My new results are here ... : ...... Results from... - Thyroid UK

Thyroid UK

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My new results are here ...

Adam40 profile image
7 Replies

...... Results from 9-3-21

Pathology Investigations

Thyroid function test

Serum TSH level 22.3 mu/L [0.35 - 5.5]

Above high reference limit

Serum free T4 level 12 pmol/L [9.0 - 23.0]

Comment: Query clinical evidence of under replacement

Here’s my previous ..... from 11-1-21

Pathology Investigations

Thyroid function test

Serum TSH level 13.1 mu/L [0.35 - 5.5]

Above high reference limit

Serum free T4 level 12 pmol/L [9.0 - 23.0]

Comment: TSH>10 usually indicates primary hypothyroidism

Shouldn’t my levels be going down now I’m on a higher dose ?

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Adam40
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7 Replies
SlowDragon profile image
SlowDragonAdministrator

Reading through previous posts

Your TSH was extremely high at diagnosis and Ft4 extremely low

Male and 6.1 and around 16st 5

You still have several dose increases still to go

Get next 25mcg dose increase in levothyroxine up to 125mcg

Looking at previous posts you are taking Accord levothyroxine. (Also boxed as Almus and Northstar)

Accord don’t make 25mcg tablets. Ask GP for prescription for 50mcg tablets and cut in half to get 25mcg

Thyroid levels should be retested 6-8 weeks after EACH dose increase

guidelines on dose levothyroxine by weight

16 stone 5 pounds = 103.8 kilo

104 x 1.6= 166mcg levothyroxine as the likely daily dose required

Even if we frequently don’t start on full replacement dose, most people need to increase levothyroxine dose slowly upwards in 25mcg steps (retesting 6-8 weeks after each increase) until eventually on, or near full replacement dose

NICE guidelines on full replacement dose

nice.org.uk/guidance/ng145/...

1.3.6

Consider starting levothyroxine at a dosage of 1.6 micrograms per kilogram of body weight per day (rounded to the nearest 25 micrograms) for adults under 65 with primary hypothyroidism and no history of cardiovascular disease.

Also here

cks.nice.org.uk/topics/hypo...

gp-update.co.uk/Latest-Upda...

Traditionally we have tended to start patients on a low dose of levothyroxine and titrate it up over a period of months. RCT evidence suggests that for the majority of patients this is not necessary and may waste resources.

For patients aged >60y or with ischaemic heart disease, start levothyroxine at 25–50μg daily and titrate up every 3 to 6 weeks as tolerated.

For ALL other patients start at full replacement dose. For most this will equate to 1.6 μg/kg/day (approximately 100μg for a 60kg woman and 125μg for a 75kg man).

If you are starting treatment for subclinical hypothyroidism, this article advises starting at a dose close to the full treatment dose on the basis that it is difficult to assess symptom response unless a therapeutic dose has been trialled.

BMJ also clear on dose required

bmj.com/content/368/bmj.m41

bestpractice.bmj.com/topics...

SlowDragon profile image
SlowDragonAdministrator

Have you had vitamin D, folate, ferritin and B12 levels tested yet

Or thyroid antibodies and coeliac blood test?

Low vitamin levels are extremely common when hypothyroid and improving low vitamin levels helps how levothyroxine works and improving low vitamin levels can significantly improve symptoms

If GP unhelpful, test privately

Perhaps starting with vitamin D test

NHS easy postal kit vitamin D test £29 via

vitamindtest.org.uk

Adam40 profile image
Adam40 in reply to SlowDragon

GP is extremely unhelpful and uninterested in anything that’s not COVID related, I’m going to order a kit tomorrow

SlowDragon profile image
SlowDragonAdministrator in reply to Adam40

GP should have immediately increased dose levothyroxine to 125mcg daily after these results

Adam40 profile image
Adam40

My TSH was coming down nicely but seems to have spiked back up

SlowDragon profile image
SlowDragonAdministrator in reply to Adam40

Because you are ready for next dose increase

Contact GP for new prescription

Bloods should be retested 6-8 weeks time....and you will be ready for next increase by then

If not done so already, get a weekly pill dispenser so that it’s easy to see if you have forgotten daily tablets (and put the cut half tablet in next days slot)

Imaaan profile image
Imaaan

Hey

I've had my tsh shoot up whenever my ferratin goes down and improve when the ferratin increased. As slow dragon suggested try to get ferratin, b12, iron, vit d, folate tested.

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