T3 and talc: Hi, I've recently had an issue with... - Thyroid UK

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T3 and talc

jrbarnes profile image
36 Replies

Hi,

I've recently had an issue with a generic liothyronine here in the US, which is manufactured by a subsidiary of Pfizer. It felt like I was taking nothing. Today, I transferred the prescription to a different location to get another generic by Sigmapharm. I notice Sigmapharm does not put Talc in their pills. Has anyone had experience with Talc affecting the efficacy of liothyronine pills or is it simply down to poor manufacturing?

I knew something was off when I took 10 mcg of the liothyronine and felt no therapeutic benefit. The next day I took 1 grain of NDT, which has 9.5 mcg of liothyronine and felt positive improvements within the hour.

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jrbarnes profile image
jrbarnes
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helvella profile image
helvellaAdministrator

Greenstone?

dailymed.nlm.nih.gov/dailym...

I think you will find it is manufactured by Peptido GmbH - in Germany.

Inactive ingredients consist of calcium sulfate, corn starch, gelatin, stearic acid, sucrose and talc.

In the UK, I'd suggest reporting via the Yellow Card system. I think the nearest equivalent in the USA is this:

How Consumers Can Report an Adverse Event or Serious Problem to FDA

fda.gov/safety/reporting-se...

jrbarnes profile image
jrbarnes in reply tohelvella

Yes, it is distributed by Greenstone and embossed with KPI 115, for King pharmaceuticals. I reported it to the FDA as well as the pharmaceutical company.

NYArtist1 profile image
NYArtist1 in reply tohelvella

Some of those incredients like corn starch (GM)) are not what I would want to ingest. :(

helvella profile image
helvellaAdministrator in reply toNYArtist1

I think you just might be making an assumption about GM corn starch.

The product is manufactured in the EU where GM corn is not allowed in food.

I suspect it would not be allowed in medicines either.

sunsetssr profile image
sunsetssr

I take the liothyronine sodium tab which is the generic of Cytomel 5 Mcg and it is working for me. Wish you luck with your medication.

jrbarnes profile image
jrbarnes in reply tosunsetssr

Hi, does it have a letter or number on the pill ?

sunsetssr profile image
sunsetssr in reply tojrbarnes

No just the dose 5mcg.

helvella profile image
helvellaAdministrator in reply tosunsetssr

I'm not clear - are you saying that is Greenstone? Or another brand/make/product?

sunsetssr profile image
sunsetssr in reply tohelvella

I live in the State /in California and the brand I'm prescribed is liothyronine sodium tab which is the generic of Cytomel 5 Mcg.

helvella profile image
helvellaAdministrator in reply tosunsetssr

I am confused!

That isn't a brand. That is just the generic name.

Is it not in any packaging when you get it?

sunsetssr profile image
sunsetssr in reply tohelvella

Sorry, no package. I'm sorry I'm confusing you.

jrbarnes profile image
jrbarnes in reply tosunsetssr

There should be some numbers or letters printed on the pills. If you knew what they were then I could find out where it is manufactured.

sunsetssr profile image
sunsetssr in reply tojrbarnes

There is these #s on the pill.52020.Unfortunately I cannot give you more info. because the 90 days supplies I get are thru a plastic bottle.Good luck to you

jrbarnes profile image
jrbarnes in reply tosunsetssr

If it starts with a 5 then it sounds like it's supplied by Paddock.

helvella profile image
helvellaAdministrator in reply tojrbarnes

Paddock no longer produce liothyronine!

Paddock was taken over by Perrigo.

Perrigo was taken over by Mayne Pharma.

Mayne Pharma, for a short time, rebranded it as Libertas, but then reverted to Mayne Pharma - which I think it now is!

jrbarnes profile image
jrbarnes in reply tohelvella

My goodness, what a trail of breadcrumbs. I always check my bottle before I leave the pharmacy.

NYArtist1 profile image
NYArtist1 in reply tohelvella

Mayne has talc in it. I just spoke with them. But it doesn't have the sucrose or GMO corn starch.

NYArtist1 profile image
NYArtist1 in reply tojrbarnes

I believe that would be a 582

jrbarnes profile image
jrbarnes in reply tohelvella

In the UK are pills packaged in boxes and blister packs? In the US pills are dispensed into plastic bottles.

helvella profile image
helvellaAdministrator in reply tojrbarnes

Yes - but don't the plastic bottles have labels attached?

jrbarnes profile image
jrbarnes in reply tohelvella

Yes they do so that member should be able to look on the bottle and tell us....

sunsetssr profile image
sunsetssr in reply tojrbarnes

Finally able to find it. It is Mayne phar. is the manufacture co.

Batty1 profile image
Batty1 in reply tohelvella

Us bottles don’t have manufacture info on it, pharmacy should be able to tell people the manufacture if they ask.

helvella profile image
helvellaAdministrator in reply toBatty1

You don't need to ask a pharmacy. :-) Just go to this FDA site:

dailymed.nlm.nih.gov/dailymed/

All the labels I have seen say something about the manufacturing.

Mayne Pharma liothyronine:

dailymed.nlm.nih.gov/dailym...

NYArtist1 profile image
NYArtist1 in reply tosunsetssr

Does it have GMO corn starch, talc and sucrose in it?

chrysalis56 profile image
chrysalis56

Many thanks for posting about your experiences with King Pharmaceuticals liothyronine. As Cynomel (Sanofi-Aventis, France) is currently unavailable in Israel, I ordered from a US pharmacy, what I was told was Pfizer brand-name Cytomel. When I asked the pharmacy why it came from King Pharmaceuticals, I was told that King Pharmaceuticals was purchased by Pfizer; therefore, they are the same company. I have used this pharmacy in the past, and consider them reliable.

By the way, the embossing on my pills is KPI 116, very similar to yours. So even assuming that I was sent Cytomel, and not a generic, there may be a problem with the King Pharmaceuticals version. I have not yet tried my tablets, as I still have a little of the Sanofi-Aventis Cynomel in stock.

Has anyone else had experience with King Pharmaceuticals Cytomel, or the generic version?

Wishing you all the best of good health,

Chrysalis56

jrbarnes profile image
jrbarnes in reply tochrysalis56

It is confusing when a large company purchases another. I was paying for a generic but had I requested the name brand Cytomel it would have come from the same place with the same embossing, only I would have payed more. KPI 116 is the 25 mcg and KPI 115 is the 5 mcg.

I have not read of any problems with Cytomel so I may be sensitive. Please let us know if you experience any bad side effects.

Best wishes and good health to you

helvella profile image
helvellaAdministrator in reply tochrysalis56

Pfizer bought King many years ago. They have simply chosen not to change the markings on the tablets.

There are many tablets which have the markings they have for historic reasons. That is, it made sense when defined but not all these years later.

chrysalis56 profile image
chrysalis56 in reply tohelvella

Dear Helvella and jrbarnes,

Thank you both for taking a moment to respond.

Unless I am mistaken, what jrbarnes seems to be telling me is that I paid (alot?) more money by requesting Pfizer brand-name Cytomel, now manufactured by King Pharmaceuticals, for the exact same product that I would have been sent had I requested the generic liothyronine, and for (alot?) less money.

The only reason I didn't request a generic in the first place was because at first, I had wanted to try a product that most closely resembled Cynomel (Sanofi-Aventis, France), which I have been split-dosing and taking for years, and to which I have adjusted reasonably well.

jrbarnes, if you end up ordering generic liothyronine from Sigmapharm, please let me know if you respond positively to this brand.

My best, chrysalis56

NYArtist1 profile image
NYArtist1 in reply tochrysalis56

Still has the same ingredients that I want to avoid.

chrysalis56 profile image
chrysalis56

Dear Helvella and jrbarnes,

Thank you both for taking a moment to respond.

Unless I am mistaken, what jrbarnes seems to be telling me is that I paid (alot?) more money by requesting Pfizer brand-name Cytomel, now manufactured by King Pharmaceuticals, for the exact same product that I would have been sent had I requested the generic liothyronine, and for (alot?) less money.

The only reason I didn't request a generic in the first place was because at first, I had wanted to try a product that most closely resembled Cynomel (Sanofi-Aventis, France), which I have been split-dosing and taking for years, and to which I have adjusted reasonably well.

jrbarnes, if you end up ordering generic liothyronine from Sigmapharm, please let me know if you respond positively to this brand.

My best, chrysalis56

jrbarnes profile image
jrbarnes in reply tochrysalis56

Hi, I've been using Sigmapharm liothyronine successfully without any negative side effects.

chrysalis56 profile image
chrysalis56

Dear jrbarnes,

I so appreciate your response. I'm still using up my Cynomel (Sanofi-Aventis), will then try the Pfizer/King Pharmaceuticals Cytomel, and will order the Sigmapharm generic the next time I need to replenish my liothyronine supply.

Thanks again, and all best wishes,

chrysalis56

helvella profile image
helvellaAdministrator in reply tochrysalis56

I often suggest people try a new or different medicine while they still have some of their existing medicine available. The simple reason being that if it goes wrong at all, you have the option of reverting - at least for a while.

chrysalis56 profile image
chrysalis56 in reply tohelvella

Dear Helvella,

Thank you. Your point is very well taken, and I will try the new brand of liothyronine (Pfizer/King Pharmaceuticals brand name Cytomel). I may have to change the timing of my split-dosing, though, depending on how hard it is to split the pill into quarters. The 25 mcg Cytomel tablet that I just now received is only scored to be split into halves.

The only reason that I would hesitate at all is that healthwise, I'm trying very hard not to rock the boat.

Thanks again, my best,

chrysalis56

helvella profile image
helvellaAdministrator in reply tochrysalis56

Pleased you took it as a gentle suggestion! :-)

Best of luck whatever you do.

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