasons why you may find raising T3 difficult;

Low iron levels - A very common reason & also one that can cause the breathlessness & air hunger that increases the higher you try to raise T3 levels. Your ferritin was low but you previously indicated adequate serum iron. You do not need high ferritin levels to raise T3 (ferritin is not iron but a storage protein) but if you don't, it is absolutely essential to have adequate serum iron levels. You recently indicated to SlowDragon you were having a complete iron panel. Can you post these results?

Adrenal issues - We briefly discussed your low DHEA levels which are being addressed with your naturopath. Think of how much T3 speeds up the metabolism and if adrenals are flagging they simply can not immediately keep up. This has caused me feelings of vertigo & derealisation as well as the breathlessness seen with the low iron levels above. You may find 6 months with adrenal supports allows a better T3 introduction. Medicating T3 can actually raise blood sugars significantly but balanced cortisol/DHEA will encourage good blood glucose levels which are required for T3 uptake into the cells to do its thing.

Sex hormones - I previously mentioned raised testosterone but you indicated it wasn’t possible because you are small in stature. If you are peri-menopausal, then possible raised oestrogen will encourage more binding carriers that risk binding thyroid hormone. If you are menopausal, poor adrenal reserve might mean a deficiency in both O & P & elevated testosterone such as I had myself & I am quite small in stature also. Any sex hormone imbalance will prevent thyroid hormones from working effectively on some level.

I am not sure if low VitD would have a direct impact on T3 being tolerated but it will inhibit other good actions. Yours was previously low. Is this being addressed?

Protein - It is great you previously said you eat clean, and lots of protein. I don’t particularly like meat but eat a little because have noticed the significant differences protein makes to how my thyroid meds work & in particular T3. I also use pea protein in smoothies.

I also think you need to slow down in your pursuit of well-being because hormones can takes months & months to re-regulate themselves. All systems are connected and it may be that by addressing all of the above T4 conversion improves enough that you don’t even need to medicate T3. I have a small DIO2 impairment myself and so need to medicate a tiny bit of T3 but concentrate on getting the rest by good T4 conversion as believe the conversion process contributes a lot to longer term homeostasis.

Meanbeannyc profile image
Meanbeannyc in reply toradd

Naturopath checked my sex hormones, LH, estrogen, etc. all looked normal.

Correct, Ferritin low but iron normal. Not being addressed.

Vitamin D is being addressed with low IU D3/K2 oral solution daily. Will have labs soon to see if it has made a difference.

Slow down? I’ve been on the same dose for almost a year. Idk how much slower I can go. lol

radd profile image
radd in reply toMeanbeannyc

Mb,

An iron panel can be tricky to read. How high was serum iron in range & was TIBG corresponding? These levels are important because you don’t have adequate ferritin.

These results can also indicate the necessity for further investigation into possible conditions like anaemia or early onset RBC issues. Both a possibility given your poor ferritin & Vit D levels indicating poor gut absorption on some level. Roughly 20% of thyroid hormone will be converted in the gut if conditions are healthy.

Being on the same thyroid hormone dose for a year means nothing if you aren’t addressing the barriers that are preventing it from working well. ‘Slowing down’ related to keeping your focus on the required cofactors for encouraging your body to accept additional thyroid hormone and being able to utilise it well. The longer we remain under-medicated the further factors will need eliminating from enquiry in both number & depth.

Otherwise I guess it’s waiting until adrenal issues are more balanced. Hope your naturist is helpful 😊

Meanbeannyc profile image
Meanbeannyc in reply toradd

Well maybe I should switch to a liquid levo like tirosint or tiro sol if I’m having an absorption issue… but FT4 goes up with increases. So I don’t think absorption is an issue.

Vitamin D is being addressed with D3/K2.

Haven’t had an iron and TIBC in a while. But had a ferritin 2 weeks ago. Results as follows:

36 (8-252)

radd profile image
radd in reply toMeanbeannyc

Mb,

I don't think you should change anything until iron panel is done because adequate thyroid hormone will improve absorption of everything.

Knowing timings of TFT's & assuming they were done like for like means they can be worked with.

Meanbeannyc profile image
Meanbeannyc in reply toradd

Vitamin D back into range with the D3/K2 substitution!

D: 30 (20-50)

Meanbeannyc profile image
Meanbeannyc in reply toradd

They did not do full iron panel. I will ask at next blood draw. Just ferritin was done.

SlowDragon profile image
SlowDragonAdministrator

Important to regularly retest vitamin D, folate, ferritin and B12 as well

What vitamin supplements are you currently taking

Low Ft3 and low vitamin levels often linked

Ft3 is far too low

For good conversion of Ft4 to ft3 we need optimal vitamin levels

Are you on strictly gluten free diet

Meanbeannyc profile image
Meanbeannyc in reply toSlowDragon

Haven’t had new vitamins yet. Just taking the D3/K2. Not gluten free no.

greygoose profile image
greygoose

So, you're still taking 112 mcg levo. No T3 now? You were taking 5 mcg T3 - or 7.5 mcg, it was never very clear.

What time of day were all these labs done? Were they all done at the same time of day? If not, you can't compare them.

How long was the gap between your last dose of levo and the blood draw? And the last dose of T3 and the blood draw when taken?

All these details are essentail for anybody to be able to interpret your blood test results.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

112 for the first labs, then the bottom 2 are 112/5.

All done at 12-2pm fasting. All meds taken 24 hours before.

SlowDragon profile image
SlowDragonAdministrator in reply toMeanbeannyc

What was reason for thyroidectomy?

Please add most recent vitamin D, folate, ferritin and B12 results and ranges

Meanbeannyc profile image
Meanbeannyc in reply toSlowDragon

Only have had Vit D, Ferr, B12 last month.. (9/14/21 labs were drawn)

Vitamin D: 21 (20-50) started supplementing D3/K2.

B12: 555 (211-911)

Ferritin: 46 (8-252)

Thyroidectomy due to Graves’ disease

SlowDragon profile image
SlowDragonAdministrator in reply toMeanbeannyc

So vitamin D is far too low…looking at improving to 40ng/ml (that’s around 100nmol in U.K. units)

But had a ferritin 2 weeks ago. Results as follows:

36 (8-252)

Ferritin also low.look at increasing iron rich foods in diet. Looking for ferritin to improve to at least around 70.

Meanwhile getting full iron panel test for anaemia. Never take iron supplements unless full iron panel test shows low iron. It’s possible to have low ferritin and high iron

Low vitamin levels suggests your under medicated for thyroid

Being under medicated for thyroid results in low stomach acid and poor nutrient absorption and low vitamin levels as direct result

Low vitamin levels leads to poor conversion of Ft4 to Ft3

Taking a daily vitamin B complex will help maintain optimal B vitamins including folate and B12

Remember to stop taking vitamin B complex a week before all blood tests as contains biotin and biotin can falsely affect test results

Suggest you work on improving low vitamin levels for 6 weeks

Then retest thyroid correctly

Testing as early as possible in morning before eating or drinking anything other than water. Last dose levothyroxine 24 hours before test

Are you currently taking taking T3

Day before test split T3 into 2 or 3 doses roughly equal 8 hour intervals. Last 1/3rd of daily dose T3 approx 8-12 hours before test

Typically when taking T3 alongside levothyroxine, dose is 2 x 5mcg or 3 x 5mcg per day

Meanbeannyc profile image
Meanbeannyc in reply toSlowDragon

I have been on the vitamin D for a while. I will have labs soon.

SlowDragon profile image
SlowDragonAdministrator in reply toMeanbeannyc

As you have/had Graves’ disease it’s ALWAYS worth trying absolutely strictly gluten free diet

Get coeliac blood test done BEFORE cutting gluten out

If you test positive for coeliac, will need to remain on gluten rich diet until endoscopy

If result is negative can consider trialing strictly gluten free diet for 3-6 months. Likely to see benefits. Can take many months for brain fog to lift.

If no obvious improvement, reintroduce gluten see if symptoms get worse.

chriskresser.com/the-gluten...

amymyersmd.com/2018/04/3-re...

Meanbeannyc profile image
Meanbeannyc in reply toSlowDragon

I just looked up high gluten foods. I don’t think I eat very much gluten daily. eggs, Turkey, chicken, oatmeal, fruit, yogurt. That’s my usual daily intake. Then 2 days a week pizza, fast food, candy, etc.

SlowDragon profile image
SlowDragonAdministrator in reply toMeanbeannyc

So it takes 2-4 months for gut to recover each time you eat gluten

It needs to be absolutely strictly gluten free to be effective

Meanbeannyc profile image
Meanbeannyc in reply toSlowDragon

I’ve been taking vitamin D for months and it has dipped lower. Who knows

SlowDragon profile image
SlowDragonAdministrator in reply toMeanbeannyc

How much vitamin D were you taking

With thyroid disease we frequently need higher dose than typical

Test twice year

Meanbeannyc profile image
Meanbeannyc in reply toSlowDragon

1200 D3/k2 it’s the only amount I could stomach without nausea

SlowDragon profile image
SlowDragonAdministrator in reply toMeanbeannyc

Try vitamin D mouth spray eg Better You vitamin D mouth spray available as 1000iu or 3000iu dose per spray

Suggest you get 1000iu and try 2 or 3 sprays per day

Any vitamin D tablets you swallow must be minimum 4 hours away from levothyroxine and taken with food

greygoose profile image
greygoose in reply toMeanbeannyc

OK, so you have a false low FT3, there. And your TSH isn't as high as it would be if you'd had the blood draw before 9 am. So, frankly, those labs don't tell us very much.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

But isn’t my circadian rhythm different due to my time schedule goose? My 9am is noon.

greygoose profile image
greygoose in reply toMeanbeannyc

No, as I've told you before, it doesn't work like that. But, even if it did, and 9 am was your noon, you're still having the blood draw too late in the day. You're not having it when the TSH is at its highest. You'd have to have the blood draw around 6 in the morning.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Well goosie. They have agreed to up my dose. Whether it’s T4 or T3 is up to me. 125mcg levo being filled now.

greygoose profile image
greygoose in reply toMeanbeannyc

Lord your doctors are useless! It's T3 you need.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

My tsh is slowly going up every week. Now back to 2.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Yes yes they are

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

I saw a different doctor and he’s sending me for a bunch of tests, he REALLY wants me to switch to armour after preparing my body for the higher T3 levels. We’ll see what he says when he gets my results.

greygoose profile image
greygoose in reply toMeanbeannyc

Well, that sounds promising. Do you want ot switch to Armour?

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

At this point, I’ll put anything in my mouth.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

What do I do now that my tsh is 2 goosie? :(

greygoose profile image
greygoose in reply toMeanbeannyc

Increase your T3 - as I've been telling you for years.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

To how much?! Winter is coming

greygoose profile image
greygoose in reply toMeanbeannyc

Winter has nothing to do with it. You should not raise your dose of T3 by more than 5 mcg at a time whatever the season.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

I think I need more TRH in the winter. And less in the summer. Idk.

greygoose profile image
greygoose in reply toMeanbeannyc

That's very possibly so. But, you still can't increase your T3 by more than 5 mcg at a time. You have to work up slowly.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Understood.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Naturopath will not increase T4, only T3.. that’s where I’m at currently. Last tsh was 2.

greygoose profile image
greygoose in reply toMeanbeannyc

I can understand why. So, when are you going to stop talking about increasing your T3 and actually doing it? :) You posted this question 20 days ago and you still haven't done anything about it.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Yes she basically said eat that shit til I explode and then pull back. New labs posted below.

greygoose profile image
greygoose in reply toMeanbeannyc

That's one way of looking at it.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

It’s the weather messing with my dosing for sure.

greygoose profile image
greygoose in reply toMeanbeannyc

I sincerely doubt it. Your FT3 has been much too low ever since I've known you, and you have always blamed it on the weather!

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

How come I can’t go into the cold supermarket? :(

greygoose profile image
greygoose in reply toMeanbeannyc

Because you're hypo and your thermostat is broken.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

But I feel really bad in the cold and really good in the heat.

greygoose profile image
greygoose in reply toMeanbeannyc

So do a lot of other hypos. Which just means that in the cold, you need more T3 because your FT3 is too low. That does not mean that 'the weather is messing with your dose'. It just means that you don't have sufficient T3 in your system to heat your body when the weather turns cold.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

So how do you ever get leveled if you need more in winter etc

greygoose profile image
greygoose in reply toMeanbeannyc

Well, thousands of other hypos manage it! But, first, you have to optimise your dose in winter, and you are a long way off doing that. You need to increase your T3 by 5 mcg.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

No more T4?

greygoose profile image
greygoose in reply toMeanbeannyc

Increasing your T4 - as I've explained many times - will take your FT4 over-range but won't do much to raise your FT3. T4 is the storage hormone, T3 is the active hormone, so it's T3 that you need to raise.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

did u see new labs?

greygoose profile image
greygoose in reply toMeanbeannyc

Yes. That's what I based my last reply on.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Thank you for your time and response goosie ! ❤️

greygoose profile image
greygoose in reply toMeanbeannyc

You're welcome.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Well in other good news, my vitamin D is in normal range! :) D3/K2 worked!

Vitamin D: 30 (20-50)

greygoose profile image
greygoose in reply toMeanbeannyc

Still a bit on the low side. Have you been taking at least 350 mg magnesium with it?

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Idk if it’s 350, but it’s Mg tissue salts from the naturopath.

Still goosie! It was 19 2 months ago :)

Mg: 2 (1.4-2.2) :)

greygoose profile image
greygoose in reply toMeanbeannyc

As I've said before, no point in testing magnesium. The results might look good but you could still be deficient. And, taking vit D uses up your magnesium, so you always need to take them together.

I've no idea what Mg tissue salts are. Sounds weird to me.

Yes, vit D has improved, but could still be higher, so don't stop supplementing yet.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

The tissue salts have been awesome! Not stopping the D, feel good on the D. :)

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Endo who wants me on armour wants me to start at 30mg, IM NOT DOING THAT!

greygoose profile image
greygoose in reply toMeanbeannyc

No, that would be a reduction in dose. You would need to start on at least 1 grain - 60 mg.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Well I’m not starting on 30. Either way, I’m not seeing him again.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

I think he had a complex. I’m not trying to deal with that.

Meanbeannyc profile image
Meanbeannyc in reply togreygoose

Update: NEW LABS:

FT4: 1.41 (0.76-1.46)

FT3: 2.29 (2.18-4)

TSH: 0.841 (0.358-3.74)

radd profile image
radd

Mb,

Have you had your full iron panel yet?

Meanbeannyc profile image
Meanbeannyc in reply toradd

I did! Today! Hold on!

Meanbeannyc profile image
Meanbeannyc in reply toradd

Iron: 97 (40-150)

TIBC: 375 (250-450)

Iron sat: 26 (11-46)

Ferr: 28 (8-252)

radd profile image
radd in reply toMeanbeannyc

Mb,

Iron: 97 (40-150)

TIBC: 375 (250-450)

Iron sat: 26 (11-46)

Ferr: 28 (8-252)

Insufficient levels of iron/ferritin is very common on the forum. Having an iron panel offers info on how iron mechanisms are working as well as the amounts. Sometimes the more thyroid hormone levels are tried to be optimised, the more the manifestations of iron deficiency are exposed because thyroid hormones increase the rate of RBC formation (erythropoiesis) and iron requirements increase.

Your serum iron is half way through range. TIBC should correlate but is slightly higher. AS TIBC shows the amount of transferrin proteins available for binding iron, higher amounts than serum iron levels is a good indicator of (early onset) iron deficiency, ie your body is trying to carry more iron for utilising by the liver creating more transporters, but insufficient iron amounts mean these transporters remain unbound.

A calculation of these two results shows iron saturation at 26% is low. The ideal is anywhere between 35 - 45%. And lastly your ferritin is just 8.20 % through range.

Because your results are a little ambiguous you need to combine them with a recent blood count. If results showed healthy RBC's (shape, size, number) and adequate haemoglobin levels, iron mechanisms are working ok and you could probably raise levels by eating iron rich foods and being mindful of what encourages/discourages good absorption. Also, if you have gut issues & low stomach acid supplementing Betaine helps enormously with absorption.

However, if results showed low haemoglobin levels and/or struggling RBC’s, you are heading towards full blown anaemia. Supplementing a low dose of iron will raise levels quicker but would need to be retested after several weeks, and ferritin may not raise for a while until thyroid hormones are optimised and other iron mechanisms are more normalised.

Meanbeannyc profile image
Meanbeannyc in reply toradd

I had a bunch of labs done today. I do have a CBCD with H&H and RBC. No indication of any abnormal RBC morphology. I can post those results along with thyroid panel as well from today.

Meanbeannyc profile image
Meanbeannyc in reply toradd

RBC: 4.26 (4-6)

Hgb: 13.5 (11.7-15.5)

Hct: 40.30 (35-45)

MCV: 94.6 (80-100)

MCH: 31.7 (27-33)

MCHC: 33.5 (31-36)

RDW: 12.9 (11-15)

radd profile image
radd in reply toMeanbeannyc

Mb,

I agree these results are thankfully looking good.

Meanbeannyc profile image
Meanbeannyc in reply toradd

Great to hear! :)

radd profile image
radd in reply toMeanbeannyc

Mb,

What are you going to do about optimising iron levels?

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