B12 to UK

[conrad0602]

Wondering where are the best places to order hydroxocobolamin amps to the UK post brexit for a decent price? Tried a couple of the German sites recommend on previous posts but they have declined UK address... Any help would be much appreciated. Thank you

[humanbean]

The best place to ask would be the Pernicious Anaemia Society Forum here on HealthUnlocked. You can find them here :

healthunlocked.com/pasoc

[Polaris]

I believe these two German pharmacies are still sending to the UK 🤞

bodfeld-apotheke.de/product...

apohealth.de/en/products/b1...

[Polaris in reply to Polaris]

PS. I'm not sure yet so wouldn't recommend instead of injections, but I've been supplementing injections with small daily doses of the new liposomal hydroxocobalamin B12 drops and have had more energy than in years 🤗

Very simply put, the B12 is in a bubble of oil, which carries it to the cells.

[conrad0602 in reply to Polaris]

Good to know, I haven't tried liposomal before. Perhaps it's the way to go with the restrictions getting injectable into UK . Will look into it. cheers

[Polaris in reply to conrad0602]

I agree. It's probably a more expensive way of getting B12 than injections and I'm not sure how much is absorbed but it would take the worry out of wondering how long German pharmacies will carry on supplying it.

[helvella Administrator Thyroid UK in reply to Polaris]

Have any papers been published on liposomal B12?

I couldn't find any.

[Polaris in reply to helvella]

This is all I found:

oatext.com/evaluation-of-li...

I originally heard about liposomal B12 recently in a very interesting video interview with researcher, Dr Carmen Wheatley, who called it 'a pan vitamin'.

[Polaris in reply to helvella]

Just noticed 'B12injustice' on the PA forum needs to get levels up quickly before an operation very soon and asked about injections.....

I'm unable to reply but Lipolife liposomal might help until able to inject ?

[tomoola in reply to helvella]

oatext.com/evaluation-of-li... Here is a report of a trial using 1000 micrograms using liposomal methylcobalamin, not hydroxocobalamin. The trial appeared to be quite successful.

[helvella Administrator Thyroid UK in reply to tomoola]

Unfortunately, I don't think that study shows a lot. Small number. Not compared with conventional B12 tablets (whether dissolved in mouth or swallowed).

It just shows that the form used does seem, somehow, to get absorbed in people without severe absorption issues. Which, to be fair, seems to be all they were expecting to achieve.

[tomoola in reply to helvella]

The points you make re the study are relevant. Liposomal delivery is of course, meant to bypass some of the usual absorption bottlenecks and speaking as a diagnosed coeliac, I can report some success with both iron and magnesium supplementation as liposomes. If there are real problems in obtaining sufficient injectable B12 , then a liposomal version might be a useful back up or even a possible replacement for some.

[Polaris]

Thank you Scrumbler. This is the one I'm using : also available from Amazon:

bodykind.com/product/12701-...

[helvella Administrator Thyroid UK]

From the link you included:

For vitamin B12 to be absorbed effectively, the stomach secretes a special protein carrier known as the intrinsic factor.

Liposomal B12 has an oily layer surrounding the B12.

This is heralded as enabling absorption of the B12 directly through the gut wall and thence through the cell walls - as a tiny droplet.

But if the B12 is surrounded by an oily layer, how can Intrinsic Factor attach to the B12?

If Intrinsic Factor can't do that, well, I can't see it has any role with respect to liposomal B12.

And if it has no role, what does that statement mean?

It appears to be a part of the standard description of B12 absorption included without making sense in the context. Or there is something misleading about the description as to how liposomal B12 is absorbed.

[helvella Administrator Thyroid UK]

So why mention Intrinsic Factor at all (other than saying something like "Liposomal B12 avoids IF issues"?

IF simply cannot work on liposomal B12.

In that link, it also says:

Liposomes penetrate the blood-brain barrier, an obstacle for other formulations

Which could be a concern. The blood-brain barrier serves a purpose and taking things that can whizz straight through might not always be desirable.

[helvella Administrator Thyroid UK]

Quite - and, yes, far too much is shrouded in uncertain language.

Whilst we are pretty content with high blood B12, what is the impact of high B12 in the brain?

[helvella Administrator Thyroid UK]

Very interesting. And I am impressed by the careful language employed and warnings to be thoughtful about any inferences and not to make any assumptions.

When we look at autism, we very much need to consider whether the mothers had high or low B12, and whether they took supplementary B12. Even if just to eliminate these factors!

[helvella Administrator Thyroid UK]

Have hopped over to PAS and posted:

healthunlocked.com/pasoc/po...

[Polaris in reply to helvella]

Yes, I notice you posted on the PA forum helvella and and a member made rather unnecessarily rude remarks calling the manufacturers "stupid"....

I first heard about the hope for a liposomal form of B12 spoken about by a well known and respected doctor and researcher at a PA conference some years ago.

I'm now wondering just why unfounded derogatory remarks are taken seriously 🤔 as it obviously works really well for some, if not others. We're all different so why not let those who want to try it find out for themselves whether it works or not?